Toward targeted retinal drug delivery with wireless magnetic microrobots
Retinal vein occlusion is an obstruction of blood flow due to clot formation in the retinal vasculature, and is among the most common causes of vision loss. Currently, the most promising therapy involves injection of t-PA directly into small and delicate retinal vessels. This procedure requires surg...
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| creator | Dogangil, G. Ergeneman, O. Abbott, J.J. Pane, S. Hall, H. Muntwyler, S. Nelson, B.J. |
| description | Retinal vein occlusion is an obstruction of blood flow due to clot formation in the retinal vasculature, and is among the most common causes of vision loss. Currently, the most promising therapy involves injection of t-PA directly into small and delicate retinal vessels. This procedure requires surgical skills at the limits of human performance. In this paper, targeted retinal drug delivery with wireless magnetic microrobots is proposed. We focus on four fundamental issues involved in the development of such a system: biocompatible coating of magnetic microrobots, diffusion-based drug delivery, characterization of forces needed to puncture retinal veins, and wireless magnetic force generation. We conclude that targeted drug delivery with magnetic microrobots is feasible from an engineering perspective, and the idea should now be explored for clinical efficacy. |
| doi_str_mv | 10.1109/IROS.2008.4650768 |
| format | Conference Proceeding |
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Currently, the most promising therapy involves injection of t-PA directly into small and delicate retinal vessels. This procedure requires surgical skills at the limits of human performance. In this paper, targeted retinal drug delivery with wireless magnetic microrobots is proposed. We focus on four fundamental issues involved in the development of such a system: biocompatible coating of magnetic microrobots, diffusion-based drug delivery, characterization of forces needed to puncture retinal veins, and wireless magnetic force generation. 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We conclude that targeted drug delivery with magnetic microrobots is feasible from an engineering perspective, and the idea should now be explored for clinical efficacy.</description><subject>Coatings</subject><subject>Computer aided manufacturing</subject><subject>Drugs</subject><subject>Force</subject><subject>Retina</subject><subject>Saturation magnetization</subject><subject>Veins</subject><issn>2153-0858</issn><issn>2153-0866</issn><isbn>9781424420575</isbn><isbn>1424420571</isbn><isbn>9781424420582</isbn><isbn>142442058X</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2008</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNpVkE1LAzEYhONHwVr7A8RL_sDWN9_JUYq1hUJB67lkN29qZNuV7Grpv3fFIjiHmcMzzGEIuWUwYQzc_eJ59TLhAHYitQKj7RkZO2OZ5FJyUJafkyFnShRgtb74x4y6_GPKDsj1z4wDYFZfkXHbvkMvqYTkakjm6-bgc6Cdz1vsMNCMXdr7mob8uaUB6_SF-UgPqXvrLWONbUt3frvvaxXdpSo3uSmbrr0hg-jrFsenHJHX2eN6Oi-Wq6fF9GFZJGZUV0TDRaxKy6IunQTN0LrgRVQMBGiJyqCUQWmvKxmBh-Bc2XssmTJVxawYkbvf3YSIm4-cdj4fN6eTxDft51Tw</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Dogangil, G.</creator><creator>Ergeneman, O.</creator><creator>Abbott, J.J.</creator><creator>Pane, S.</creator><creator>Hall, H.</creator><creator>Muntwyler, S.</creator><creator>Nelson, B.J.</creator><general>IEEE</general><scope>6IE</scope><scope>6IH</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIO</scope></search><sort><creationdate>200809</creationdate><title>Toward targeted retinal drug delivery with wireless magnetic microrobots</title><author>Dogangil, G. ; Ergeneman, O. ; Abbott, J.J. ; Pane, S. ; Hall, H. ; Muntwyler, S. ; Nelson, B.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i175t-f723fcb81f6b94061e89da3f5103064e57e44d56a6c4f02dd99b2ddfb157cc183</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Coatings</topic><topic>Computer aided manufacturing</topic><topic>Drugs</topic><topic>Force</topic><topic>Retina</topic><topic>Saturation magnetization</topic><topic>Veins</topic><toplevel>online_resources</toplevel><creatorcontrib>Dogangil, G.</creatorcontrib><creatorcontrib>Ergeneman, O.</creatorcontrib><creatorcontrib>Abbott, J.J.</creatorcontrib><creatorcontrib>Pane, S.</creatorcontrib><creatorcontrib>Hall, H.</creatorcontrib><creatorcontrib>Muntwyler, S.</creatorcontrib><creatorcontrib>Nelson, B.J.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan (POP) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP) 1998-present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Dogangil, G.</au><au>Ergeneman, O.</au><au>Abbott, J.J.</au><au>Pane, S.</au><au>Hall, H.</au><au>Muntwyler, S.</au><au>Nelson, B.J.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Toward targeted retinal drug delivery with wireless magnetic microrobots</atitle><btitle>2008 IEEE/RSJ International Conference on Intelligent Robots and Systems</btitle><stitle>IROS</stitle><date>2008-09</date><risdate>2008</risdate><spage>1921</spage><epage>1926</epage><pages>1921-1926</pages><issn>2153-0858</issn><eissn>2153-0866</eissn><isbn>9781424420575</isbn><isbn>1424420571</isbn><eisbn>9781424420582</eisbn><eisbn>142442058X</eisbn><abstract>Retinal vein occlusion is an obstruction of blood flow due to clot formation in the retinal vasculature, and is among the most common causes of vision loss. Currently, the most promising therapy involves injection of t-PA directly into small and delicate retinal vessels. This procedure requires surgical skills at the limits of human performance. In this paper, targeted retinal drug delivery with wireless magnetic microrobots is proposed. We focus on four fundamental issues involved in the development of such a system: biocompatible coating of magnetic microrobots, diffusion-based drug delivery, characterization of forces needed to puncture retinal veins, and wireless magnetic force generation. We conclude that targeted drug delivery with magnetic microrobots is feasible from an engineering perspective, and the idea should now be explored for clinical efficacy.</abstract><pub>IEEE</pub><doi>10.1109/IROS.2008.4650768</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 2153-0858 |
| ispartof | 2008 IEEE/RSJ International Conference on Intelligent Robots and Systems, 2008, p.1921-1926 |
| issn | 2153-0858 2153-0866 |
| language | eng |
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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Coatings Computer aided manufacturing Drugs Force Retina Saturation magnetization Veins |
| title | Toward targeted retinal drug delivery with wireless magnetic microrobots |
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