Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing
This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm 2 , which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement a...
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| creator | Bhalla, Nikhil Chung, Wen Yaw Danny Wang, Kerwin Lessmana, Teddy Estrela, Pedro |
| description | This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm 2 , which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0. |
| doi_str_mv | 10.1109/ICSENS.2013.6688201 |
| format | Conference Proceeding |
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| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1930-0395 |
| ispartof | 2013 IEEE SENSORS, 2013, p.1-4 |
| issn | 1930-0395 2168-9229 |
| language | eng |
| recordid | cdi_ieee_primary_6688201 |
| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Analytical chemistry Beads Chips Droplets Educational institutions Electrodes Immune system Immunoassay Magnetic particles Magnetic separation Microelectrodes Microfluidics Sensors Washing |
| title | Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing |
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