Acrylic star block copolymers as hydrophobic drug carriers
Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by atomic transfer radical polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18...
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| creator | Genc, Gozde Batigun, Aysegul Bayraktar, Oguz Altintas, Ozcan Tunca, Umit Hizal, Gurkan |
| description | Amphiphilic poly(methyl methacrylate)-b-poly(acrylic acid) (PMMA-b-PAA) copolymers with 4 and 6 arms were synthesized by atomic transfer radical polymerization (ATRP). The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium. |
| doi_str_mv | 10.1109/BIYOMUT.2009.5130339 |
| format | Conference Proceeding |
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The polymers were characterized by GPC, H-NMR and FTIR analysis. Polymer samples synthesized at various molecular weights between 18-80 kDa were investigated in terms of maximum loading capacity and critical micelle concentration by fluorescence spectroscopy. 4 arm PMMA-b-PAA (MW 30 kDa) was loaded with hydrophobic model drug indomethacin with an extremely high drug loading efficiency (22.5% drug content). Drug loaded polymer formed a stable and biodegradable complex in aqueous medium.</abstract><pub>IEEE</pub><doi>10.1109/BIYOMUT.2009.5130339</doi></addata></record> |
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| language | eng |
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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Arm Atomic measurements Biodegradable materials Drugs Fluorescence Load modeling Polymers Spectroscopy |
| title | Acrylic star block copolymers as hydrophobic drug carriers |
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