Tracking the 3-Base Periodicity of Protein-Coding Regions by the Nonlinear Tracking-Differentiator

Tracking the 3-Base Periodicity of Protein-Coding Regions by the Nonlinear Tracking-Differentiator

In this paper, a new algorithm to predict protein-coding regions by tracking the 3-base periodicity of DNA sequences is presented. A nonlinear tracking-differentiator (TD) is explored to generate smooth approximation of the trajectories of the 3-periodicity of DNA sequences and compute the derivativ...

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Bibliographische Detailangaben
Hauptverfasser: Changchuan Yin, Dongchul Yoo, Yau, S.S.-T.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Bioinformatics
Computer science
DNA
Genomics
Mathematics
Prediction algorithms
Proteins
Sequences
Statistics
Trajectory
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Beschreibung
Zusammenfassung:In this paper, a new algorithm to predict protein-coding regions by tracking the 3-base periodicity of DNA sequences is presented. A nonlinear tracking-differentiator (TD) is explored to generate smooth approximation of the trajectories of the 3-periodicity of DNA sequences and compute the derivatives, based on which protein-coding and non-coding regions can be identified. Case studies demonstrate that the nonlinear TD is an effective method to improve the accuracy of the gene finding algorithm
ISSN:0191-2216
DOI:10.1109/CDC.2006.377109