Voxel-wise group analysis of DTI

Diffusion tensor MRI (DTI) is now a widely used modality to investigate the fiber tissues in vivo, especially the white matter in brain. An automatic pipeline is described in this paper to conduct a localized voxel-wise multiple-subject group comparison study of DTI. The pipeline consists of 3 steps...

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Hauptverfasser: Zhexing Liu, Hongtu Zhu, Marks, B.L., Katz, L.M., Goodlett, C.B., Gerig, G., Styner, M.
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creator Zhexing Liu
Hongtu Zhu
Marks, B.L.
Katz, L.M.
Goodlett, C.B.
Gerig, G.
Styner, M.
description Diffusion tensor MRI (DTI) is now a widely used modality to investigate the fiber tissues in vivo, especially the white matter in brain. An automatic pipeline is described in this paper to conduct a localized voxel-wise multiple-subject group comparison study of DTI. The pipeline consists of 3 steps: (1) Preprocessing, including image format converting, image quality check, eddy-current and motion artifact correction, skull stripping and tensor image estimation, (2) study-specific unbiased DTI atlas computation via affine followed by fluid nonlinear registration and warping of all individual DTI images into the common atlas space to achieve voxel-wise correspondence, (3) voxel-wise statistical analysis via heterogeneous linear regression and wild bootstrap technique for correcting for multiple comparisons. This pipeline was applied to process data from a fitness and aging study and preliminary results are presented. The results show that this fully automatic pipeline is suitable for voxel-wise group DTI analysis.
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source IEEE Electronic Library (IEL) Conference Proceedings
subjects Diffusion tensor
Diffusion tensor imaging
Group comparison
Image converters
Image quality
In vivo
Magnetic resonance imaging
Motion analysis
Motion estimation
MRI
Pipelines
Skull
Tensile stress
Voxel-wise analysis
title Voxel-wise group analysis of DTI
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