Predictions of the ball and chain model of channel inactivation
Voltage gated ion channels activate in response to step changes in voltage but slowly inactivate even though the voltage is maintained. It has been proposed that part of the channel forms a ball tethered to a chain and inactivation occurs when this ball binds to a site blocking the pore of the chann...
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| creator | Liebovitch, L.S. Selector, L.Y. |
| description | Voltage gated ion channels activate in response to step changes in voltage but slowly inactivate even though the voltage is maintained. It has been proposed that part of the channel forms a ball tethered to a chain and inactivation occurs when this ball binds to a site blocking the pore of the channel. The authors derived the statistical properties of this model so that it can be quantitatively tested by single-channel experiments on mutant channels with chains of different lengths. The model predicts that the distribution of the times for the ball to reach the binding site is a single exponential, with a rate constant that is inversely proportional to the square of the length of the chain.< > |
| doi_str_mv | 10.1109/NEBC.1992.285938 |
| format | Conference Proceeding |
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It has been proposed that part of the channel forms a ball tethered to a chain and inactivation occurs when this ball binds to a site blocking the pore of the channel. The authors derived the statistical properties of this model so that it can be quantitatively tested by single-channel experiments on mutant channels with chains of different lengths. The model predicts that the distribution of the times for the ball to reach the binding site is a single exponential, with a rate constant that is inversely proportional to the square of the length of the chain.< ></description><identifier>ISBN: 9780780309029</identifier><identifier>ISBN: 0780309022</identifier><identifier>DOI: 10.1109/NEBC.1992.285938</identifier><language>eng</language><publisher>IEEE</publisher><subject>Biomembranes ; Cells (biology) ; Lipidomics ; Numerical simulation ; Predictive models ; Probability density function ; Proteins ; Shape ; Testing ; Voltage</subject><ispartof>[1992] Proceedings of the Eighteenth IEEE Annual Northeast Bioengineering Conference, 1992, p.1-2</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/285938$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>309,310,776,780,785,786,2051,4035,4036,27904,54898</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/285938$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Liebovitch, L.S.</creatorcontrib><creatorcontrib>Selector, L.Y.</creatorcontrib><title>Predictions of the ball and chain model of channel inactivation</title><title>[1992] Proceedings of the Eighteenth IEEE Annual Northeast Bioengineering Conference</title><addtitle>NEBC</addtitle><description>Voltage gated ion channels activate in response to step changes in voltage but slowly inactivate even though the voltage is maintained. It has been proposed that part of the channel forms a ball tethered to a chain and inactivation occurs when this ball binds to a site blocking the pore of the channel. The authors derived the statistical properties of this model so that it can be quantitatively tested by single-channel experiments on mutant channels with chains of different lengths. The model predicts that the distribution of the times for the ball to reach the binding site is a single exponential, with a rate constant that is inversely proportional to the square of the length of the chain.< ></description><subject>Biomembranes</subject><subject>Cells (biology)</subject><subject>Lipidomics</subject><subject>Numerical simulation</subject><subject>Predictive models</subject><subject>Probability density function</subject><subject>Proteins</subject><subject>Shape</subject><subject>Testing</subject><subject>Voltage</subject><isbn>9780780309029</isbn><isbn>0780309022</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>1992</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNotT11LxDAQDIignH0Xn_IHWjcfbZMn0XJ-wKH3cD4f22TDRXqptEXw35vjHBZ2lmGGHcZuBVRCgL1_Xz91lbBWVtLUVpkLVtjWQB4FFqS9YsU8f0GGka1V4po9bCfy0S1xTDMfA18OxHscBo7Jc3fAmPhx9DSctHymlGlMmA0_eDLdsMuAw0zF_16xz-f1rnstNx8vb93jpoyi1UuJ0CidHwIvhTZOeQON87WrAyokkpKoca3DAMHpnghbhOCdAF0b2zdGrdjdOTcS0f57ikecfvfnluoPnTxIDw</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Liebovitch, L.S.</creator><creator>Selector, L.Y.</creator><general>IEEE</general><scope>6IE</scope><scope>6IL</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIL</scope></search><sort><creationdate>1992</creationdate><title>Predictions of the ball and chain model of channel inactivation</title><author>Liebovitch, L.S. ; Selector, L.Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i174t-a06349380d2148c3d806cd5c5fa3aee22ee6c7caf0fc4beea7a0fdc104589b683</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biomembranes</topic><topic>Cells (biology)</topic><topic>Lipidomics</topic><topic>Numerical simulation</topic><topic>Predictive models</topic><topic>Probability density function</topic><topic>Proteins</topic><topic>Shape</topic><topic>Testing</topic><topic>Voltage</topic><toplevel>online_resources</toplevel><creatorcontrib>Liebovitch, L.S.</creatorcontrib><creatorcontrib>Selector, L.Y.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Liebovitch, L.S.</au><au>Selector, L.Y.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Predictions of the ball and chain model of channel inactivation</atitle><btitle>[1992] Proceedings of the Eighteenth IEEE Annual Northeast Bioengineering Conference</btitle><stitle>NEBC</stitle><date>1992</date><risdate>1992</risdate><spage>1</spage><epage>2</epage><pages>1-2</pages><isbn>9780780309029</isbn><isbn>0780309022</isbn><abstract>Voltage gated ion channels activate in response to step changes in voltage but slowly inactivate even though the voltage is maintained. It has been proposed that part of the channel forms a ball tethered to a chain and inactivation occurs when this ball binds to a site blocking the pore of the channel. The authors derived the statistical properties of this model so that it can be quantitatively tested by single-channel experiments on mutant channels with chains of different lengths. The model predicts that the distribution of the times for the ball to reach the binding site is a single exponential, with a rate constant that is inversely proportional to the square of the length of the chain.< ></abstract><pub>IEEE</pub><doi>10.1109/NEBC.1992.285938</doi><tpages>2</tpages></addata></record> |
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| identifier | ISBN: 9780780309029 |
| ispartof | [1992] Proceedings of the Eighteenth IEEE Annual Northeast Bioengineering Conference, 1992, p.1-2 |
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| language | eng |
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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Biomembranes Cells (biology) Lipidomics Numerical simulation Predictive models Probability density function Proteins Shape Testing Voltage |
| title | Predictions of the ball and chain model of channel inactivation |
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