Neuroplastic alterations accompanying long-term depression in the anesthetized rat hippocampus

Neuroplastic alterations accompanying long-term depression in the anesthetized rat hippocampus

The major goals of this study were to: (1) assess whether low-frequency stimulation (LFS) is effective at inducing long-term depression (LTD) of the perforant path/dentate gyrus synapse in the anesthetized adult rat hippocampus, and (2) determine the frequency at which the shift from LTD to LTP occu...

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Bibliographische Detailangaben
Hauptverfasser: Blaise, J.H., Bronzino, J.D.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Biomedical engineering
Biomedical measurements
Educational institutions
Electrodes
Frequency measurement
Hippocampus
Neuroplasticity
Pulse measurements
Rats
Signal analysis
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Zusammenfassung:The major goals of this study were to: (1) assess whether low-frequency stimulation (LFS) is effective at inducing long-term depression (LTD) of the perforant path/dentate gyrus synapse in the anesthetized adult rat hippocampus, and (2) determine the frequency at which the shift from LTD to LTP occurs. Measures of homosynaptic LTD were recorded in the dentate gyrus during experiments conducted on anesthetized adult rats, Our results indicate that stimulation frequencies lower than or equal to 7 Hz resulted in the induction of LTD of both PSA and EPSP slope measures, with a shift to LTP occurring approximately between 11 and 30 Hz stimulation.
DOI:10.1109/NEBC.2000.842398