A Hybrid Electrokinetic-Microfluidic Chip for Isolating CTCs in Physiological Sample
This paper reports a hybrid electrokinetic-microfluidic chip, which combines electrophoresis (EP), dielectrophoresis (DEP) or AC electrothermal flow (ACEF), for isolating circulating tumor cells (CTCs) in physiological sample. While most electrokinetic techniques only function in low-conductivity bu...
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| creator | Yu Liu Ningning Song Juan Dang Hairong Chen Dong Yang Jian Gao Dajun Song Tianzhu Yang Hongxiao Tian |
| description | This paper reports a hybrid electrokinetic-microfluidic chip, which combines electrophoresis (EP), dielectrophoresis (DEP) or AC electrothermal flow (ACEF), for isolating circulating tumor cells (CTCs) in physiological sample. While most electrokinetic techniques only function in low-conductivity buffers, hybrid electrokinetics enables effective operation in high-conductivity samples (1 S/m), which are compatible to physiological fluids such as blood, buffy coat and urine. Using a 3-electrode configuration and optimizing AC voltage, frequency and DC offset, we demonstrate that breast cancer cell can be localized within 10 sec in buffy coat without any pretreatment. |
| doi_str_mv | 10.1109/iCBEB.2012.27 |
| format | Conference Proceeding |
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While most electrokinetic techniques only function in low-conductivity buffers, hybrid electrokinetics enables effective operation in high-conductivity samples (1 S/m), which are compatible to physiological fluids such as blood, buffy coat and urine. Using a 3-electrode configuration and optimizing AC voltage, frequency and DC offset, we demonstrate that breast cancer cell can be localized within 10 sec in buffy coat without any pretreatment.</description><identifier>ISBN: 1457719878</identifier><identifier>ISBN: 9781457719875</identifier><identifier>EISBN: 9780769547060</identifier><identifier>EISBN: 0769547060</identifier><identifier>DOI: 10.1109/iCBEB.2012.27</identifier><language>eng</language><publisher>IEEE</publisher><subject>bioprocessor ; Blood ; Cancer ; CTCs ; Electric fields ; Electrodes ; electrokinetic ; Electrokinetics ; microfluidic chip ; Microfluidics ; Physiology</subject><ispartof>2012 International Conference on Biomedical Engineering and Biotechnology, 2012, p.962-964</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/6245282$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>309,310,776,780,785,786,2052,27902,54895</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/6245282$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Yu Liu</creatorcontrib><creatorcontrib>Ningning Song</creatorcontrib><creatorcontrib>Juan Dang</creatorcontrib><creatorcontrib>Hairong Chen</creatorcontrib><creatorcontrib>Dong Yang</creatorcontrib><creatorcontrib>Jian Gao</creatorcontrib><creatorcontrib>Dajun Song</creatorcontrib><creatorcontrib>Tianzhu Yang</creatorcontrib><creatorcontrib>Hongxiao Tian</creatorcontrib><title>A Hybrid Electrokinetic-Microfluidic Chip for Isolating CTCs in Physiological Sample</title><title>2012 International Conference on Biomedical Engineering and Biotechnology</title><addtitle>icbeb</addtitle><description>This paper reports a hybrid electrokinetic-microfluidic chip, which combines electrophoresis (EP), dielectrophoresis (DEP) or AC electrothermal flow (ACEF), for isolating circulating tumor cells (CTCs) in physiological sample. While most electrokinetic techniques only function in low-conductivity buffers, hybrid electrokinetics enables effective operation in high-conductivity samples (1 S/m), which are compatible to physiological fluids such as blood, buffy coat and urine. Using a 3-electrode configuration and optimizing AC voltage, frequency and DC offset, we demonstrate that breast cancer cell can be localized within 10 sec in buffy coat without any pretreatment.</description><subject>bioprocessor</subject><subject>Blood</subject><subject>Cancer</subject><subject>CTCs</subject><subject>Electric fields</subject><subject>Electrodes</subject><subject>electrokinetic</subject><subject>Electrokinetics</subject><subject>microfluidic chip</subject><subject>Microfluidics</subject><subject>Physiology</subject><isbn>1457719878</isbn><isbn>9781457719875</isbn><isbn>9780769547060</isbn><isbn>0769547060</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2012</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNotjL1OwzAYAI0QElAyMrH4BRJsx_aXjG0UaKUikMheOf5pP3CTKAlD3p5KcMsNJx0hj5xlnLPyGatNvckE4yITcEWSEgoGulQSmGbX5J5LBcDLAopbkkzTF7sABWdK35FmTbdLO6KjdfR2Hvtv7PyMNn1DO_Yh_qBDS6sTDjT0I91NfTQzdkdaNdVEsaMfp2XCPvZHtCbST3Meon8gN8HEySf_XpHmpW6qbbp_f91V632KJZvTXDNpW7CSq6A5BCdEG1pneK6Ya4V1rQmGB9BBCDCFY0YqBSHkkl8auHxFnv626L0_DCOezbgctJBKFCL_BaKjUVE</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Yu Liu</creator><creator>Ningning Song</creator><creator>Juan Dang</creator><creator>Hairong Chen</creator><creator>Dong Yang</creator><creator>Jian Gao</creator><creator>Dajun Song</creator><creator>Tianzhu Yang</creator><creator>Hongxiao Tian</creator><general>IEEE</general><scope>6IE</scope><scope>6IL</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIL</scope></search><sort><creationdate>201205</creationdate><title>A Hybrid Electrokinetic-Microfluidic Chip for Isolating CTCs in Physiological Sample</title><author>Yu Liu ; Ningning Song ; Juan Dang ; Hairong Chen ; Dong Yang ; Jian Gao ; Dajun Song ; Tianzhu Yang ; Hongxiao Tian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i90t-3604cb7c415f617fd22bfbda1350db2cdbafa1f76f227a8d0a4557ff341cdb7d3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2012</creationdate><topic>bioprocessor</topic><topic>Blood</topic><topic>Cancer</topic><topic>CTCs</topic><topic>Electric fields</topic><topic>Electrodes</topic><topic>electrokinetic</topic><topic>Electrokinetics</topic><topic>microfluidic chip</topic><topic>Microfluidics</topic><topic>Physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Yu Liu</creatorcontrib><creatorcontrib>Ningning Song</creatorcontrib><creatorcontrib>Juan Dang</creatorcontrib><creatorcontrib>Hairong Chen</creatorcontrib><creatorcontrib>Dong Yang</creatorcontrib><creatorcontrib>Jian Gao</creatorcontrib><creatorcontrib>Dajun Song</creatorcontrib><creatorcontrib>Tianzhu Yang</creatorcontrib><creatorcontrib>Hongxiao Tian</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Yu Liu</au><au>Ningning Song</au><au>Juan Dang</au><au>Hairong Chen</au><au>Dong Yang</au><au>Jian Gao</au><au>Dajun Song</au><au>Tianzhu Yang</au><au>Hongxiao Tian</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>A Hybrid Electrokinetic-Microfluidic Chip for Isolating CTCs in Physiological Sample</atitle><btitle>2012 International Conference on Biomedical Engineering and Biotechnology</btitle><stitle>icbeb</stitle><date>2012-05</date><risdate>2012</risdate><spage>962</spage><epage>964</epage><pages>962-964</pages><isbn>1457719878</isbn><isbn>9781457719875</isbn><eisbn>9780769547060</eisbn><eisbn>0769547060</eisbn><abstract>This paper reports a hybrid electrokinetic-microfluidic chip, which combines electrophoresis (EP), dielectrophoresis (DEP) or AC electrothermal flow (ACEF), for isolating circulating tumor cells (CTCs) in physiological sample. While most electrokinetic techniques only function in low-conductivity buffers, hybrid electrokinetics enables effective operation in high-conductivity samples (1 S/m), which are compatible to physiological fluids such as blood, buffy coat and urine. Using a 3-electrode configuration and optimizing AC voltage, frequency and DC offset, we demonstrate that breast cancer cell can be localized within 10 sec in buffy coat without any pretreatment.</abstract><pub>IEEE</pub><doi>10.1109/iCBEB.2012.27</doi><tpages>3</tpages></addata></record> |
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| identifier | ISBN: 1457719878 |
| ispartof | 2012 International Conference on Biomedical Engineering and Biotechnology, 2012, p.962-964 |
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| language | eng |
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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | bioprocessor Blood Cancer CTCs Electric fields Electrodes electrokinetic Electrokinetics microfluidic chip Microfluidics Physiology |
| title | A Hybrid Electrokinetic-Microfluidic Chip for Isolating CTCs in Physiological Sample |
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