Computer Based Optimization of Biventricular Pacing According to the Left Ventricular 17 Myocardial Segments
Cardiac resynchronization therapy (CRT) has shown to improve hemodynamics and clinical symptoms of congestive heart failure. The present article investigates an automated non-invasive strategy based on a computer model of the heart to optimize biventricular pacing as a CRT with respect to electrode...
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| creator | Miri, R. Reumann, M. Keller, D. Farina, D. Dossel, O. |
| description | Cardiac resynchronization therapy (CRT) has shown to improve hemodynamics and clinical symptoms of congestive heart failure. The present article investigates an automated non-invasive strategy based on a computer model of the heart to optimize biventricular pacing as a CRT with respect to electrode positioning and timing delays. Accurate simulations of the electrical activities of the heart require suitable anatomical and electrophysiological models. The anatomical model used in this work, is based on segmented MR data of a patient in which a variety of tissue classes for left ventricle are considered based on AHA standard in accordance with fiber orientation. The excitation propagation is simulated with the ten Tusscher et al. electrophysiological cell model using an adaptive cellular automaton. The simulated activation times of different myocytes in the healthy and diseased heart model are compared in terms of root mean square error (E RMS ). The results of our investigation demonstrate that the efficacy of biventricular pacing can greatly be improved by proper electrode positioning and optimized A-V and V-V delay. |
| doi_str_mv | 10.1109/IEMBS.2007.4352565 |
| format | Conference Proceeding |
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The present article investigates an automated non-invasive strategy based on a computer model of the heart to optimize biventricular pacing as a CRT with respect to electrode positioning and timing delays. Accurate simulations of the electrical activities of the heart require suitable anatomical and electrophysiological models. The anatomical model used in this work, is based on segmented MR data of a patient in which a variety of tissue classes for left ventricle are considered based on AHA standard in accordance with fiber orientation. The excitation propagation is simulated with the ten Tusscher et al. electrophysiological cell model using an adaptive cellular automaton. The simulated activation times of different myocytes in the healthy and diseased heart model are compared in terms of root mean square error (E RMS ). 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The present article investigates an automated non-invasive strategy based on a computer model of the heart to optimize biventricular pacing as a CRT with respect to electrode positioning and timing delays. Accurate simulations of the electrical activities of the heart require suitable anatomical and electrophysiological models. The anatomical model used in this work, is based on segmented MR data of a patient in which a variety of tissue classes for left ventricle are considered based on AHA standard in accordance with fiber orientation. The excitation propagation is simulated with the ten Tusscher et al. electrophysiological cell model using an adaptive cellular automaton. The simulated activation times of different myocytes in the healthy and diseased heart model are compared in terms of root mean square error (E RMS ). The results of our investigation demonstrate that the efficacy of biventricular pacing can greatly be improved by proper electrode positioning and optimized A-V and V-V delay.</description><subject>Automata</subject><subject>Cardiac Pacing, Artificial - methods</subject><subject>Cathode ray tubes</subject><subject>Computational modeling</subject><subject>Computer Simulation</subject><subject>Delay</subject><subject>Electrodes</subject><subject>Heart</subject><subject>Heart Conduction System - physiopathology</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - prevention & control</subject><subject>Heart Ventricles - physiopathology</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Medical treatment</subject><subject>Models, Cardiovascular</subject><subject>Myocardium</subject><subject>Prognosis</subject><subject>Therapy, Computer-Assisted - methods</subject><subject>Timing</subject><subject>Treatment Outcome</subject><subject>Ventricular Dysfunction, Left - complications</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Dysfunction, Left - prevention & control</subject><issn>1094-687X</issn><issn>1557-170X</issn><issn>1558-4615</issn><isbn>9781424407873</isbn><isbn>1424407877</isbn><isbn>9781424407880</isbn><isbn>1424407885</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2007</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNpVkF1LwzAUhuMXbsz9AQXJH-g8-WrSy21MHWxMmIp3I03SGWnX0maD-eutbIqem3PgeTjwvghdExgQAsnddDIfLQcUQA44E1TE4gT1E6kIp5yDVApOUZcIoSIeE3H2j0l23jJIeBQr-dZB_ab5gHZY0mJ1iTpEAVDKSBfl47KotsHVeKQbZ_GiCr7wnzr4coPLDI_8zm1C7c021zV-0sZv1nhoTFnb7yuUOLw7PHNZwK9_RCLxfF8a3Vo6x0u3LlrYXKGLTOeN6x93D73cT57Hj9Fs8TAdD2eRZ0yFyCqZJkyllpuY2JRIailNY-DA2kyxdho0zbJEGaBgmVKCJkZQZbV2TnDLeuj28LfapoWzq6r2ha73q5_YrXBzELxz7hcfe2ZfzgFqcQ</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Miri, R.</creator><creator>Reumann, M.</creator><creator>Keller, D.</creator><creator>Farina, D.</creator><creator>Dossel, O.</creator><general>IEEE</general><scope>6IE</scope><scope>6IH</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIO</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20070101</creationdate><title>Computer Based Optimization of Biventricular Pacing According to the Left Ventricular 17 Myocardial Segments</title><author>Miri, R. ; Reumann, M. ; Keller, D. ; Farina, D. ; Dossel, O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i338t-d87b938bd4c61db172d22b604030946aea0a2ff98c020d388529c528daaee54d3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Automata</topic><topic>Cardiac Pacing, Artificial - methods</topic><topic>Cathode ray tubes</topic><topic>Computational modeling</topic><topic>Computer Simulation</topic><topic>Delay</topic><topic>Electrodes</topic><topic>Heart</topic><topic>Heart Conduction System - physiopathology</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - prevention & control</topic><topic>Heart Ventricles - physiopathology</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Medical treatment</topic><topic>Models, Cardiovascular</topic><topic>Myocardium</topic><topic>Prognosis</topic><topic>Therapy, Computer-Assisted - methods</topic><topic>Timing</topic><topic>Treatment Outcome</topic><topic>Ventricular Dysfunction, Left - complications</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Dysfunction, Left - prevention & control</topic><toplevel>online_resources</toplevel><creatorcontrib>Miri, R.</creatorcontrib><creatorcontrib>Reumann, M.</creatorcontrib><creatorcontrib>Keller, D.</creatorcontrib><creatorcontrib>Farina, D.</creatorcontrib><creatorcontrib>Dossel, O.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan (POP) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Xplore (Online service)</collection><collection>IEEE Proceedings Order Plans (POP) 1998-present</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Miri, R.</au><au>Reumann, M.</au><au>Keller, D.</au><au>Farina, D.</au><au>Dossel, O.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Computer Based Optimization of Biventricular Pacing According to the Left Ventricular 17 Myocardial Segments</atitle><btitle>2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society</btitle><stitle>IEMBS</stitle><addtitle>Conf Proc IEEE Eng Med Biol Soc</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>2007</volume><spage>1418</spage><epage>1421</epage><pages>1418-1421</pages><issn>1094-687X</issn><issn>1557-170X</issn><eissn>1558-4615</eissn><isbn>9781424407873</isbn><isbn>1424407877</isbn><eisbn>9781424407880</eisbn><eisbn>1424407885</eisbn><abstract>Cardiac resynchronization therapy (CRT) has shown to improve hemodynamics and clinical symptoms of congestive heart failure. The present article investigates an automated non-invasive strategy based on a computer model of the heart to optimize biventricular pacing as a CRT with respect to electrode positioning and timing delays. Accurate simulations of the electrical activities of the heart require suitable anatomical and electrophysiological models. The anatomical model used in this work, is based on segmented MR data of a patient in which a variety of tissue classes for left ventricle are considered based on AHA standard in accordance with fiber orientation. The excitation propagation is simulated with the ten Tusscher et al. electrophysiological cell model using an adaptive cellular automaton. The simulated activation times of different myocytes in the healthy and diseased heart model are compared in terms of root mean square error (E RMS ). 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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Automata Cardiac Pacing, Artificial - methods Cathode ray tubes Computational modeling Computer Simulation Delay Electrodes Heart Heart Conduction System - physiopathology Heart Failure - complications Heart Failure - physiopathology Heart Failure - prevention & control Heart Ventricles - physiopathology Hemodynamics Humans Medical treatment Models, Cardiovascular Myocardium Prognosis Therapy, Computer-Assisted - methods Timing Treatment Outcome Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - prevention & control |
| title | Computer Based Optimization of Biventricular Pacing According to the Left Ventricular 17 Myocardial Segments |
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