A pipeline for copy number variation detection based on principal component analysis

DNA copy number variation (CNV), an important structural variation, is known to be pervasive in the human genome and the determination of CNVs is essential to understanding their potential effects on the susceptibility to diseases. However, CNV detection using SNP array data is challenging due to th...

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Veröffentlicht in:	2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2011-01, Vol.2011, p.6975-6978
Hauptverfasser:	Jiayu Chen, Jingyu Liu, Boutte, D., Calhoun, V. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Arrays Bioinformatics Computer Simulation DNA DNA - analysis DNA Copy Number Variations False Positive Reactions Female Gaussian noise Genetic Predisposition to Disease Genome, Human Genomics Genotype Humans Male Normal Distribution Pipelines Polymorphism, Single Nucleotide Principal Component Analysis Reproducibility of Results Signal Processing, Computer-Assisted
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