Effects of Percutaneous Transluminal Angioplasty of Superficial Femoral Artery on Photoplethysmographic Pulse Transit Times

We analyze the changes in upper and lower limb pulse transit times (PTT) caused by peripheral artery disease (PAD) and its treatment with percutaneous transluminal angioplasty (PTA) of the superficial femoral artery. PTTs were extracted from the photoplethysmograms (PPG) recorded from an index finge...

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Veröffentlicht in:IEEE journal of biomedical and health informatics 2019-05, Vol.23 (3), p.1058-1065
Hauptverfasser: Peltokangas, Mikko, Suominen, Velipekka, Vakhitov, Damir, Korhonen, Janne, Verho, Jarmo, Mattila, Ville M., Romsi, Pekka, Lekkala, Jukka, Vehkaoja, Antti, Oksala, Niku
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container_title IEEE journal of biomedical and health informatics
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creator Peltokangas, Mikko
Suominen, Velipekka
Vakhitov, Damir
Korhonen, Janne
Verho, Jarmo
Mattila, Ville M.
Romsi, Pekka
Lekkala, Jukka
Vehkaoja, Antti
Oksala, Niku
description We analyze the changes in upper and lower limb pulse transit times (PTT) caused by peripheral artery disease (PAD) and its treatment with percutaneous transluminal angioplasty (PTA) of the superficial femoral artery. PTTs were extracted from the photoplethysmograms (PPG) recorded from an index finger and 2nd toes. PTTs were defined between the R-peaks of the ECG and different reference points of the PPG: foot and peak points, maxima of 1st and 2nd derivative, and by means of intersecting tangents method. Also the PTTs between the toe and finger pulses were analyzed. Our sample consists of 24 subjects examined before and after the PTA and in 1-month follow-up visit. Also 28 older than 65 years controls having normal ankle-to-brachial pressure index (ABI) and no history in cardiovascular diseases as well as 21 younger subjects were examined. The differences between the groups and pre- and post-treatment phases were analyzed by means of non-parametric statistical tests. The changes in the PTTs of upper limb and non-treated lower limb were negligible. The agreement with the reference values, ABI and toe pressures, was studied by kappa-analysis, resulting in kappa-values of 0.33-0.91. Differences in PTTs were found between pre-treatment state of the treated limb, post-treatment state and the follow-up visit, as well as between the pre-treatment state and controls. If patients' age and systolic blood pressure were taken into consideration, the method of lower limb PTT calculation from the peak point turns out feasible in finding the markers of PAD and monitoring post-treatment vascular remodellation.
doi_str_mv 10.1109/JBHI.2018.2851388
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Differences in PTTs were found between pre-treatment state of the treated limb, post-treatment state and the follow-up visit, as well as between the pre-treatment state and controls. 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PTTs were extracted from the photoplethysmograms (PPG) recorded from an index finger and 2nd toes. PTTs were defined between the R-peaks of the ECG and different reference points of the PPG: foot and peak points, maxima of 1st and 2nd derivative, and by means of intersecting tangents method. Also the PTTs between the toe and finger pulses were analyzed. Our sample consists of 24 subjects examined before and after the PTA and in 1-month follow-up visit. Also 28 older than 65 years controls having normal ankle-to-brachial pressure index (ABI) and no history in cardiovascular diseases as well as 21 younger subjects were examined. The differences between the groups and pre- and post-treatment phases were analyzed by means of non-parametric statistical tests. The changes in the PTTs of upper limb and non-treated lower limb were negligible. The agreement with the reference values, ABI and toe pressures, was studied by kappa-analysis, resulting in kappa-values of 0.33-0.91. 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identifier ISSN: 2168-2194
ispartof IEEE journal of biomedical and health informatics, 2019-05, Vol.23 (3), p.1058-1065
issn 2168-2194
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language eng
recordid cdi_ieee_primary_8399495
source IEEE Electronic Library (IEL)
subjects Adult
Aged
Angioplasty
Ankle
Arteries
Atherosclerosis
Blood pressure
Cardiovascular diseases
Electrocardiography
Female
Femoral artery
Femoral Artery - surgery
Femur
Fingers - blood supply
Fingers - physiology
Foot
Heart diseases
Hospitals
Humans
Indexes
Male
Medical treatment
Middle Aged
Peripheral Arterial Disease - surgery
Peripheral artery disease
Photoplethysmography
Photoplethysmography - methods
Photoplethysmography - statistics & numerical data
Pulse Wave Analysis - methods
Pulse Wave Analysis - statistics & numerical data
Pulse wave measurements
Signal Processing, Computer-Assisted
Statistical analysis
Statistical tests
Surgery
Tangents
Toes - blood supply
Toes - physiology
Transit time
Vascular diseases
title Effects of Percutaneous Transluminal Angioplasty of Superficial Femoral Artery on Photoplethysmographic Pulse Transit Times
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