Determining the effects of electrical stimulation on functional recovery of denervated rat gastrocnemius muscle using motor unit number estimation
The use of electrical muscle stimulation to treat denervated muscle prior to delayed reinnervation has been widely debated. There is evidence showing both positive and negative results following different protocols of electrical stimulation. In this study we investigated the role electrical stimulat...
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| Veröffentlicht in: | 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2011-01, Vol.2011, p.1977-1980 |
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| container_title | 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
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| creator | Willand, M. P. Holmes, M. Bain, J. R. Fahnestock, M. de Bruin, H. |
| description | The use of electrical muscle stimulation to treat denervated muscle prior to delayed reinnervation has been widely debated. There is evidence showing both positive and negative results following different protocols of electrical stimulation. In this study we investigated the role electrical stimulation has on muscle reinnervation following immediate and delayed nerve repair using motor unit estimation techniques. Rat gastrocnemius muscle was denervated and repaired using the peroneal nerve either immediately or following three-months with and without electrical stimulation. Motor unit counts, average motor unit sizes, and maximum compound action potentials were measured three-months following peroneal nerve repair. Motor unit counts in animals that were denervated and stimulated were significantly higher than those that were denervated and not stimulated. Both average motor unit sizes and maximum compound action potentials showed no significant differences between denervated and denervated-stimulated animals. These results provide evidence that electrical stimulation prior to delayed nerve repair increases muscle receptivity to regenerating axons and may be a worthwhile treatment for peripheral nerve injuries. |
| doi_str_mv | 10.1109/IEMBS.2011.6090557 |
| format | Article |
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Motor unit counts in animals that were denervated and stimulated were significantly higher than those that were denervated and not stimulated. Both average motor unit sizes and maximum compound action potentials showed no significant differences between denervated and denervated-stimulated animals. 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P.</creatorcontrib><creatorcontrib>Holmes, M.</creatorcontrib><creatorcontrib>Bain, J. R.</creatorcontrib><creatorcontrib>Fahnestock, M.</creatorcontrib><creatorcontrib>de Bruin, H.</creatorcontrib><title>Determining the effects of electrical stimulation on functional recovery of denervated rat gastrocnemius muscle using motor unit number estimation</title><title>2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society</title><addtitle>IEMBS</addtitle><addtitle>Conf Proc IEEE Eng Med Biol Soc</addtitle><description>The use of electrical muscle stimulation to treat denervated muscle prior to delayed reinnervation has been widely debated. There is evidence showing both positive and negative results following different protocols of electrical stimulation. In this study we investigated the role electrical stimulation has on muscle reinnervation following immediate and delayed nerve repair using motor unit estimation techniques. Rat gastrocnemius muscle was denervated and repaired using the peroneal nerve either immediately or following three-months with and without electrical stimulation. Motor unit counts, average motor unit sizes, and maximum compound action potentials were measured three-months following peroneal nerve repair. Motor unit counts in animals that were denervated and stimulated were significantly higher than those that were denervated and not stimulated. Both average motor unit sizes and maximum compound action potentials showed no significant differences between denervated and denervated-stimulated animals. These results provide evidence that electrical stimulation prior to delayed nerve repair increases muscle receptivity to regenerating axons and may be a worthwhile treatment for peripheral nerve injuries.</description><subject>Animals</subject><subject>Cell Count</subject><subject>Electric Stimulation Therapy - methods</subject><subject>Electrical stimulation</subject><subject>Electrodes</subject><subject>Maintenance engineering</subject><subject>Male</subject><subject>Motor Neurons - pathology</subject><subject>Motor Neurons - physiology</subject><subject>Muscle Denervation</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscle, Skeletal - surgery</subject><subject>Muscles</subject><subject>Nerve fibers</subject><subject>Nerve Regeneration - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Recovery of Function - physiology</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><issn>1094-687X</issn><issn>1557-170X</issn><issn>1558-4615</issn><isbn>9781424441211</isbn><isbn>1424441218</isbn><isbn>1424441226</isbn><isbn>1457715899</isbn><isbn>9781457715891</isbn><isbn>9781424441228</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNpVkd1q3DAQhdWmpUnTfYEGil7AG48s2dJNIN38QkIv2kLvjCyNNiq2HCR5Ia-RJ443fySDYA58M-cIiZDvUC4BSnV4eXr98_eSlQDLulSlEM0H8hU445wDY_VHsgdCyILXIHbIQjXyhQF8mlmpeFHL5t8uWaT0v5yrrlVVsS9klzEmeMNgj9yfYMY4-ODDmuYbpOgcmpzo6Cj2s4re6J6m7Iep19mPgc7HTcFs9UwimnGD8W67YDFg3OiMlkad6VqnHEcTcPBTosOUTI90StukYcxjpFPwmYZp6DBS3EY8Bnwjn53uEy6e-z75e3b6Z3VRXP06v1wdXxWGc5kLjYJbVgsrXGcl76qmYcwYXjqDoJ2UtgZlgWnVqcZIDkp3TEjLwBintKj2ydGT7-3UDWgNhhx1397G-R7xrh21b9-T4G_a9bhpKw5Vw6rZ4Mdbg9fNl9edBw6eBjwivuLnv6weAHAikh4</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Willand, M. 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R. ; Fahnestock, M. ; de Bruin, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-ae54d265d5fbd84b37722cc40fce1af88d619d12a9b97c8419ab258d21ccf9a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Cell Count</topic><topic>Electric Stimulation Therapy - methods</topic><topic>Electrical stimulation</topic><topic>Electrodes</topic><topic>Maintenance engineering</topic><topic>Male</topic><topic>Motor Neurons - pathology</topic><topic>Motor Neurons - physiology</topic><topic>Muscle Denervation</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscle, Skeletal - surgery</topic><topic>Muscles</topic><topic>Nerve fibers</topic><topic>Nerve Regeneration - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Recovery of Function - physiology</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Willand, M. 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P.</au><au>Holmes, M.</au><au>Bain, J. R.</au><au>Fahnestock, M.</au><au>de Bruin, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determining the effects of electrical stimulation on functional recovery of denervated rat gastrocnemius muscle using motor unit number estimation</atitle><jtitle>2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society</jtitle><stitle>IEMBS</stitle><addtitle>Conf Proc IEEE Eng Med Biol Soc</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><spage>1977</spage><epage>1980</epage><pages>1977-1980</pages><issn>1094-687X</issn><issn>1557-170X</issn><eissn>1558-4615</eissn><isbn>9781424441211</isbn><isbn>1424441218</isbn><eisbn>1424441226</eisbn><eisbn>1457715899</eisbn><eisbn>9781457715891</eisbn><eisbn>9781424441228</eisbn><abstract>The use of electrical muscle stimulation to treat denervated muscle prior to delayed reinnervation has been widely debated. There is evidence showing both positive and negative results following different protocols of electrical stimulation. In this study we investigated the role electrical stimulation has on muscle reinnervation following immediate and delayed nerve repair using motor unit estimation techniques. Rat gastrocnemius muscle was denervated and repaired using the peroneal nerve either immediately or following three-months with and without electrical stimulation. Motor unit counts, average motor unit sizes, and maximum compound action potentials were measured three-months following peroneal nerve repair. Motor unit counts in animals that were denervated and stimulated were significantly higher than those that were denervated and not stimulated. Both average motor unit sizes and maximum compound action potentials showed no significant differences between denervated and denervated-stimulated animals. 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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Animals Cell Count Electric Stimulation Therapy - methods Electrical stimulation Electrodes Maintenance engineering Male Motor Neurons - pathology Motor Neurons - physiology Muscle Denervation Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Muscle, Skeletal - surgery Muscles Nerve fibers Nerve Regeneration - physiology Rats Rats, Inbred Lew Recovery of Function - physiology Surgery Treatment Outcome |
| title | Determining the effects of electrical stimulation on functional recovery of denervated rat gastrocnemius muscle using motor unit number estimation |
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