Differential evolution-binary particle swarm optimization algorithm for the analysis of aryl β-diketo acids for HIV-1 integrase inhibition
A hybrid differential evolution-binary particle swarm optimization (DE-BPSO) algorithm is proposed as a feature selection algorithm in the development of quantitative structure-activity relationship (QSAR) models. DE is used to evolve the velocities of the particle swarm from which a series of rules...
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| creator | Ko, G. M. Srinivas Reddy, A. Kumar, S. Garg, R. Bailey, B. A. Hadaegh, A. R. |
| description | A hybrid differential evolution-binary particle swarm optimization (DE-BPSO) algorithm is proposed as a feature selection algorithm in the development of quantitative structure-activity relationship (QSAR) models. DE is used to evolve the velocities of the particle swarm from which a series of rules are used to determine the discrete values of the position vectors which form chemical descriptor subsets. These descriptor subsets are then used to develop models for QSAR analysis. DE-BPSO was found to outperform the standalone BPSO algorithm. The DE-BPSO algorithm was then used to develop multiple linear regression models for the analysis of aryl β-diketo acid compounds for the inhibition of HIV-1 integrase. This model highlights the significance of hydrophobicity and partial positive charges of the hydrogen atoms on the molecular surface in influencing the biological activities of these compounds for the inhibition of HIV-1 integrase. |
| doi_str_mv | 10.1109/CEC.2012.6256578 |
| format | Conference Proceeding |
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R.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Ko, G. M.</au><au>Srinivas Reddy, A.</au><au>Kumar, S.</au><au>Garg, R.</au><au>Bailey, B. A.</au><au>Hadaegh, A. 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| identifier | ISSN: 1089-778X |
| ispartof | 2012 IEEE Congress on Evolutionary Computation, 2012, p.1-7 |
| issn | 1089-778X 1941-0026 |
| language | eng |
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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Analytical models Biological system modeling Chemicals Compounds Computational modeling Optimization Vectors |
| title | Differential evolution-binary particle swarm optimization algorithm for the analysis of aryl β-diketo acids for HIV-1 integrase inhibition |
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