Effects of surface functional groups on the aggregation stability of magnetite nanoparticles in biological media containing serum
Size stability of magnetite nanoparticles (MNP) with different surface functional groups in biological media was achieved by the addition of fetal bovine serum (FBS). The stability of the particles was attributed to the formation of protein coronas around the particles, which provides sufficient ste...
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| creator | Wiogo, H. T. R. Lim, M. Bulmus, V. Amal, R. |
| description | Size stability of magnetite nanoparticles (MNP) with different surface functional groups in biological media was achieved by the addition of fetal bovine serum (FBS). The stability of the particles was attributed to the formation of protein coronas around the particles, which provides sufficient steric hindrance to prevent aggregation of the particles. The stability of different modified MNP were also studied in biological media containing bovine serum albumin (BSA) to further understand the stabilization mechanism. BSA was found to stabilize polyethyleneimine (PEI) modified MNP and polymethacrylic acid (PMAA) coated MNP, but not the bare MNP. These results indicate a difference in interactions between serum protein and the MNP that is govern by the type of functional groups on the MNP surface, with positively charged surface groups resulting higher protein adsorption and better stability. |
| doi_str_mv | 10.1109/NANO.2011.6144499 |
| format | Conference Proceeding |
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T. R. ; Lim, M. ; Bulmus, V. ; Amal, R.</creator><creatorcontrib>Wiogo, H. T. R. ; Lim, M. ; Bulmus, V. ; Amal, R.</creatorcontrib><description>Size stability of magnetite nanoparticles (MNP) with different surface functional groups in biological media was achieved by the addition of fetal bovine serum (FBS). The stability of the particles was attributed to the formation of protein coronas around the particles, which provides sufficient steric hindrance to prevent aggregation of the particles. The stability of different modified MNP were also studied in biological media containing bovine serum albumin (BSA) to further understand the stabilization mechanism. BSA was found to stabilize polyethyleneimine (PEI) modified MNP and polymethacrylic acid (PMAA) coated MNP, but not the bare MNP. 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T. R.</creatorcontrib><creatorcontrib>Lim, M.</creatorcontrib><creatorcontrib>Bulmus, V.</creatorcontrib><creatorcontrib>Amal, R.</creatorcontrib><title>Effects of surface functional groups on the aggregation stability of magnetite nanoparticles in biological media containing serum</title><title>2011 11th IEEE International Conference on Nanotechnology</title><addtitle>NANO</addtitle><description>Size stability of magnetite nanoparticles (MNP) with different surface functional groups in biological media was achieved by the addition of fetal bovine serum (FBS). The stability of the particles was attributed to the formation of protein coronas around the particles, which provides sufficient steric hindrance to prevent aggregation of the particles. The stability of different modified MNP were also studied in biological media containing bovine serum albumin (BSA) to further understand the stabilization mechanism. BSA was found to stabilize polyethyleneimine (PEI) modified MNP and polymethacrylic acid (PMAA) coated MNP, but not the bare MNP. These results indicate a difference in interactions between serum protein and the MNP that is govern by the type of functional groups on the MNP surface, with positively charged surface groups resulting higher protein adsorption and better stability.</description><subject>Albumin</subject><subject>Gel electrophoresis</subject><subject>Magnetite nanoparticles</subject><subject>Media</subject><subject>Nanoparticles</subject><subject>Protein corona</subject><subject>Protein engineering</subject><subject>Proteins</subject><subject>Serum</subject><subject>Stability criteria</subject><subject>Stabilization</subject><issn>1944-9399</issn><issn>1944-9380</issn><isbn>9781457715143</isbn><isbn>1457715147</isbn><isbn>9781457715167</isbn><isbn>1457715163</isbn><isbn>1457715155</isbn><isbn>9781457715150</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2011</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNpVkMtqwzAQRdU2gYY0H1C60Q84lSJZj2UIfUFINtkHWRq5KrYcLHmRZf-8Dg2FzuYyHObAHYQeKVlSSvTzbr3bL1eE0qWgnHOtb9BCS0V5KSUtqZC3aEY154Vmitz9Y5xN_pjWUzS5aO7RIqUvMo4QmhM6Q98v3oPNCXcep6H3xgL2Q7Q5dNE0uO674TTCiPMnYFPXPdTmwnDKpgpNyOfLZWvqCDlkwNHE7mT6HGwDCYeIq9A1XR3sKGvBBYNtF7MJMcQaJ-iH9gFNvWkSLK45R4fXl8Pmvdju3z42620RNMmFhLG_AyWYJZ45rSpYKVcqrty4iLIkwIBKEFYpR0ojXSW5YdxZYQUDwebo6VcbAOB46kNr-vPx-lb2AyUzaN0</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Wiogo, H. T. R.</creator><creator>Lim, M.</creator><creator>Bulmus, V.</creator><creator>Amal, R.</creator><general>IEEE</general><scope>6IE</scope><scope>6IL</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIL</scope></search><sort><creationdate>201108</creationdate><title>Effects of surface functional groups on the aggregation stability of magnetite nanoparticles in biological media containing serum</title><author>Wiogo, H. T. 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R.</creatorcontrib><creatorcontrib>Lim, M.</creatorcontrib><creatorcontrib>Bulmus, V.</creatorcontrib><creatorcontrib>Amal, R.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Wiogo, H. T. R.</au><au>Lim, M.</au><au>Bulmus, V.</au><au>Amal, R.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Effects of surface functional groups on the aggregation stability of magnetite nanoparticles in biological media containing serum</atitle><btitle>2011 11th IEEE International Conference on Nanotechnology</btitle><stitle>NANO</stitle><date>2011-08</date><risdate>2011</risdate><spage>841</spage><epage>844</epage><pages>841-844</pages><issn>1944-9399</issn><eissn>1944-9380</eissn><isbn>9781457715143</isbn><isbn>1457715147</isbn><eisbn>9781457715167</eisbn><eisbn>1457715163</eisbn><eisbn>1457715155</eisbn><eisbn>9781457715150</eisbn><abstract>Size stability of magnetite nanoparticles (MNP) with different surface functional groups in biological media was achieved by the addition of fetal bovine serum (FBS). The stability of the particles was attributed to the formation of protein coronas around the particles, which provides sufficient steric hindrance to prevent aggregation of the particles. The stability of different modified MNP were also studied in biological media containing bovine serum albumin (BSA) to further understand the stabilization mechanism. BSA was found to stabilize polyethyleneimine (PEI) modified MNP and polymethacrylic acid (PMAA) coated MNP, but not the bare MNP. These results indicate a difference in interactions between serum protein and the MNP that is govern by the type of functional groups on the MNP surface, with positively charged surface groups resulting higher protein adsorption and better stability.</abstract><pub>IEEE</pub><doi>10.1109/NANO.2011.6144499</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1944-9399 |
| ispartof | 2011 11th IEEE International Conference on Nanotechnology, 2011, p.841-844 |
| issn | 1944-9399 1944-9380 |
| language | eng |
| recordid | cdi_ieee_primary_6144499 |
| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Albumin Gel electrophoresis Magnetite nanoparticles Media Nanoparticles Protein corona Protein engineering Proteins Serum Stability criteria Stabilization |
| title | Effects of surface functional groups on the aggregation stability of magnetite nanoparticles in biological media containing serum |
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