RGD nanodomains grafting onto titanium surface
Titanium alloys exhibit excellent biocompatibility and corrosion resistance in the body fluid and possess mechanical properties similar of the bones' properties. When the loss of osseous is important in osseous surgery, large biomaterials are implanted and should be accepted by the organism. Fo...
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| Veröffentlicht in: | 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2007-01, Vol.2007, p.5107-5110 |
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| container_title | 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
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| creator | Forget, G. Latxague, L. Heroguez, V. Labrugere, C. Durrieu, M.C. |
| description | Titanium alloys exhibit excellent biocompatibility and corrosion resistance in the body fluid and possess mechanical properties similar of the bones' properties. When the loss of osseous is important in osseous surgery, large biomaterials are implanted and should be accepted by the organism. For increasing the biomaterials biocompatibility, biological compounds can be linked or deposited on the material surface making them biologically active. In order to study the tissue-implant interaction and to favor osteoblast-adhesion onto titanium, our work deals with the grafting of cell-binding peptides containing the Arginine- Glycine-Aspartic acid (RGD) sequence. In the present study, we focus on the elaboration of patterned biomaterial surfaces with highly functionalized nanodomains. The strategy of RGD peptide immobilization involves first the grafting if an amino-functional organosilane (APTES). Then, each of the free amino moieties were used as an initiator core for a dendrimer-like synthesis to multiply the number of free groups available for RGD immobilization on the material surface. |
| doi_str_mv | 10.1109/IEMBS.2007.4353489 |
| format | Article |
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When the loss of osseous is important in osseous surgery, large biomaterials are implanted and should be accepted by the organism. For increasing the biomaterials biocompatibility, biological compounds can be linked or deposited on the material surface making them biologically active. In order to study the tissue-implant interaction and to favor osteoblast-adhesion onto titanium, our work deals with the grafting of cell-binding peptides containing the Arginine- Glycine-Aspartic acid (RGD) sequence. In the present study, we focus on the elaboration of patterned biomaterial surfaces with highly functionalized nanodomains. The strategy of RGD peptide immobilization involves first the grafting if an amino-functional organosilane (APTES). 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When the loss of osseous is important in osseous surgery, large biomaterials are implanted and should be accepted by the organism. For increasing the biomaterials biocompatibility, biological compounds can be linked or deposited on the material surface making them biologically active. In order to study the tissue-implant interaction and to favor osteoblast-adhesion onto titanium, our work deals with the grafting of cell-binding peptides containing the Arginine- Glycine-Aspartic acid (RGD) sequence. In the present study, we focus on the elaboration of patterned biomaterial surfaces with highly functionalized nanodomains. The strategy of RGD peptide immobilization involves first the grafting if an amino-functional organosilane (APTES). Then, each of the free amino moieties were used as an initiator core for a dendrimer-like synthesis to multiply the number of free groups available for RGD immobilization on the material surface.</description><subject>Adsorption</subject><subject>Bioengineering</subject><subject>Biomaterials</subject><subject>Bone Substitutes - chemistry</subject><subject>Bones</subject><subject>Chemical Sciences</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Corrosion</subject><subject>Crystallization - methods</subject><subject>Immune system</subject><subject>Life Sciences</subject><subject>Material chemistry</subject><subject>Materials Testing</subject><subject>Mechanical factors</subject><subject>Nanobioscience</subject><subject>Nanostructures - chemistry</subject><subject>Nanostructures - ultrastructure</subject><subject>Oligopeptides - chemistry</subject><subject>Organisms</subject><subject>Particle Size</subject><subject>Peptides</subject><subject>Protein Binding</subject><subject>Surface Properties</subject><subject>Surface resistance</subject><subject>Surgery</subject><subject>Titanium - chemistry</subject><subject>Titanium alloys</subject><issn>1094-687X</issn><issn>1557-170X</issn><issn>1558-4615</issn><isbn>9781424407873</isbn><isbn>1424407877</isbn><isbn>9781424407880</isbn><isbn>1424407885</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNpVkG1Lw0AMgM833Jj7AwrSH2DrXS_Xy32cc26DieAL-K1c19xWWdvRdoL_3oPNgfkSwvMkJGHsWvBICG7u55Pnh7co5lxHIJUENCdsaDQKiAG4RuSnrC-UwhASoc7-MS3PPeMGwgT1Z48N2_aL-5DGY7xkPYG-8M19Fr1OH4PKVnVel7ao2mDVWNcV1Sqoq64OuqKzVbErg3bXOLukK3bh7Kal4SEP2MfT5H08Cxcv0_l4tAjXIEwXGgGkcrSOMk06FrBUYCFekssTSSSzXGWxA41kdKakkE5AYkFrqXQOCHLA7vZz13aTbpuitM1PWtsinY0WqV-TmjLlXKBBjL-F12_3-naXlZQfO_7u9MLNXiiI6IgPj5W_bxdjDw</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Forget, G.</creator><creator>Latxague, L.</creator><creator>Heroguez, V.</creator><creator>Labrugere, C.</creator><creator>Durrieu, M.C.</creator><general>IEEE</general><general>Institute of Electrical and Electronics Engineers (IEEE)</general><scope>6IE</scope><scope>6IH</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIO</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-2268-8865</orcidid></search><sort><creationdate>20070101</creationdate><title>RGD nanodomains grafting onto titanium surface</title><author>Forget, G. ; Latxague, L. ; Heroguez, V. ; Labrugere, C. ; Durrieu, M.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h419t-914e5d8afeb7e7214c54a42cefd63ee3bd5b2f478e97b5313f146a477357d4843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adsorption</topic><topic>Bioengineering</topic><topic>Biomaterials</topic><topic>Bone Substitutes - chemistry</topic><topic>Bones</topic><topic>Chemical Sciences</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Corrosion</topic><topic>Crystallization - methods</topic><topic>Immune system</topic><topic>Life Sciences</topic><topic>Material chemistry</topic><topic>Materials Testing</topic><topic>Mechanical factors</topic><topic>Nanobioscience</topic><topic>Nanostructures - chemistry</topic><topic>Nanostructures - ultrastructure</topic><topic>Oligopeptides - chemistry</topic><topic>Organisms</topic><topic>Particle Size</topic><topic>Peptides</topic><topic>Protein Binding</topic><topic>Surface Properties</topic><topic>Surface resistance</topic><topic>Surgery</topic><topic>Titanium - chemistry</topic><topic>Titanium alloys</topic><toplevel>online_resources</toplevel><creatorcontrib>Forget, G.</creatorcontrib><creatorcontrib>Latxague, L.</creatorcontrib><creatorcontrib>Heroguez, V.</creatorcontrib><creatorcontrib>Labrugere, C.</creatorcontrib><creatorcontrib>Durrieu, M.C.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan (POP) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP) 1998-present</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Forget, G.</au><au>Latxague, L.</au><au>Heroguez, V.</au><au>Labrugere, C.</au><au>Durrieu, M.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RGD nanodomains grafting onto titanium surface</atitle><jtitle>2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society</jtitle><stitle>IEMBS</stitle><addtitle>Conf Proc IEEE Eng Med Biol Soc</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>2007</volume><spage>5107</spage><epage>5110</epage><pages>5107-5110</pages><issn>1094-687X</issn><issn>1557-170X</issn><eissn>1558-4615</eissn><isbn>9781424407873</isbn><isbn>1424407877</isbn><eisbn>9781424407880</eisbn><eisbn>1424407885</eisbn><abstract>Titanium alloys exhibit excellent biocompatibility and corrosion resistance in the body fluid and possess mechanical properties similar of the bones' properties. When the loss of osseous is important in osseous surgery, large biomaterials are implanted and should be accepted by the organism. For increasing the biomaterials biocompatibility, biological compounds can be linked or deposited on the material surface making them biologically active. In order to study the tissue-implant interaction and to favor osteoblast-adhesion onto titanium, our work deals with the grafting of cell-binding peptides containing the Arginine- Glycine-Aspartic acid (RGD) sequence. In the present study, we focus on the elaboration of patterned biomaterial surfaces with highly functionalized nanodomains. The strategy of RGD peptide immobilization involves first the grafting if an amino-functional organosilane (APTES). 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| subjects | Adsorption Bioengineering Biomaterials Bone Substitutes - chemistry Bones Chemical Sciences Coated Materials, Biocompatible - chemistry Corrosion Crystallization - methods Immune system Life Sciences Material chemistry Materials Testing Mechanical factors Nanobioscience Nanostructures - chemistry Nanostructures - ultrastructure Oligopeptides - chemistry Organisms Particle Size Peptides Protein Binding Surface Properties Surface resistance Surgery Titanium - chemistry Titanium alloys |
| title | RGD nanodomains grafting onto titanium surface |
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