Layer detection in tissue engineering using an elasticity microscope
The authors have built a 50 MHz elasticity microscope to image tissue stiffness at fine resolution (better than 90 /spl mu/m). Elasticity micrographs are compared to histology from tissue engineered smooth muscle, grown from cultured cells and synthetic matrices. The top layer (100-300 /spl mu/m) de...
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| creator | Cohn, N.A. Emelianov, S.Y. Kim, B.-S. Mooney, D.J. Skovoroda, A.R. O'Donnell, M. |
| description | The authors have built a 50 MHz elasticity microscope to image tissue stiffness at fine resolution (better than 90 /spl mu/m). Elasticity micrographs are compared to histology from tissue engineered smooth muscle, grown from cultured cells and synthetic matrices. The top layer (100-300 /spl mu/m) develops into new tissue with high cell density. Tissue engineers would be greatly interested in noninvasively monitoring the extent of growth over time. Elasticity micrographs clearly differentiate viable cell layers from the synthetic matrix and necrotic cells. Histological differences between tissue engineered smooth muscle grown on a biodegradable matrix and cultured matrix without seeded cells confirm these results. |
| doi_str_mv | 10.1109/ULTSYM.1997.661846 |
| format | Conference Proceeding |
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Elasticity micrographs are compared to histology from tissue engineered smooth muscle, grown from cultured cells and synthetic matrices. The top layer (100-300 /spl mu/m) develops into new tissue with high cell density. Tissue engineers would be greatly interested in noninvasively monitoring the extent of growth over time. Elasticity micrographs clearly differentiate viable cell layers from the synthetic matrix and necrotic cells. Histological differences between tissue engineered smooth muscle grown on a biodegradable matrix and cultured matrix without seeded cells confirm these results.</description><identifier>ISSN: 1051-0117</identifier><identifier>ISBN: 0780341538</identifier><identifier>ISBN: 9780780341531</identifier><identifier>DOI: 10.1109/ULTSYM.1997.661846</identifier><language>eng</language><publisher>IEEE</publisher><subject>Biodegradation ; Biomedical engineering ; Biomedical measurements ; Cells ; Cells (biology) ; Computer science ; Elasticity ; Image analysis ; Image quality ; Medical imaging ; Microscopes ; Microscopy ; Monitoring ; Muscle ; Muscles ; Noninvasive medical procedures ; Stiffness ; Tissue engineering ; Ultrasonic imaging</subject><ispartof>1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. 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An International Symposium (Cat. No.97CH36118)</title><addtitle>ULTSYM</addtitle><description>The authors have built a 50 MHz elasticity microscope to image tissue stiffness at fine resolution (better than 90 /spl mu/m). Elasticity micrographs are compared to histology from tissue engineered smooth muscle, grown from cultured cells and synthetic matrices. The top layer (100-300 /spl mu/m) develops into new tissue with high cell density. Tissue engineers would be greatly interested in noninvasively monitoring the extent of growth over time. Elasticity micrographs clearly differentiate viable cell layers from the synthetic matrix and necrotic cells. Histological differences between tissue engineered smooth muscle grown on a biodegradable matrix and cultured matrix without seeded cells confirm these results.</description><subject>Biodegradation</subject><subject>Biomedical engineering</subject><subject>Biomedical measurements</subject><subject>Cells</subject><subject>Cells (biology)</subject><subject>Computer science</subject><subject>Elasticity</subject><subject>Image analysis</subject><subject>Image quality</subject><subject>Medical imaging</subject><subject>Microscopes</subject><subject>Microscopy</subject><subject>Monitoring</subject><subject>Muscle</subject><subject>Muscles</subject><subject>Noninvasive medical procedures</subject><subject>Stiffness</subject><subject>Tissue engineering</subject><subject>Ultrasonic imaging</subject><issn>1051-0117</issn><isbn>0780341538</isbn><isbn>9780780341531</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>1997</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNotkE1PhDAQhpuoiburf2BPPXkDpx9AOZr1M8F4cPfgiZQybGqgIC0H_r0YzJs87-XJZGYI2TOIGYP8_lQcP7_eY5bnWZymTMn0gmwhUyAkS4S6JBsGCYuAseyabL3_BuCQcLkhj4WecaQ1BjTB9o5aR4P1fkKK7mwd4mjdmU7-j9pRbLUP1tgw086asfemH_CGXDW69Xj73ztyen46Hl6j4uPl7fBQRJaDCBEXDde5rEwlZV4ly0pKoUEwQmjTVHxJoqECzRVrFi8FxZXOaimXg7K6ETtyt84dxv5nQh_KznqDbasd9pMvOROZXLCI-1W0iFgOo-30OJfrZ8QvkYZYqw</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Cohn, N.A.</creator><creator>Emelianov, S.Y.</creator><creator>Kim, B.-S.</creator><creator>Mooney, D.J.</creator><creator>Skovoroda, A.R.</creator><creator>O'Donnell, M.</creator><general>IEEE</general><scope>6IE</scope><scope>6IL</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIL</scope></search><sort><creationdate>1997</creationdate><title>Layer detection in tissue engineering using an elasticity microscope</title><author>Cohn, N.A. ; Emelianov, S.Y. ; Kim, B.-S. ; Mooney, D.J. ; Skovoroda, A.R. ; O'Donnell, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i203t-23f2a94bcb449b510588ece0c33acfb2b2b5a0b0a281f94b60828a7d448467df3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biodegradation</topic><topic>Biomedical engineering</topic><topic>Biomedical measurements</topic><topic>Cells</topic><topic>Cells (biology)</topic><topic>Computer science</topic><topic>Elasticity</topic><topic>Image analysis</topic><topic>Image quality</topic><topic>Medical imaging</topic><topic>Microscopes</topic><topic>Microscopy</topic><topic>Monitoring</topic><topic>Muscle</topic><topic>Muscles</topic><topic>Noninvasive medical procedures</topic><topic>Stiffness</topic><topic>Tissue engineering</topic><topic>Ultrasonic imaging</topic><toplevel>online_resources</toplevel><creatorcontrib>Cohn, N.A.</creatorcontrib><creatorcontrib>Emelianov, S.Y.</creatorcontrib><creatorcontrib>Kim, B.-S.</creatorcontrib><creatorcontrib>Mooney, D.J.</creatorcontrib><creatorcontrib>Skovoroda, A.R.</creatorcontrib><creatorcontrib>O'Donnell, M.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Xplore</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Cohn, N.A.</au><au>Emelianov, S.Y.</au><au>Kim, B.-S.</au><au>Mooney, D.J.</au><au>Skovoroda, A.R.</au><au>O'Donnell, M.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Layer detection in tissue engineering using an elasticity microscope</atitle><btitle>1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. No.97CH36118)</btitle><stitle>ULTSYM</stitle><date>1997</date><risdate>1997</risdate><volume>2</volume><spage>1431</spage><epage>1434 vol.2</epage><pages>1431-1434 vol.2</pages><issn>1051-0117</issn><isbn>0780341538</isbn><isbn>9780780341531</isbn><abstract>The authors have built a 50 MHz elasticity microscope to image tissue stiffness at fine resolution (better than 90 /spl mu/m). Elasticity micrographs are compared to histology from tissue engineered smooth muscle, grown from cultured cells and synthetic matrices. The top layer (100-300 /spl mu/m) develops into new tissue with high cell density. Tissue engineers would be greatly interested in noninvasively monitoring the extent of growth over time. Elasticity micrographs clearly differentiate viable cell layers from the synthetic matrix and necrotic cells. Histological differences between tissue engineered smooth muscle grown on a biodegradable matrix and cultured matrix without seeded cells confirm these results.</abstract><pub>IEEE</pub><doi>10.1109/ULTSYM.1997.661846</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1051-0117 |
| ispartof | 1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. No.97CH36118), 1997, Vol.2, p.1431-1434 vol.2 |
| issn | 1051-0117 |
| language | eng |
| recordid | cdi_ieee_primary_661846 |
| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Biodegradation Biomedical engineering Biomedical measurements Cells Cells (biology) Computer science Elasticity Image analysis Image quality Medical imaging Microscopes Microscopy Monitoring Muscle Muscles Noninvasive medical procedures Stiffness Tissue engineering Ultrasonic imaging |
| title | Layer detection in tissue engineering using an elasticity microscope |
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