Lab-on-a-chip for the isolation and characterization of circulating tumor cells

A smart miniaturized system is being proposed for the isolation and characterization of circulating tumor cells (CTCs) directly from blood. Different microfluidic modules have been designed for cell enrichment and -counting, multiplex mRNA amplification as well as DNA detection. With the different m...

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Veröffentlicht in:	2010 Annual International Conference of the IEEE Engineering in Medicine and Biology 2010-01, Vol.2010, p.292-294
Hauptverfasser:	Stakenborg, Tim, Chengxu Liu, Henry, Olivier, O'Sullivan, Ciara K, Fermer, Christian, Roeser, Tina, Ritzi-Lehnert, Marion, Hauch, Sigfried, Borgen, Elin, Laddach, Nadja, Lagae, Liesbet
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Separation - instrumentation Cell Separation - methods Cytophotometry - instrumentation Cytophotometry - methods DNA DNA, Neoplasm - isolation & purification Humans Lab-On-A-Chip Devices Magnetic particles Magnetic sensors Magnetic separation Microfluidics Neoplasms - blood Neoplasms - genetics Neoplasms - pathology Neoplastic Cells, Circulating Polymerase Chain Reaction - instrumentation Polymerase Chain Reaction - methods Tumors
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Beschreibung
Zusammenfassung:	A smart miniaturized system is being proposed for the isolation and characterization of circulating tumor cells (CTCs) directly from blood. Different microfluidic modules have been designed for cell enrichment and -counting, multiplex mRNA amplification as well as DNA detection. With the different modules at hand, future effort will focus on the integration of the modules in a fully automated, single platform.
ISSN:	1094-687X 1557-170X 1558-4615
DOI:	10.1109/IEMBS.2010.5627655