A Four-Layer Reference Model for Prediction of Protein Side-Chains Based on Dynamic Bayesian Networks

A four-layer reference model for prediction of protein side-chains based on Dynamic Bayesian Networks is proposed. The relation of backbone with four side chain torsion angles is considered in this model, and the problem caused by sparse data is resolved to a certain extent. Experiment shows that th...

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Hauptverfasser: Xu Huang, Qiang Lv, Dajun Miao, Peide Qian
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Qiang Lv
Dajun Miao
Peide Qian
description A four-layer reference model for prediction of protein side-chains based on Dynamic Bayesian Networks is proposed. The relation of backbone with four side chain torsion angles is considered in this model, and the problem caused by sparse data is resolved to a certain extent. Experiment shows that this method has produced a better DBN model and more exact prediction results. It indicates that the four-layer reference model is effective.
doi_str_mv 10.1109/ISCID.2012.193
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subjects Amino acids
Bayesian methods
Data models
Dynamic Bayesian Networks
Hidden Markov models
Prediction of Protein Structure
Prediction of Side-chain
Predictive models
Proteins
Training
title A Four-Layer Reference Model for Prediction of Protein Side-Chains Based on Dynamic Bayesian Networks
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