Drug release mechanisms of steroid eluting rings in cardiac pacemaker lead electrodes
This paper reports on the drug release mechanisms of silicone structures with embedded steroids applied in pacing leads. Different derivatives of the steroid dexamethasone, which is associated with the reduction of acute stimulation thresholds, were evaluated together with different matrix based rel...
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| container_volume | 2012 |
| creator | Herrlich, S. Spieth, S. Gerstmann, H. Virnich, A. Zipfel, F. Kitschmann, A. Goettsche, T. Osypka, P. Zengerle, R. |
| description | This paper reports on the drug release mechanisms of silicone structures with embedded steroids applied in pacing leads. Different derivatives of the steroid dexamethasone, which is associated with the reduction of acute stimulation thresholds, were evaluated together with different matrix based release control mechanisms with the target to potentially match optimal drug release rates during the first month after implantation. By incorporating dexamethasone-21-dihydrogen phosphate in silicone matrices in combination with release rate adaption layers, almost continuous release rates were obtained under physiological test settings. |
| doi_str_mv | 10.1109/EMBC.2012.6346023 |
| format | Conference Proceeding |
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Different derivatives of the steroid dexamethasone, which is associated with the reduction of acute stimulation thresholds, were evaluated together with different matrix based release control mechanisms with the target to potentially match optimal drug release rates during the first month after implantation. 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Different derivatives of the steroid dexamethasone, which is associated with the reduction of acute stimulation thresholds, were evaluated together with different matrix based release control mechanisms with the target to potentially match optimal drug release rates during the first month after implantation. By incorporating dexamethasone-21-dihydrogen phosphate in silicone matrices in combination with release rate adaption layers, almost continuous release rates were obtained under physiological test settings.</description><subject>Chromatography, High Pressure Liquid</subject><subject>Detectors</subject><subject>Dexamethasone - administration & dosage</subject><subject>Dexamethasone - analogs & derivatives</subject><subject>Dexamethasone - pharmacokinetics</subject><subject>Drug Delivery Systems</subject><subject>Drugs</subject><subject>Electrodes</subject><subject>Electrodes, Implanted</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Glucocorticoids - pharmacokinetics</subject><subject>Humans</subject><subject>Kinetic theory</subject><subject>Materials Testing</subject><subject>Microscopy, Electron, Scanning</subject><subject>Models, Biological</subject><subject>Pacemaker, Artificial</subject><subject>Pacemakers</subject><subject>Physiology</subject><subject>Silicones</subject><issn>1094-687X</issn><issn>1557-170X</issn><issn>1558-4615</issn><isbn>1424441196</isbn><isbn>9781424441198</isbn><isbn>9781457717871</isbn><isbn>1457717875</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2012</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRc1LtJR-AEJC_oEUT_xeQikPqYgNldhVjjMGQ5NWdrrg7wlqYRYzi3vuleYScgFsAsDs9ez5djopGZQTxYViJT8gY6sNCKk1aKPhkAxBSlMIBfKInIEohRAAVh33ArOiUEa_Dcg450_WjwHDmTglg5JzJa0RQ7K4S9t3mnCFLiNt0H-4NuYm03WgucO0jjXF1baLbU_1K9PYUu9SHZ2nG-excV-YaG__5dB3aV1jPicnwa0yjvd3RBb3s9fpYzF_eXia3swLz4XtClWj90ExV3MdpA8sKCtZKbWvvJMCqop55kIoa-ZFpUFVgRsrOPYFSA6aj8jVLnezrRqsl5sUG5e-l3__9cDlDoiI-C_v2-Q_iFJiGw</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Herrlich, S.</creator><creator>Spieth, S.</creator><creator>Gerstmann, H.</creator><creator>Virnich, A.</creator><creator>Zipfel, F.</creator><creator>Kitschmann, A.</creator><creator>Goettsche, T.</creator><creator>Osypka, P.</creator><creator>Zengerle, R.</creator><general>IEEE</general><scope>6IE</scope><scope>6IH</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIO</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20120101</creationdate><title>Drug release mechanisms of steroid eluting rings in cardiac pacemaker lead electrodes</title><author>Herrlich, S. ; Spieth, S. ; Gerstmann, H. ; Virnich, A. ; Zipfel, F. ; Kitschmann, A. ; Goettsche, T. ; Osypka, P. ; Zengerle, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-6deccf60ad37f5cf0f6950257cbca541bb0c0aff2d0c4b716bf38943e45753173</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Chromatography, High Pressure Liquid</topic><topic>Detectors</topic><topic>Dexamethasone - administration & dosage</topic><topic>Dexamethasone - analogs & derivatives</topic><topic>Dexamethasone - pharmacokinetics</topic><topic>Drug Delivery Systems</topic><topic>Drugs</topic><topic>Electrodes</topic><topic>Electrodes, Implanted</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Glucocorticoids - pharmacokinetics</topic><topic>Humans</topic><topic>Kinetic theory</topic><topic>Materials Testing</topic><topic>Microscopy, Electron, Scanning</topic><topic>Models, Biological</topic><topic>Pacemaker, Artificial</topic><topic>Pacemakers</topic><topic>Physiology</topic><topic>Silicones</topic><toplevel>online_resources</toplevel><creatorcontrib>Herrlich, S.</creatorcontrib><creatorcontrib>Spieth, S.</creatorcontrib><creatorcontrib>Gerstmann, H.</creatorcontrib><creatorcontrib>Virnich, A.</creatorcontrib><creatorcontrib>Zipfel, F.</creatorcontrib><creatorcontrib>Kitschmann, A.</creatorcontrib><creatorcontrib>Goettsche, T.</creatorcontrib><creatorcontrib>Osypka, P.</creatorcontrib><creatorcontrib>Zengerle, R.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan (POP) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP) 1998-present</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Herrlich, S.</au><au>Spieth, S.</au><au>Gerstmann, H.</au><au>Virnich, A.</au><au>Zipfel, F.</au><au>Kitschmann, A.</au><au>Goettsche, T.</au><au>Osypka, P.</au><au>Zengerle, R.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Drug release mechanisms of steroid eluting rings in cardiac pacemaker lead electrodes</atitle><btitle>2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society</btitle><stitle>EMBC</stitle><addtitle>Conf Proc IEEE Eng Med Biol Soc</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2012</volume><spage>681</spage><epage>684</epage><pages>681-684</pages><issn>1094-687X</issn><issn>1557-170X</issn><eissn>1558-4615</eissn><isbn>1424441196</isbn><isbn>9781424441198</isbn><eisbn>9781457717871</eisbn><eisbn>1457717875</eisbn><abstract>This paper reports on the drug release mechanisms of silicone structures with embedded steroids applied in pacing leads. Different derivatives of the steroid dexamethasone, which is associated with the reduction of acute stimulation thresholds, were evaluated together with different matrix based release control mechanisms with the target to potentially match optimal drug release rates during the first month after implantation. By incorporating dexamethasone-21-dihydrogen phosphate in silicone matrices in combination with release rate adaption layers, almost continuous release rates were obtained under physiological test settings.</abstract><cop>United States</cop><pub>IEEE</pub><pmid>23365984</pmid><doi>10.1109/EMBC.2012.6346023</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1094-687X |
| ispartof | 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2012, Vol.2012, p.681-684 |
| issn | 1094-687X 1557-170X 1558-4615 |
| language | eng |
| recordid | cdi_ieee_primary_6346023 |
| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Chromatography, High Pressure Liquid Detectors Dexamethasone - administration & dosage Dexamethasone - analogs & derivatives Dexamethasone - pharmacokinetics Drug Delivery Systems Drugs Electrodes Electrodes, Implanted Glucocorticoids - administration & dosage Glucocorticoids - pharmacokinetics Humans Kinetic theory Materials Testing Microscopy, Electron, Scanning Models, Biological Pacemaker, Artificial Pacemakers Physiology Silicones |
| title | Drug release mechanisms of steroid eluting rings in cardiac pacemaker lead electrodes |
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