Temperature-Dependent Terahertz Imaging of Excised Oral Malignant Melanoma
We imaged a single case of oral malignant melanoma using terahertz (THz) reflection imaging at room temperature (20 °C) and below freezing (-20 °C). A malignant nodule beneath the oral tissue surface was visualized using 2-D and B-scan THz imaging techniques. The THz images were well correlated with...
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| Veröffentlicht in: | IEEE journal of biomedical and health informatics 2013-07, Vol.17 (4), p.779-784 |
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| container_title | IEEE journal of biomedical and health informatics |
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| creator | Sim, Yookyeong Carolyn Ahn, Kang-Min Park, Jae Yeon Park, Chan-Sik Son, Joo-Hiuk |
| description | We imaged a single case of oral malignant melanoma using terahertz (THz) reflection imaging at room temperature (20 °C) and below freezing (-20 °C). A malignant nodule beneath the oral tissue surface was visualized using 2-D and B-scan THz imaging techniques. The THz images were well correlated with the histological findings. The nodule was found to have lower water content than that of normal cells, and this water effect may have influenced the THz refractive index and absorption coefficient at 20 °C. The THz spectroscopic image of the frozen tissue at -20 °C showed better contrast because of the lack of liquid water; this implies that there are significant structural differences between malignant oral melanoma cells and normal mucosal cells. The better contrast in the frozen tissue images was due to the greater penetration of THz radiation into the sample. This temperature-dependent THz imaging approach demonstrated the feasibility of accurate imaging of the oral tumor tissue. |
| doi_str_mv | 10.1109/JBHI.2013.2252357 |
| format | Article |
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A malignant nodule beneath the oral tissue surface was visualized using 2-D and B-scan THz imaging techniques. The THz images were well correlated with the histological findings. The nodule was found to have lower water content than that of normal cells, and this water effect may have influenced the THz refractive index and absorption coefficient at 20 °C. The THz spectroscopic image of the frozen tissue at -20 °C showed better contrast because of the lack of liquid water; this implies that there are significant structural differences between malignant oral melanoma cells and normal mucosal cells. The better contrast in the frozen tissue images was due to the greater penetration of THz radiation into the sample. 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(IEEE) Jul 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-542071159941587e3955adf7ec002e0da12eab44fae999d81b85f899ab8bd55c3</citedby><cites>FETCH-LOGICAL-c382t-542071159941587e3955adf7ec002e0da12eab44fae999d81b85f899ab8bd55c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/6509416$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,776,780,792,27903,27904,54736</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/6509416$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25055305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sim, Yookyeong Carolyn</creatorcontrib><creatorcontrib>Ahn, Kang-Min</creatorcontrib><creatorcontrib>Park, Jae Yeon</creatorcontrib><creatorcontrib>Park, Chan-Sik</creatorcontrib><creatorcontrib>Son, Joo-Hiuk</creatorcontrib><title>Temperature-Dependent Terahertz Imaging of Excised Oral Malignant Melanoma</title><title>IEEE journal of biomedical and health informatics</title><addtitle>JBHI</addtitle><addtitle>IEEE J Biomed Health Inform</addtitle><description>We imaged a single case of oral malignant melanoma using terahertz (THz) reflection imaging at room temperature (20 °C) and below freezing (-20 °C). 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Academic</collection><jtitle>IEEE journal of biomedical and health informatics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Sim, Yookyeong Carolyn</au><au>Ahn, Kang-Min</au><au>Park, Jae Yeon</au><au>Park, Chan-Sik</au><au>Son, Joo-Hiuk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temperature-Dependent Terahertz Imaging of Excised Oral Malignant Melanoma</atitle><jtitle>IEEE journal of biomedical and health informatics</jtitle><stitle>JBHI</stitle><addtitle>IEEE J Biomed Health Inform</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>17</volume><issue>4</issue><spage>779</spage><epage>784</epage><pages>779-784</pages><issn>2168-2194</issn><eissn>2168-2208</eissn><coden>IJBHA9</coden><abstract>We imaged a single case of oral malignant melanoma using terahertz (THz) reflection imaging at room temperature (20 °C) and below freezing (-20 °C). A malignant nodule beneath the oral tissue surface was visualized using 2-D and B-scan THz imaging techniques. The THz images were well correlated with the histological findings. The nodule was found to have lower water content than that of normal cells, and this water effect may have influenced the THz refractive index and absorption coefficient at 20 °C. The THz spectroscopic image of the frozen tissue at -20 °C showed better contrast because of the lack of liquid water; this implies that there are significant structural differences between malignant oral melanoma cells and normal mucosal cells. The better contrast in the frozen tissue images was due to the greater penetration of THz radiation into the sample. This temperature-dependent THz imaging approach demonstrated the feasibility of accurate imaging of the oral tumor tissue.</abstract><cop>United States</cop><pub>IEEE</pub><pmid>25055305</pmid><doi>10.1109/JBHI.2013.2252357</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Biomedical imaging Female Histocytochemistry Humans Image Processing, Computer-Assisted - methods Measurement by laser beam Medical imaging Melanoma Melanoma - chemistry Melanoma - pathology Mouth Mucosa - chemistry Mouth Mucosa - pathology Mouth Neoplasms - chemistry Mouth Neoplasms - pathology Temperature measurement terahertz (THz) imaging Terahertz Imaging - methods terahertz radiation Time-domain analysis |
| title | Temperature-Dependent Terahertz Imaging of Excised Oral Malignant Melanoma |
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