Field Dependence Study of Commercial Gd Chelates With SQUID Detection
The contrast agents (CAs), which can enhance the image contrast by changing the relaxation times in the target locations, are widely used in clinical high-field magnetic resonance imaging (MRI). However, the commercial clinical CAs have attracted little attention in ultralow field (ULF) MRI, whose m...
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| Veröffentlicht in: | IEEE transactions on applied superconductivity 2016-08, Vol.26 (5), p.1-4 |
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| creator | Huang, Ruiqi Tao, Quan Chang, Baolin Dong, Hui |
| description | The contrast agents (CAs), which can enhance the image contrast by changing the relaxation times in the target locations, are widely used in clinical high-field magnetic resonance imaging (MRI). However, the commercial clinical CAs have attracted little attention in ultralow field (ULF) MRI, whose measurement field is four orders of magnitude lower than that of the clinical high-field counterpart. In this paper, we measure the relaxivity levels of three gadolinium (Gd)-based commercial CAs (Gd-DTPA, Gd-EOB-DTPA, and Gd-DTPA-BMA) with our four-channel magnetically unshielded ULF-MRI system using low-T c superconducting quantum interference devices as detectors. The system has a 0.65-T permanent-magnet pair as prepolarization field B p and applies a static B 0 field of 129 uT. We compare the longitudinal relaxivity levels of the CAs at B p and B 0 field strengths, as well as the reported values at 1.5 T. The results show that the relaxivity levels of three commercial CAs at 129 uT are all about twice those at high fields, which demonstrates one particular advantage of ULF-MRI. |
| doi_str_mv | 10.1109/TASC.2016.2555922 |
| format | Article |
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However, the commercial clinical CAs have attracted little attention in ultralow field (ULF) MRI, whose measurement field is four orders of magnitude lower than that of the clinical high-field counterpart. In this paper, we measure the relaxivity levels of three gadolinium (Gd)-based commercial CAs (Gd-DTPA, Gd-EOB-DTPA, and Gd-DTPA-BMA) with our four-channel magnetically unshielded ULF-MRI system using low-T c superconducting quantum interference devices as detectors. The system has a 0.65-T permanent-magnet pair as prepolarization field B p and applies a static B 0 field of 129 uT. We compare the longitudinal relaxivity levels of the CAs at B p and B 0 field strengths, as well as the reported values at 1.5 T. The results show that the relaxivity levels of three commercial CAs at 129 uT are all about twice those at high fields, which demonstrates one particular advantage of ULF-MRI.</description><identifier>ISSN: 1051-8223</identifier><identifier>EISSN: 1558-2515</identifier><identifier>DOI: 10.1109/TASC.2016.2555922</identifier><identifier>CODEN: ITASE9</identifier><language>eng</language><publisher>New York: IEEE</publisher><subject>Contrast agents ; Field strength ; Gadolinium ; Magnetic field measurement ; Magnetic fields ; Magnetic resonance imaging ; MRI contrast agent ; NMR ; Nuclear magnetic resonance ; Permanent magnets ; relaxivity ; SQUID ; SQUIDs ; Superconducting magnets ; Superconducting quantum interference devices ; Superconductivity ; Transportation ; ULF-MRI</subject><ispartof>IEEE transactions on applied superconductivity, 2016-08, Vol.26 (5), p.1-4</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-4c2a28ba70928951fa823f169a6e942ed9de04c4f87e5914a3d1cccde389b42e3</citedby><cites>FETCH-LOGICAL-c326t-4c2a28ba70928951fa823f169a6e942ed9de04c4f87e5914a3d1cccde389b42e3</cites><orcidid>0000-0002-6444-1134</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/7456208$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>315,781,785,797,27926,27927,54760</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/7456208$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Huang, Ruiqi</creatorcontrib><creatorcontrib>Tao, Quan</creatorcontrib><creatorcontrib>Chang, Baolin</creatorcontrib><creatorcontrib>Dong, Hui</creatorcontrib><title>Field Dependence Study of Commercial Gd Chelates With SQUID Detection</title><title>IEEE transactions on applied superconductivity</title><addtitle>TASC</addtitle><description>The contrast agents (CAs), which can enhance the image contrast by changing the relaxation times in the target locations, are widely used in clinical high-field magnetic resonance imaging (MRI). However, the commercial clinical CAs have attracted little attention in ultralow field (ULF) MRI, whose measurement field is four orders of magnitude lower than that of the clinical high-field counterpart. In this paper, we measure the relaxivity levels of three gadolinium (Gd)-based commercial CAs (Gd-DTPA, Gd-EOB-DTPA, and Gd-DTPA-BMA) with our four-channel magnetically unshielded ULF-MRI system using low-T c superconducting quantum interference devices as detectors. The system has a 0.65-T permanent-magnet pair as prepolarization field B p and applies a static B 0 field of 129 uT. We compare the longitudinal relaxivity levels of the CAs at B p and B 0 field strengths, as well as the reported values at 1.5 T. The results show that the relaxivity levels of three commercial CAs at 129 uT are all about twice those at high fields, which demonstrates one particular advantage of ULF-MRI.</description><subject>Contrast agents</subject><subject>Field strength</subject><subject>Gadolinium</subject><subject>Magnetic field measurement</subject><subject>Magnetic fields</subject><subject>Magnetic resonance imaging</subject><subject>MRI contrast agent</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Permanent magnets</subject><subject>relaxivity</subject><subject>SQUID</subject><subject>SQUIDs</subject><subject>Superconducting magnets</subject><subject>Superconducting quantum interference devices</subject><subject>Superconductivity</subject><subject>Transportation</subject><subject>ULF-MRI</subject><issn>1051-8223</issn><issn>1558-2515</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNpdkE1LAzEQhoMoWKs_QLwEvHjZmkk2u8mxbD8sFETa4jGkySzdsh91sz3037ulxYOnGZjnHWYeQp6BjQCYfl-PV9mIM0hGXEqpOb8hA5BSRVyCvO17JiFSnIt78hDCnjGIVSwHZDorsPR0ggesPdYO6ao7-hNtcpo1VYWtK2xJ555mOyxth4F-F92Orr42i0mf6tB1RVM_krvclgGfrnVINrPpOvuIlp_zRTZeRk7wpItixy1XW5syzZWWkFvFRQ6JtgnqmKPXHlns4lylKDXEVnhwznkUSm_7uRiSt8veQ9v8HDF0piqCw7K0NTbHYED13ycpMNGjr__QfXNs6_46A6lSQiUaoKfgQrm2CaHF3BzaorLtyQAzZ7HmLNacxZqr2D7zcskUiPjHp7FMOFPiF-_nceE</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Huang, Ruiqi</creator><creator>Tao, Quan</creator><creator>Chang, Baolin</creator><creator>Dong, Hui</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>F28</scope><scope>FR3</scope><orcidid>https://orcid.org/0000-0002-6444-1134</orcidid></search><sort><creationdate>20160801</creationdate><title>Field Dependence Study of Commercial Gd Chelates With SQUID Detection</title><author>Huang, Ruiqi ; Tao, Quan ; Chang, Baolin ; Dong, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-4c2a28ba70928951fa823f169a6e942ed9de04c4f87e5914a3d1cccde389b42e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Contrast agents</topic><topic>Field strength</topic><topic>Gadolinium</topic><topic>Magnetic field measurement</topic><topic>Magnetic fields</topic><topic>Magnetic resonance imaging</topic><topic>MRI contrast agent</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Permanent magnets</topic><topic>relaxivity</topic><topic>SQUID</topic><topic>SQUIDs</topic><topic>Superconducting magnets</topic><topic>Superconducting quantum interference devices</topic><topic>Superconductivity</topic><topic>Transportation</topic><topic>ULF-MRI</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Ruiqi</creatorcontrib><creatorcontrib>Tao, Quan</creatorcontrib><creatorcontrib>Chang, Baolin</creatorcontrib><creatorcontrib>Dong, Hui</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>IEEE transactions on applied superconductivity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Huang, Ruiqi</au><au>Tao, Quan</au><au>Chang, Baolin</au><au>Dong, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Field Dependence Study of Commercial Gd Chelates With SQUID Detection</atitle><jtitle>IEEE transactions on applied superconductivity</jtitle><stitle>TASC</stitle><date>2016-08-01</date><risdate>2016</risdate><volume>26</volume><issue>5</issue><spage>1</spage><epage>4</epage><pages>1-4</pages><issn>1051-8223</issn><eissn>1558-2515</eissn><coden>ITASE9</coden><abstract>The contrast agents (CAs), which can enhance the image contrast by changing the relaxation times in the target locations, are widely used in clinical high-field magnetic resonance imaging (MRI). However, the commercial clinical CAs have attracted little attention in ultralow field (ULF) MRI, whose measurement field is four orders of magnitude lower than that of the clinical high-field counterpart. In this paper, we measure the relaxivity levels of three gadolinium (Gd)-based commercial CAs (Gd-DTPA, Gd-EOB-DTPA, and Gd-DTPA-BMA) with our four-channel magnetically unshielded ULF-MRI system using low-T c superconducting quantum interference devices as detectors. The system has a 0.65-T permanent-magnet pair as prepolarization field B p and applies a static B 0 field of 129 uT. We compare the longitudinal relaxivity levels of the CAs at B p and B 0 field strengths, as well as the reported values at 1.5 T. The results show that the relaxivity levels of three commercial CAs at 129 uT are all about twice those at high fields, which demonstrates one particular advantage of ULF-MRI.</abstract><cop>New York</cop><pub>IEEE</pub><doi>10.1109/TASC.2016.2555922</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-6444-1134</orcidid></addata></record> |
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| subjects | Contrast agents Field strength Gadolinium Magnetic field measurement Magnetic fields Magnetic resonance imaging MRI contrast agent NMR Nuclear magnetic resonance Permanent magnets relaxivity SQUID SQUIDs Superconducting magnets Superconducting quantum interference devices Superconductivity Transportation ULF-MRI |
| title | Field Dependence Study of Commercial Gd Chelates With SQUID Detection |
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