Lossy Mode Resonance Based Fiber Optic Creatinine Sensor Fabricated Using Molecular Imprinting Over Nanocomposite of MoS2/SnO2
Creatinine (CR) produced through the muscle metabolism acts as biomarker to monitor the kidney functioning of the human body. In this study, a successful effort has been made to develop a fast and easy detection method for the monitoring of CR concentration in an aqueous solution as well as in the a...
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| Veröffentlicht in: | IEEE sensors journal 2020-04, Vol.20 (8), p.4251-4259 |
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| creator | Sharma, Sonika Shrivastav, Anand M. Gupta, Banshi D. |
| description | Creatinine (CR) produced through the muscle metabolism acts as biomarker to monitor the kidney functioning of the human body. In this study, a successful effort has been made to develop a fast and easy detection method for the monitoring of CR concentration in an aqueous solution as well as in the artificial urine sample. The sensor has been developed over a lossy mode resonance (LMR) based optical fiber platform using MoS 2 @SnO 2 nanocomposite as LMR supporting material and MoS 2 @SnO 2 nanocomposite along with CR imprinted polymer film as artificial antibodies. The sensor's performance has been studied for the CR concentration range from 0 to 2000 μg/mL which lies within the physiological range found in human blood and urine. The maximum sensitivity and detection limit of the sensor have been found to be 0.41 nm/(μg/mL) and 1.86 μg/mL, respectively. The sensor has several advantages such as high selectivity, long-term stability, repeatability and fast response. The recovery of the sensor probes close to 100% with the artificial urine sample shows its potential use in the biomedical application. |
| doi_str_mv | 10.1109/JSEN.2020.2964262 |
| format | Article |
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In this study, a successful effort has been made to develop a fast and easy detection method for the monitoring of CR concentration in an aqueous solution as well as in the artificial urine sample. The sensor has been developed over a lossy mode resonance (LMR) based optical fiber platform using MoS 2 @SnO 2 nanocomposite as LMR supporting material and MoS 2 @SnO 2 nanocomposite along with CR imprinted polymer film as artificial antibodies. The sensor's performance has been studied for the CR concentration range from 0 to 2000 μg/mL which lies within the physiological range found in human blood and urine. The maximum sensitivity and detection limit of the sensor have been found to be 0.41 nm/(μg/mL) and 1.86 μg/mL, respectively. The sensor has several advantages such as high selectivity, long-term stability, repeatability and fast response. The recovery of the sensor probes close to 100% with the artificial urine sample shows its potential use in the biomedical application.</description><identifier>ISSN: 1530-437X</identifier><identifier>EISSN: 1558-1748</identifier><identifier>DOI: 10.1109/JSEN.2020.2964262</identifier><identifier>CODEN: ISJEAZ</identifier><language>eng</language><publisher>New York: IEEE</publisher><subject>Antibodies ; Aqueous solutions ; Biomarkers ; Biomedical materials ; Creatinine ; Fiber optics ; Imprinted polymers ; lossy mode resonance ; Molecular imprinting ; Molybdenum disulfide ; molybdenum sulphide ; Muscles ; Nanocomposites ; Optical device fabrication ; optical fiber sensor ; Optical fiber sensors ; Optical fibers ; Optical losses ; Polymer films ; Polymers ; Probes ; Resonance ; Selectivity ; Sensors ; Tin dioxide ; tin oxide ; Urine</subject><ispartof>IEEE sensors journal, 2020-04, Vol.20 (8), p.4251-4259</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-6505-7743</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/8950385$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,780,784,796,27923,27924,54757</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/8950385$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Sharma, Sonika</creatorcontrib><creatorcontrib>Shrivastav, Anand M.</creatorcontrib><creatorcontrib>Gupta, Banshi D.</creatorcontrib><title>Lossy Mode Resonance Based Fiber Optic Creatinine Sensor Fabricated Using Molecular Imprinting Over Nanocomposite of MoS2/SnO2</title><title>IEEE sensors journal</title><addtitle>JSEN</addtitle><description>Creatinine (CR) produced through the muscle metabolism acts as biomarker to monitor the kidney functioning of the human body. In this study, a successful effort has been made to develop a fast and easy detection method for the monitoring of CR concentration in an aqueous solution as well as in the artificial urine sample. The sensor has been developed over a lossy mode resonance (LMR) based optical fiber platform using MoS 2 @SnO 2 nanocomposite as LMR supporting material and MoS 2 @SnO 2 nanocomposite along with CR imprinted polymer film as artificial antibodies. The sensor's performance has been studied for the CR concentration range from 0 to 2000 μg/mL which lies within the physiological range found in human blood and urine. The maximum sensitivity and detection limit of the sensor have been found to be 0.41 nm/(μg/mL) and 1.86 μg/mL, respectively. The sensor has several advantages such as high selectivity, long-term stability, repeatability and fast response. The recovery of the sensor probes close to 100% with the artificial urine sample shows its potential use in the biomedical application.</description><subject>Antibodies</subject><subject>Aqueous solutions</subject><subject>Biomarkers</subject><subject>Biomedical materials</subject><subject>Creatinine</subject><subject>Fiber optics</subject><subject>Imprinted polymers</subject><subject>lossy mode resonance</subject><subject>Molecular imprinting</subject><subject>Molybdenum disulfide</subject><subject>molybdenum sulphide</subject><subject>Muscles</subject><subject>Nanocomposites</subject><subject>Optical device fabrication</subject><subject>optical fiber sensor</subject><subject>Optical fiber sensors</subject><subject>Optical fibers</subject><subject>Optical losses</subject><subject>Polymer films</subject><subject>Polymers</subject><subject>Probes</subject><subject>Resonance</subject><subject>Selectivity</subject><subject>Sensors</subject><subject>Tin dioxide</subject><subject>tin oxide</subject><subject>Urine</subject><issn>1530-437X</issn><issn>1558-1748</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNotj0tLw0AUhYMoWKs_QNwMuE47j8wjSy1WK7UBY8FdmExuZEo7E2dSoRt_uyl1dQ-Hj-9wk-SW4AkhOJ--lk-rCcUUT2guMiroWTIinKuUyEydHzPDacbk52VyFeMGY5JLLkfJ79LHeEBvvgH0DtE77QygRx2hQXNbQ0BF11uDZgF0b511gEpw0Qc013WwRvcDuI7WfQ2OLZj9Vge02HXBuv5YFj-DYqWdN37X-Wh7QL4d0JJOS1fQ6-Si1dsIN_93nKznTx-zl3RZPC9mD8vUUsz6tBWgONREZC0zucStlFgpziXkWGDCMeWUA-YC6kYZqhvNWs2UFI1i2JiajZP7k7cL_nsPsa82fh_cMFlRJnMmCM3EQN2dKAsA1fDDTodDpXKOmeLsD8Uiae0</recordid><startdate>20200415</startdate><enddate>20200415</enddate><creator>Sharma, Sonika</creator><creator>Shrivastav, Anand M.</creator><creator>Gupta, Banshi D.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0001-6505-7743</orcidid></search><sort><creationdate>20200415</creationdate><title>Lossy Mode Resonance Based Fiber Optic Creatinine Sensor Fabricated Using Molecular Imprinting Over Nanocomposite of MoS2/SnO2</title><author>Sharma, Sonika ; Shrivastav, Anand M. ; Gupta, Banshi D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i203t-f6e85eb164f3c970f77088557e90601502525e056ebd8c2ada3fa3876d830ccb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibodies</topic><topic>Aqueous solutions</topic><topic>Biomarkers</topic><topic>Biomedical materials</topic><topic>Creatinine</topic><topic>Fiber optics</topic><topic>Imprinted polymers</topic><topic>lossy mode resonance</topic><topic>Molecular imprinting</topic><topic>Molybdenum disulfide</topic><topic>molybdenum sulphide</topic><topic>Muscles</topic><topic>Nanocomposites</topic><topic>Optical device fabrication</topic><topic>optical fiber sensor</topic><topic>Optical fiber sensors</topic><topic>Optical fibers</topic><topic>Optical losses</topic><topic>Polymer films</topic><topic>Polymers</topic><topic>Probes</topic><topic>Resonance</topic><topic>Selectivity</topic><topic>Sensors</topic><topic>Tin dioxide</topic><topic>tin oxide</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Sonika</creatorcontrib><creatorcontrib>Shrivastav, Anand M.</creatorcontrib><creatorcontrib>Gupta, Banshi D.</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>IEEE sensors journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Sharma, Sonika</au><au>Shrivastav, Anand M.</au><au>Gupta, Banshi D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lossy Mode Resonance Based Fiber Optic Creatinine Sensor Fabricated Using Molecular Imprinting Over Nanocomposite of MoS2/SnO2</atitle><jtitle>IEEE sensors journal</jtitle><stitle>JSEN</stitle><date>2020-04-15</date><risdate>2020</risdate><volume>20</volume><issue>8</issue><spage>4251</spage><epage>4259</epage><pages>4251-4259</pages><issn>1530-437X</issn><eissn>1558-1748</eissn><coden>ISJEAZ</coden><abstract>Creatinine (CR) produced through the muscle metabolism acts as biomarker to monitor the kidney functioning of the human body. In this study, a successful effort has been made to develop a fast and easy detection method for the monitoring of CR concentration in an aqueous solution as well as in the artificial urine sample. The sensor has been developed over a lossy mode resonance (LMR) based optical fiber platform using MoS 2 @SnO 2 nanocomposite as LMR supporting material and MoS 2 @SnO 2 nanocomposite along with CR imprinted polymer film as artificial antibodies. The sensor's performance has been studied for the CR concentration range from 0 to 2000 μg/mL which lies within the physiological range found in human blood and urine. The maximum sensitivity and detection limit of the sensor have been found to be 0.41 nm/(μg/mL) and 1.86 μg/mL, respectively. The sensor has several advantages such as high selectivity, long-term stability, repeatability and fast response. The recovery of the sensor probes close to 100% with the artificial urine sample shows its potential use in the biomedical application.</abstract><cop>New York</cop><pub>IEEE</pub><doi>10.1109/JSEN.2020.2964262</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6505-7743</orcidid></addata></record> |
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| subjects | Antibodies Aqueous solutions Biomarkers Biomedical materials Creatinine Fiber optics Imprinted polymers lossy mode resonance Molecular imprinting Molybdenum disulfide molybdenum sulphide Muscles Nanocomposites Optical device fabrication optical fiber sensor Optical fiber sensors Optical fibers Optical losses Polymer films Polymers Probes Resonance Selectivity Sensors Tin dioxide tin oxide Urine |
| title | Lossy Mode Resonance Based Fiber Optic Creatinine Sensor Fabricated Using Molecular Imprinting Over Nanocomposite of MoS2/SnO2 |
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