Controlled Release Drug Coatings on Flexible Neural Probes
We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biodegradable polymer. The drug eluting coating...
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| container_volume | 2007 |
| creator | Mercanzini, A. Reddy, S. Velluto, D. Colin, P. Maillard, A. Bensadoun, J.-C. Bertsch, A. Hubbell, J.A. Renaud, P. |
| description | We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biodegradable polymer. The drug eluting coating is applied to flexible polymer neural probes with platinum electrodes. The drug eluting device is implanted in one hemisphere of a rat, while a control device is implanted in the opposite hemisphere. Impedance measurements are performed to determine the effect of the drug eluting coating on the tissue reaction surrounding the probe and the electrical characteristics of the devices. Probes that are coated with drug eluting coatings show better long term impedance characteristics over control probes. These coatings can be used to increase the reliability and long term success of neural prostheses. |
| doi_str_mv | 10.1109/IEMBS.2007.4353875 |
| format | Conference Proceeding |
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The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biodegradable polymer. The drug eluting coating is applied to flexible polymer neural probes with platinum electrodes. The drug eluting device is implanted in one hemisphere of a rat, while a control device is implanted in the opposite hemisphere. Impedance measurements are performed to determine the effect of the drug eluting coating on the tissue reaction surrounding the probe and the electrical characteristics of the devices. Probes that are coated with drug eluting coatings show better long term impedance characteristics over control probes. These coatings can be used to increase the reliability and long term success of neural prostheses.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Biodegradable materials</subject><subject>Coatings</subject><subject>Delayed-Action Preparations</subject><subject>Dexamethasone - administration & dosage</subject><subject>Drug Delivery Systems</subject><subject>Drugs</subject><subject>Electric Impedance</subject><subject>Electrodes</subject><subject>Electrodes, Implanted</subject><subject>Impedance measurement</subject><subject>In vivo</subject><subject>Microelectrodes</subject><subject>Motor Cortex - physiology</subject><subject>Nanoparticles</subject><subject>Nanoparticles - administration & dosage</subject><subject>Platinum</subject><subject>Polymer films</subject><subject>Probes</subject><subject>Rats</subject><subject>Resins, Synthetic</subject><subject>Titanium</subject><issn>1094-687X</issn><issn>1557-170X</issn><issn>1558-4615</issn><isbn>9781424407873</isbn><isbn>1424407877</isbn><isbn>9781424407880</isbn><isbn>1424407885</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2007</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNpVkNtKAzEQhuMJW-q-gILkBbZONskm8c6urRbqAQ_gXUmys2Ul7ZY9gL69C62C_83w830MzBByzmDMGJir-fRh8jpOANRYcMm1kgckMkozkQgBSms4JEMmpY5FyuTRP6b4cc_AiDjV6mNAoqb5hD7c9FifkgHTfZGCDcl1Vm3augoBc_qCAW2D9LbuVjSrbFtuVg2tNnQW8Kt0AekjdrUN9LmuHDZn5KSwocFoP0fkfTZ9y-7jxdPdPLtZxCXnuo2lA4QEpc-9LowwAEXuLRQg00Kh1swalRYJ906kwJzyCQjvubTeJcr7nI_I5W7vtnNrzJfbulzb-nv5e0QvXOyEEhH_8P5r_AfZKliX</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Mercanzini, A.</creator><creator>Reddy, S.</creator><creator>Velluto, D.</creator><creator>Colin, P.</creator><creator>Maillard, A.</creator><creator>Bensadoun, J.-C.</creator><creator>Bertsch, A.</creator><creator>Hubbell, J.A.</creator><creator>Renaud, P.</creator><general>IEEE</general><scope>6IE</scope><scope>6IH</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIO</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20070101</creationdate><title>Controlled Release Drug Coatings on Flexible Neural Probes</title><author>Mercanzini, A. ; 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| identifier | ISSN: 1094-687X |
| ispartof | 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007, Vol.2007, p.6612-6615 |
| issn | 1094-687X 1557-170X 1558-4615 |
| language | eng |
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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Animals Anti-Inflammatory Agents - administration & dosage Biodegradable materials Coatings Delayed-Action Preparations Dexamethasone - administration & dosage Drug Delivery Systems Drugs Electric Impedance Electrodes Electrodes, Implanted Impedance measurement In vivo Microelectrodes Motor Cortex - physiology Nanoparticles Nanoparticles - administration & dosage Platinum Polymer films Probes Rats Resins, Synthetic Titanium |
| title | Controlled Release Drug Coatings on Flexible Neural Probes |
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