Alternans-possible mechanisms for generating it by modification of intracellular Ca/sup ++/ availability
This study describes a cellular mechanism responsible for causing mechanical and electrical alternans. It is based on a model of the regulating mechanisms of Ca/sup ++/ flow and concentrations in a myocyte, specifically those related to the sarcoplasmic reticulum (SR). The model includes regulation...
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| creator | Glukhovsky, A. Adam, D. Amitzur, G. Sideman, S. |
| description | This study describes a cellular mechanism responsible for causing mechanical and electrical alternans. It is based on a model of the regulating mechanisms of Ca/sup ++/ flow and concentrations in a myocyte, specifically those related to the sarcoplasmic reticulum (SR). The model includes regulation of the membrane SR Ca/sup ++/ channels kinetics by changes in free [Ca/sup ++/] near the openings of Ca/sup ++/ channels, by a combination of positive and negative central loops. The model predicts changes of cytoplasmatic and SR [Ca/sup ++/], including dependence on the beat intervals, either constant or during premature and delayed beats. Non-linear dependence is described between the degree of recovery of the release mechanism and the amount of Ca/sup ++/ released from the SR. This dependence is sufficient to produce mechanical and electrical alternans. The results support the basic hypothesis of control of the SR Ca/sup ++/ release channels, which may produce instabilities-e.g. alternans. |
| doi_str_mv | 10.1109/CIC.1995.482570 |
| format | Conference Proceeding |
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It is based on a model of the regulating mechanisms of Ca/sup ++/ flow and concentrations in a myocyte, specifically those related to the sarcoplasmic reticulum (SR). The model includes regulation of the membrane SR Ca/sup ++/ channels kinetics by changes in free [Ca/sup ++/] near the openings of Ca/sup ++/ channels, by a combination of positive and negative central loops. The model predicts changes of cytoplasmatic and SR [Ca/sup ++/], including dependence on the beat intervals, either constant or during premature and delayed beats. Non-linear dependence is described between the degree of recovery of the release mechanism and the amount of Ca/sup ++/ released from the SR. This dependence is sufficient to produce mechanical and electrical alternans. The results support the basic hypothesis of control of the SR Ca/sup ++/ release channels, which may produce instabilities-e.g. alternans.</description><identifier>ISBN: 9780780330535</identifier><identifier>ISBN: 0780330536</identifier><identifier>DOI: 10.1109/CIC.1995.482570</identifier><language>eng</language><publisher>IEEE</publisher><subject>Biomedical engineering ; Biomembranes ; Calcium ; Heart ; In vivo ; Kinetic theory ; Muscles ; Open loop systems ; Silver ; Strontium</subject><ispartof>Computers in Cardiology 1995, 1995, p.55-58</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/482570$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>309,310,780,784,789,790,2058,4050,4051,27925,54920</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/482570$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Glukhovsky, A.</creatorcontrib><creatorcontrib>Adam, D.</creatorcontrib><creatorcontrib>Amitzur, G.</creatorcontrib><creatorcontrib>Sideman, S.</creatorcontrib><title>Alternans-possible mechanisms for generating it by modification of intracellular Ca/sup ++/ availability</title><title>Computers in Cardiology 1995</title><addtitle>CIC</addtitle><description>This study describes a cellular mechanism responsible for causing mechanical and electrical alternans. It is based on a model of the regulating mechanisms of Ca/sup ++/ flow and concentrations in a myocyte, specifically those related to the sarcoplasmic reticulum (SR). The model includes regulation of the membrane SR Ca/sup ++/ channels kinetics by changes in free [Ca/sup ++/] near the openings of Ca/sup ++/ channels, by a combination of positive and negative central loops. The model predicts changes of cytoplasmatic and SR [Ca/sup ++/], including dependence on the beat intervals, either constant or during premature and delayed beats. Non-linear dependence is described between the degree of recovery of the release mechanism and the amount of Ca/sup ++/ released from the SR. This dependence is sufficient to produce mechanical and electrical alternans. The results support the basic hypothesis of control of the SR Ca/sup ++/ release channels, which may produce instabilities-e.g. alternans.</description><subject>Biomedical engineering</subject><subject>Biomembranes</subject><subject>Calcium</subject><subject>Heart</subject><subject>In vivo</subject><subject>Kinetic theory</subject><subject>Muscles</subject><subject>Open loop systems</subject><subject>Silver</subject><subject>Strontium</subject><isbn>9780780330535</isbn><isbn>0780330536</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>1995</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNp9jjFrwzAQhQWl0JJ6LnS6PcSW6qixx2Aa2j27Obvn5IosGZ1S8L-PIZ3zePDB-5an1KvRuTG6LprvJjd1bfNt9W53-kFl9a7SS8tS29I-qUzkVy-xtjLbj2d13rtE0aOXzRREuHMEI_Vn9CyjwBAinMhTxMT-BJygm2EMPzxwv0zBQxiAfYrYk3MXhxEaLOQywXpdAP4hO-zYcZpf1OOATij750q9HT6PzdeGiaidIo8Y5_Z2u7wrr5D-R3M</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Glukhovsky, A.</creator><creator>Adam, D.</creator><creator>Amitzur, G.</creator><creator>Sideman, S.</creator><general>IEEE</general><scope>6IE</scope><scope>6IL</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIL</scope></search><sort><creationdate>1995</creationdate><title>Alternans-possible mechanisms for generating it by modification of intracellular Ca/sup ++/ availability</title><author>Glukhovsky, A. ; Adam, D. ; Amitzur, G. ; Sideman, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-ieee_primary_4825703</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biomedical engineering</topic><topic>Biomembranes</topic><topic>Calcium</topic><topic>Heart</topic><topic>In vivo</topic><topic>Kinetic theory</topic><topic>Muscles</topic><topic>Open loop systems</topic><topic>Silver</topic><topic>Strontium</topic><toplevel>online_resources</toplevel><creatorcontrib>Glukhovsky, A.</creatorcontrib><creatorcontrib>Adam, D.</creatorcontrib><creatorcontrib>Amitzur, G.</creatorcontrib><creatorcontrib>Sideman, S.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Glukhovsky, A.</au><au>Adam, D.</au><au>Amitzur, G.</au><au>Sideman, S.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Alternans-possible mechanisms for generating it by modification of intracellular Ca/sup ++/ availability</atitle><btitle>Computers in Cardiology 1995</btitle><stitle>CIC</stitle><date>1995</date><risdate>1995</risdate><spage>55</spage><epage>58</epage><pages>55-58</pages><isbn>9780780330535</isbn><isbn>0780330536</isbn><abstract>This study describes a cellular mechanism responsible for causing mechanical and electrical alternans. It is based on a model of the regulating mechanisms of Ca/sup ++/ flow and concentrations in a myocyte, specifically those related to the sarcoplasmic reticulum (SR). The model includes regulation of the membrane SR Ca/sup ++/ channels kinetics by changes in free [Ca/sup ++/] near the openings of Ca/sup ++/ channels, by a combination of positive and negative central loops. The model predicts changes of cytoplasmatic and SR [Ca/sup ++/], including dependence on the beat intervals, either constant or during premature and delayed beats. Non-linear dependence is described between the degree of recovery of the release mechanism and the amount of Ca/sup ++/ released from the SR. This dependence is sufficient to produce mechanical and electrical alternans. The results support the basic hypothesis of control of the SR Ca/sup ++/ release channels, which may produce instabilities-e.g. alternans.</abstract><pub>IEEE</pub><doi>10.1109/CIC.1995.482570</doi></addata></record> |
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| ispartof | Computers in Cardiology 1995, 1995, p.55-58 |
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| language | eng |
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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Biomedical engineering Biomembranes Calcium Heart In vivo Kinetic theory Muscles Open loop systems Silver Strontium |
| title | Alternans-possible mechanisms for generating it by modification of intracellular Ca/sup ++/ availability |
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