Meniscus-Assisted Magnetic Bead Trapping on Ewod-Based Digital Microfluidics for Specific Protein Localization

Meniscus-Assisted Magnetic Bead Trapping on Ewod-Based Digital Microfluidics for Specific Protein Localization

This paper presents a technique to localize specific proteins utilizing magnetic beads (MBs) in digital (droplet) microfluidics, operated by electrowetting-on-dielectric (EWOD). We identify the fundamental differences between digital and continuous microfluidics in utilizing magnetic beads, and demo...

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Hauptverfasser: Shah, G.J., Pierstorff, E., Dean Ho, Chang-Jin Kim
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Aerospace engineering
Force sensors
Magnetic devices
Magnetic fields
Magnetic flux
Magnetic forces
Magnetic separation
Microfluidics
Permanent magnets
Protein engineering
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Beschreibung
Zusammenfassung:This paper presents a technique to localize specific proteins utilizing magnetic beads (MBs) in digital (droplet) microfluidics, operated by electrowetting-on-dielectric (EWOD). We identify the fundamental differences between digital and continuous microfluidics in utilizing magnetic beads, and demonstrate the technique on an EWOD device. We also show specific, localized concentration of a target protein over antibody- conjugated MBs ("MB-Abs") as proof of concept.
ISSN:2159-547X
DOI:10.1109/SENSOR.2007.4300228