Clinical role of hWAPL in histologic diagnosis of cervical cancer and cervical intraepithelial neoplasia: Correlation with p16INK4a expression and HPV testing
In this study, we examined the expression of hWAPL in cervical intraepithelial neoplasia (CIN) I-III and cervical squamous cell carcinoma, and investigated clinical application value of hWAPL in diagnosis of cervical disease. 90 samples were collected, and two slides from each sample were immunostai...
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| creator | Yonghong Xie Guangtao Xu Peng Shen Xiaoyan Pan Linlong Chen Ruilin Yan Fumei Zhu Yanping Zhang |
| description | In this study, we examined the expression of hWAPL in cervical intraepithelial neoplasia (CIN) I-III and cervical squamous cell carcinoma, and investigated clinical application value of hWAPL in diagnosis of cervical disease. 90 samples were collected, and two slides from each sample were immunostained using hWAPL and p16INK4a antibody. HPV-DNA testing was performed using the HC2 DNA test. The expression intensity of hWAPL in SCC group, CIN III group, CIN II group and CIN I group was obviously higher than that in normal cervix group, and the expression intensity in SCC group, CIN III group and CIN II group was higher than that in CIN I group. Based on ROC curves of hWAPL, when using ≥CIN I, ≥CIN II and ≥CIN III as cutoff for positive classification, area under the curve (AUC) was 0.815, 0.699, and 0.616, respectively. Therefore, hWAPL may be a promising candidate for diagnosis of low-grade CIN. |
| doi_str_mv | 10.1109/HHBE.2011.6028977 |
| format | Conference Proceeding |
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HPV-DNA testing was performed using the HC2 DNA test. The expression intensity of hWAPL in SCC group, CIN III group, CIN II group and CIN I group was obviously higher than that in normal cervix group, and the expression intensity in SCC group, CIN III group and CIN II group was higher than that in CIN I group. Based on ROC curves of hWAPL, when using ≥CIN I, ≥CIN II and ≥CIN III as cutoff for positive classification, area under the curve (AUC) was 0.815, 0.699, and 0.616, respectively. 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HPV-DNA testing was performed using the HC2 DNA test. The expression intensity of hWAPL in SCC group, CIN III group, CIN II group and CIN I group was obviously higher than that in normal cervix group, and the expression intensity in SCC group, CIN III group and CIN II group was higher than that in CIN I group. Based on ROC curves of hWAPL, when using ≥CIN I, ≥CIN II and ≥CIN III as cutoff for positive classification, area under the curve (AUC) was 0.815, 0.699, and 0.616, respectively. Therefore, hWAPL may be a promising candidate for diagnosis of low-grade CIN.</description><subject>Cervical cancer</subject><subject>Educational institutions</subject><subject>human papilloma virus</subject><subject>Humans</subject><subject>hWAPL gene</subject><subject>Immune system</subject><subject>immunohistochemistry</subject><subject>Neoplasms</subject><subject>p16INK4a gene</subject><subject>Proteins</subject><isbn>1612847234</isbn><isbn>9781612847238</isbn><isbn>9781612847269</isbn><isbn>1612847269</isbn><isbn>1612847250</isbn><isbn>9781612847252</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2011</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNpFUMtOwzAQNEJIQOkHIC7-gRbbTfzgViIgFRX0UMGxcu11a2TsKI54_AzfSgpF7GV2ZmfmsAidUzKmlKjLur6-GTNC6ZgTJpUQB2iohKScMlkIxtUhOv0jk-IYDXN-If1wrijnJ-irCj56owNuUwCcHN4-Txdz7CPe-tylkDbeYOv1Jqbs885goH37SRgd-x3raP81H7tWQ-O7LQTf8wipCTp7fYWr1LYQdOdTxO-9ATeUzx7uC43ho2kh591hV1YvnnAHufNxc4aOnA4ZhnscoOXtzbKqR_PHu1k1nY-8It3IMeuIJOCcImCM0ERYYRk4YUxhRWnp2jkmqOQlLbRyQtoSDCklkWtWODYZoIvfWg8Aq6b1r7r9XO0_OvkGrzttDg</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Yonghong Xie</creator><creator>Guangtao Xu</creator><creator>Peng Shen</creator><creator>Xiaoyan Pan</creator><creator>Linlong Chen</creator><creator>Ruilin Yan</creator><creator>Fumei Zhu</creator><creator>Yanping Zhang</creator><general>IEEE</general><scope>6IE</scope><scope>6IL</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIL</scope></search><sort><creationdate>201108</creationdate><title>Clinical role of hWAPL in histologic diagnosis of cervical cancer and cervical intraepithelial neoplasia: Correlation with p16INK4a expression and HPV testing</title><author>Yonghong Xie ; Guangtao Xu ; Peng Shen ; Xiaoyan Pan ; Linlong Chen ; Ruilin Yan ; Fumei Zhu ; Yanping Zhang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i90t-f2df080eff90ecc7a07d7d2ef7cc4d75d1bff27186514a9f78d5ec05808b24f23</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Cervical cancer</topic><topic>Educational institutions</topic><topic>human papilloma virus</topic><topic>Humans</topic><topic>hWAPL gene</topic><topic>Immune system</topic><topic>immunohistochemistry</topic><topic>Neoplasms</topic><topic>p16INK4a gene</topic><topic>Proteins</topic><toplevel>online_resources</toplevel><creatorcontrib>Yonghong Xie</creatorcontrib><creatorcontrib>Guangtao Xu</creatorcontrib><creatorcontrib>Peng Shen</creatorcontrib><creatorcontrib>Xiaoyan Pan</creatorcontrib><creatorcontrib>Linlong Chen</creatorcontrib><creatorcontrib>Ruilin Yan</creatorcontrib><creatorcontrib>Fumei Zhu</creatorcontrib><creatorcontrib>Yanping Zhang</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Xplore Digital Library</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Yonghong Xie</au><au>Guangtao Xu</au><au>Peng Shen</au><au>Xiaoyan Pan</au><au>Linlong Chen</au><au>Ruilin Yan</au><au>Fumei Zhu</au><au>Yanping Zhang</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Clinical role of hWAPL in histologic diagnosis of cervical cancer and cervical intraepithelial neoplasia: Correlation with p16INK4a expression and HPV testing</atitle><btitle>Proceedings 2011 International Conference on Human Health and Biomedical Engineering</btitle><stitle>HHBE</stitle><date>2011-08</date><risdate>2011</risdate><spage>936</spage><epage>940</epage><pages>936-940</pages><isbn>1612847234</isbn><isbn>9781612847238</isbn><eisbn>9781612847269</eisbn><eisbn>1612847269</eisbn><eisbn>1612847250</eisbn><eisbn>9781612847252</eisbn><abstract>In this study, we examined the expression of hWAPL in cervical intraepithelial neoplasia (CIN) I-III and cervical squamous cell carcinoma, and investigated clinical application value of hWAPL in diagnosis of cervical disease. 90 samples were collected, and two slides from each sample were immunostained using hWAPL and p16INK4a antibody. HPV-DNA testing was performed using the HC2 DNA test. The expression intensity of hWAPL in SCC group, CIN III group, CIN II group and CIN I group was obviously higher than that in normal cervix group, and the expression intensity in SCC group, CIN III group and CIN II group was higher than that in CIN I group. Based on ROC curves of hWAPL, when using ≥CIN I, ≥CIN II and ≥CIN III as cutoff for positive classification, area under the curve (AUC) was 0.815, 0.699, and 0.616, respectively. Therefore, hWAPL may be a promising candidate for diagnosis of low-grade CIN.</abstract><pub>IEEE</pub><doi>10.1109/HHBE.2011.6028977</doi><tpages>5</tpages></addata></record> |
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| subjects | Cervical cancer Educational institutions human papilloma virus Humans hWAPL gene Immune system immunohistochemistry Neoplasms p16INK4a gene Proteins |
| title | Clinical role of hWAPL in histologic diagnosis of cervical cancer and cervical intraepithelial neoplasia: Correlation with p16INK4a expression and HPV testing |
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