Genetically-engineered whole-cell bioreporters on integrated circuits for very low-level chemical sensing
We report a biosensor using genetically-engineered whole-cell bioreporters on integrated circuit for low-level chemical sensing. The bioluminescent bioreporters are bacteria that can be genetically altered to achieve bioluminescence when in contact with a targeted substance. The bioreporters are pla...
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| creator | Islam, S.K. Weathers, B. Terry, S.C. Zhang, M. Blalock, B. Caylor, S. Ripp, S. Sayler, G.S. |
| description | We report a biosensor using genetically-engineered whole-cell bioreporters on integrated circuit for low-level chemical sensing. The bioluminescent bioreporters are bacteria that can be genetically altered to achieve bioluminescence when in contact with a targeted substance. The bioreporters are placed on a microluminometer. The microluminometer includes integrated photodetector and signal processor and is realized on a standard CMOS process. The bioluminescent bioreporter integrated circuit (BBIC) can detect luminescence from as few as 5000 fully induced pseudomonas fluorescene 5RL bacteria cell. |
| doi_str_mv | 10.1109/ESSDER.2005.1546657 |
| format | Conference Proceeding |
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| ispartof | Proceedings of 35th European Solid-State Device Research Conference, 2005. ESSDERC 2005, 2005, p.351-354 |
| issn | 1930-8876 |
| language | eng |
| recordid | cdi_ieee_primary_1546657 |
| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Bioluminescence Chemical technology Fluorescence Microorganisms Organisms Pollution measurement Proteins Signal analysis Signal generators Soil |
| title | Genetically-engineered whole-cell bioreporters on integrated circuits for very low-level chemical sensing |
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