Motion compensation method for quantification of neovascularization in carotid atherosclerotic plaques with contrast enhanced ultrasound (CEUS)

Several studies have linked intraplaque neovascularization (IPN) with progressive atherosclerotic disease and plaque instability. An accurate quantification of IPN may allow early detection of vulnerable plaques. In this study, a dedicated motion compensation method was developed for quantification of IPN in small plaques (; 2 pixels from true motion in any frame. Tracking was scored as fully successful in 52 MIS (78%). The proposed motion tracking is sufficiently accurate and successful for in vivo application.