Locally targeted drug delivery to magnetic stents for therapeutic applications

The ability to safely and effectively deliver high dosages of drugs to specific sites in the human body is fundamental to the advancement of drug delivery research. Drugs with proven effectiveness under in vitro investigation often reach a major roadblock under in vivo testing due to a lack of an ef...

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Hauptverfasser:	Forbes, Z.G., Halverson, D.S., Fridman, G., Yellen, B.B., Chorny, M., Friedman, G., Barbee, K.A.
Format:	Tagungsbericht
Sprache:	eng
Schlagworte:	Application software Biomedical engineering Coils Drug delivery Humans Injuries Magnetic fields magnetic targeting Medical treatment Muscles stent Targeted drug delivery
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creator	Forbes, Z.G. Halverson, D.S. Fridman, G. Yellen, B.B. Chorny, M. Friedman, G. Barbee, K.A.
description	The ability to safely and effectively deliver high dosages of drugs to specific sites in the human body is fundamental to the advancement of drug delivery research. Drugs with proven effectiveness under in vitro investigation often reach a major roadblock under in vivo testing due to a lack of an effective delivery strategy. In addition, many clinical scenarios require delivery of agents that are therapeutic at the desired delivery point, but otherwise systemically toxic. This paper proposes a method for targeted drug delivery by applying high magnetic field gradients within the body to an injected superparamagnetic colloidal fluid carrying a drug, without relying on magnetic coils held external to the body to provide the force. The experimental flow model presented gives insight into the use of magnetic carriers for site-specific delivery of therapeutic agents
doi_str_mv	10.1109/ISSMD.2004.1689549
format	Conference Proceeding
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identifier	ISBN: 9780780386129
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source	IEEE Electronic Library (IEL) Conference Proceedings
subjects	Application software Biomedical engineering Coils Drug delivery Humans Injuries Magnetic fields magnetic targeting Medical treatment Muscles stent Targeted drug delivery
title	Locally targeted drug delivery to magnetic stents for therapeutic applications
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