Application of Micro-Computed Tomography With Iodine Staining to Cardiac Imaging, Segmentation, and Computational Model Development
Micro-computed tomography (micro-CT) has been widely used to generate high-resolution 3-D tissue images from small animals nondestructively, especially for mineralized skeletal tissues. However, its application to the analysis of soft cardiovascular tissues has been limited by poor inter-tissue cont...
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| creator | Aslanidi, O. V. Nikolaidou, T. Jichao Zhao Smaill, B. H. Gilbert, S. H. Holden, A. V. Lowe, T. Withers, P. J. Stephenson, R. S. Jarvis, J. C. Hancox, J. C. Boyett, M. R. Henggui Zhang |
| description | Micro-computed tomography (micro-CT) has been widely used to generate high-resolution 3-D tissue images from small animals nondestructively, especially for mineralized skeletal tissues. However, its application to the analysis of soft cardiovascular tissues has been limited by poor inter-tissue contrast. Recent ex vivo studies have shown that contrast between muscular and connective tissue in micro-CT images can be enhanced by staining with iodine. In the present study, we apply this novel technique for imaging of cardiovascular structures in canine hearts. We optimize the method to obtain high-resolution X-ray micro-CT images of the canine atria and its distinctive regions-including the Bachmann's bundle, atrioventricular node, pulmonary arteries and veins-with clear inter-tissue contrast. The imaging results are used to reconstruct and segment the detailed 3-D geometry of the atria. Structure tensor analysis shows that the arrangement of atrial fibers can also be characterized using the enhanced micro-CT images, as iodine preferentially accumulates within the muscular fibers rather than in connective tissues. This novel technique can be particularly useful in nondestructive imaging of 3-D cardiac architectures from large animals and humans, due to the combination of relatively high speed ( ~ 1 h/per scan of the large canine heart) and high voxel resolution (36 μm) provided. In summary, contrast micro-CT facilitates fast and nondestructive imaging and segmenting of detailed 3-D cardiovascular geometries, as well as measuring fiber orientation, which are crucial in constructing biophysically detailed computational cardiac models. |
| doi_str_mv | 10.1109/TMI.2012.2209183 |
| format | Article |
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V. ; Nikolaidou, T. ; Jichao Zhao ; Smaill, B. H. ; Gilbert, S. H. ; Holden, A. V. ; Lowe, T. ; Withers, P. J. ; Stephenson, R. S. ; Jarvis, J. C. ; Hancox, J. C. ; Boyett, M. R. ; Henggui Zhang</creator><creatorcontrib>Aslanidi, O. V. ; Nikolaidou, T. ; Jichao Zhao ; Smaill, B. H. ; Gilbert, S. H. ; Holden, A. V. ; Lowe, T. ; Withers, P. J. ; Stephenson, R. S. ; Jarvis, J. C. ; Hancox, J. C. ; Boyett, M. R. ; Henggui Zhang</creatorcontrib><description>Micro-computed tomography (micro-CT) has been widely used to generate high-resolution 3-D tissue images from small animals nondestructively, especially for mineralized skeletal tissues. However, its application to the analysis of soft cardiovascular tissues has been limited by poor inter-tissue contrast. Recent ex vivo studies have shown that contrast between muscular and connective tissue in micro-CT images can be enhanced by staining with iodine. In the present study, we apply this novel technique for imaging of cardiovascular structures in canine hearts. We optimize the method to obtain high-resolution X-ray micro-CT images of the canine atria and its distinctive regions-including the Bachmann's bundle, atrioventricular node, pulmonary arteries and veins-with clear inter-tissue contrast. The imaging results are used to reconstruct and segment the detailed 3-D geometry of the atria. Structure tensor analysis shows that the arrangement of atrial fibers can also be characterized using the enhanced micro-CT images, as iodine preferentially accumulates within the muscular fibers rather than in connective tissues. This novel technique can be particularly useful in nondestructive imaging of 3-D cardiac architectures from large animals and humans, due to the combination of relatively high speed ( ~ 1 h/per scan of the large canine heart) and high voxel resolution (36 μm) provided. In summary, contrast micro-CT facilitates fast and nondestructive imaging and segmenting of detailed 3-D cardiovascular geometries, as well as measuring fiber orientation, which are crucial in constructing biophysically detailed computational cardiac models.</description><identifier>ISSN: 0278-0062</identifier><identifier>ISSN: 1558-254X</identifier><identifier>EISSN: 1558-254X</identifier><identifier>DOI: 10.1109/TMI.2012.2209183</identifier><identifier>PMID: 22829390</identifier><identifier>CODEN: ITMID4</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Animal models and imaging ; Animals ; Biomedical imaging ; Contrast Media - chemistry ; Coronary Vessels - anatomy & histology ; Coronary Vessels - diagnostic imaging ; Dogs ; Female ; Geometry ; Heart ; Heart - anatomy & histology ; Heart - diagnostic imaging ; Image reconstruction ; Image segmentation ; Imaging, Three-Dimensional - methods ; Iodine Compounds - chemistry ; Medical imaging ; Models, Cardiovascular ; Optical fiber cables ; Pulmonary arteries ; Studies ; tissue modelling ; X-ray imaging and computed tomography ; X-Ray Microtomography - methods</subject><ispartof>IEEE transactions on medical imaging, 2013-01, Vol.32 (1), p.8-17</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. 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H.</creatorcontrib><creatorcontrib>Gilbert, S. H.</creatorcontrib><creatorcontrib>Holden, A. V.</creatorcontrib><creatorcontrib>Lowe, T.</creatorcontrib><creatorcontrib>Withers, P. J.</creatorcontrib><creatorcontrib>Stephenson, R. S.</creatorcontrib><creatorcontrib>Jarvis, J. C.</creatorcontrib><creatorcontrib>Hancox, J. C.</creatorcontrib><creatorcontrib>Boyett, M. R.</creatorcontrib><creatorcontrib>Henggui Zhang</creatorcontrib><title>Application of Micro-Computed Tomography With Iodine Staining to Cardiac Imaging, Segmentation, and Computational Model Development</title><title>IEEE transactions on medical imaging</title><addtitle>TMI</addtitle><addtitle>IEEE Trans Med Imaging</addtitle><description>Micro-computed tomography (micro-CT) has been widely used to generate high-resolution 3-D tissue images from small animals nondestructively, especially for mineralized skeletal tissues. However, its application to the analysis of soft cardiovascular tissues has been limited by poor inter-tissue contrast. Recent ex vivo studies have shown that contrast between muscular and connective tissue in micro-CT images can be enhanced by staining with iodine. In the present study, we apply this novel technique for imaging of cardiovascular structures in canine hearts. We optimize the method to obtain high-resolution X-ray micro-CT images of the canine atria and its distinctive regions-including the Bachmann's bundle, atrioventricular node, pulmonary arteries and veins-with clear inter-tissue contrast. The imaging results are used to reconstruct and segment the detailed 3-D geometry of the atria. Structure tensor analysis shows that the arrangement of atrial fibers can also be characterized using the enhanced micro-CT images, as iodine preferentially accumulates within the muscular fibers rather than in connective tissues. This novel technique can be particularly useful in nondestructive imaging of 3-D cardiac architectures from large animals and humans, due to the combination of relatively high speed ( ~ 1 h/per scan of the large canine heart) and high voxel resolution (36 μm) provided. In summary, contrast micro-CT facilitates fast and nondestructive imaging and segmenting of detailed 3-D cardiovascular geometries, as well as measuring fiber orientation, which are crucial in constructing biophysically detailed computational cardiac models.</description><subject>Animal models and imaging</subject><subject>Animals</subject><subject>Biomedical imaging</subject><subject>Contrast Media - chemistry</subject><subject>Coronary Vessels - anatomy & histology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Dogs</subject><subject>Female</subject><subject>Geometry</subject><subject>Heart</subject><subject>Heart - anatomy & histology</subject><subject>Heart - diagnostic imaging</subject><subject>Image reconstruction</subject><subject>Image segmentation</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Iodine Compounds - chemistry</subject><subject>Medical imaging</subject><subject>Models, Cardiovascular</subject><subject>Optical fiber cables</subject><subject>Pulmonary arteries</subject><subject>Studies</subject><subject>tissue modelling</subject><subject>X-ray imaging and computed tomography</subject><subject>X-Ray Microtomography - methods</subject><issn>0278-0062</issn><issn>1558-254X</issn><issn>1558-254X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ESBDL</sourceid><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0EokvhjoSELHHh0CzjcezEF6Rq-VqpKw5dBDfLiZ1dV0mc5qNSz_xxnO6yAi6cRpp55p2x5yXkJYMlY6DebTfrJQLDJSIolvNHZMGEyBMU6Y_HZAGY5QmAxDPybBhuAFgqQD0lZ4g5Kq5gQX5edl3tSzP60NJQ0Y0v-5CsQtNNo7N0G5qw6023v6ff_bin62B96-j1aHzr2x0dA12Z3npT0nVjdjF1Qa_drnHt-CB5QU1r6UHuIWFqugnW1fSDu3N16GbyOXlSmXpwL47xnHz79HG7-pJcff28Xl1eJWWaZWOSc1UJaQppDUhlhXQ8tzavpCsLWyHjVVZJowBynJECWFkA2AzRmlRWjp-T9wfdbioaZ8s4uje17nrfmP5eB-P135XW7_Uu3GmeKp7KLAq8PQr04XZyw6gbP5Surk3rwjRoxgWiAsbZ_1HMOAJykUb0zT_oTZj6-FMzJRWoTAkVKThQ8T7D0LvqtDcDPZtBRzPo2Qz6aIbY8vrP954afl8_Aq8OgHfOncoSU0yZ4L8AYmu6oA</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Aslanidi, O. 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V.</au><au>Nikolaidou, T.</au><au>Jichao Zhao</au><au>Smaill, B. H.</au><au>Gilbert, S. H.</au><au>Holden, A. V.</au><au>Lowe, T.</au><au>Withers, P. J.</au><au>Stephenson, R. S.</au><au>Jarvis, J. C.</au><au>Hancox, J. C.</au><au>Boyett, M. R.</au><au>Henggui Zhang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of Micro-Computed Tomography With Iodine Staining to Cardiac Imaging, Segmentation, and Computational Model Development</atitle><jtitle>IEEE transactions on medical imaging</jtitle><stitle>TMI</stitle><addtitle>IEEE Trans Med Imaging</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>32</volume><issue>1</issue><spage>8</spage><epage>17</epage><pages>8-17</pages><issn>0278-0062</issn><issn>1558-254X</issn><eissn>1558-254X</eissn><coden>ITMID4</coden><abstract>Micro-computed tomography (micro-CT) has been widely used to generate high-resolution 3-D tissue images from small animals nondestructively, especially for mineralized skeletal tissues. However, its application to the analysis of soft cardiovascular tissues has been limited by poor inter-tissue contrast. Recent ex vivo studies have shown that contrast between muscular and connective tissue in micro-CT images can be enhanced by staining with iodine. In the present study, we apply this novel technique for imaging of cardiovascular structures in canine hearts. We optimize the method to obtain high-resolution X-ray micro-CT images of the canine atria and its distinctive regions-including the Bachmann's bundle, atrioventricular node, pulmonary arteries and veins-with clear inter-tissue contrast. The imaging results are used to reconstruct and segment the detailed 3-D geometry of the atria. Structure tensor analysis shows that the arrangement of atrial fibers can also be characterized using the enhanced micro-CT images, as iodine preferentially accumulates within the muscular fibers rather than in connective tissues. This novel technique can be particularly useful in nondestructive imaging of 3-D cardiac architectures from large animals and humans, due to the combination of relatively high speed ( ~ 1 h/per scan of the large canine heart) and high voxel resolution (36 μm) provided. In summary, contrast micro-CT facilitates fast and nondestructive imaging and segmenting of detailed 3-D cardiovascular geometries, as well as measuring fiber orientation, which are crucial in constructing biophysically detailed computational cardiac models.</abstract><cop>United States</cop><pub>IEEE</pub><pmid>22829390</pmid><doi>10.1109/TMI.2012.2209183</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal models and imaging Animals Biomedical imaging Contrast Media - chemistry Coronary Vessels - anatomy & histology Coronary Vessels - diagnostic imaging Dogs Female Geometry Heart Heart - anatomy & histology Heart - diagnostic imaging Image reconstruction Image segmentation Imaging, Three-Dimensional - methods Iodine Compounds - chemistry Medical imaging Models, Cardiovascular Optical fiber cables Pulmonary arteries Studies tissue modelling X-ray imaging and computed tomography X-Ray Microtomography - methods |
| title | Application of Micro-Computed Tomography With Iodine Staining to Cardiac Imaging, Segmentation, and Computational Model Development |
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