Control of the inflammatory response with poly(trolox ester) antioxidant nanoparticles

Control of the inflammatory response with poly(trolox ester) antioxidant nanoparticles

Poly(trolox ester) nanoparticles were screened for anti-inflammatory properties on two different rheumatoid arthritis cell lines. Trolox was polymerized to two different molecular weights and formed into nanoparticles, which were added to cultures of interleukin-1β stimulated MH7A synovial fibroblas...

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Bibliographische Detailangaben
Hauptverfasser: Wardwell, P., Wattamwar, P., Dziubla, T., Bader, R.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Arthritis
Degradation
Diseases
Media
Nanoparticles
Polymers
Stress
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Beschreibung
Zusammenfassung:Poly(trolox ester) nanoparticles were screened for anti-inflammatory properties on two different rheumatoid arthritis cell lines. Trolox was polymerized to two different molecular weights and formed into nanoparticles, which were added to cultures of interleukin-1β stimulated MH7A synovial fibroblast cells and macrophage-like U937 cells. Poly(trolox ester) nanoparticles effectively reduced the secretion of pro-inflammatory mediators by both cell types.
ISSN:2160-6986
2160-7028
DOI:10.1109/NEBC.2012.6207082