Exact Identification of the Structure of a Probabilistic Boolean Network from Samples

We study the number of samples required to uniquely determine the structure of a probabilistic Boolean network (PBN), where PBNs are probabilistic extensions of Boolean networks. We show via theoretical analysis and computational analysis that the structure of a PBN can be exactly identified with hi...

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Veröffentlicht in:IEEE/ACM transactions on computational biology and bioinformatics 2016-11, Vol.13 (6), p.1107-1116
Hauptverfasser: Xiaoqing Cheng, Mori, Tomoya, Yushan Qiu, Wai-Ki Ching, Akutsu, Tatsuya
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Sprache:eng
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Zusammenfassung:We study the number of samples required to uniquely determine the structure of a probabilistic Boolean network (PBN), where PBNs are probabilistic extensions of Boolean networks. We show via theoretical analysis and computational analysis that the structure of a PBN can be exactly identified with high probability from a relatively small number of samples for interesting classes of PBNs of bounded indegree. On the other hand, we also show that there exist classes of PBNs for which it is impossible to uniquely determine the structure of a PBN from samples.
ISSN:1545-5963
1557-9964
DOI:10.1109/TCBB.2015.2505310