Beta-adrenergic receptor blockade attenuates the electronic uncoupling induced by coronary artery occlusion

Beta-adrenergic receptor blockade attenuates the electronic uncoupling induced by coronary artery occlusion

Nine dogs (n=9) with healed anterolateral (L1Da) infarction, were chronicully instrumented for myocardial electrical impedance (MEI) measurements, and subjected to brief (2min) LCXa occlusions with (BETA) and without (CTRL) beta-adrenergic receptor blockade. Scar tissue (LADu) had significantly lowe...

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Hauptverfasser: del Rio, C.L., Dzwonczyk, R., McConnell, P.I., Clymer, B.D., Howie, M.B., Billman, G.E.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Analysis of variance
Animals
Arterial occlusion
Arteries
Dogs
Impedance
Ischemic pain
Myocardium
Protection
Surgery
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Dzwonczyk, R.
McConnell, P.I.
Clymer, B.D.
Howie, M.B.
Billman, G.E.
description Nine dogs (n=9) with healed anterolateral (L1Da) infarction, were chronicully instrumented for myocardial electrical impedance (MEI) measurements, and subjected to brief (2min) LCXa occlusions with (BETA) and without (CTRL) beta-adrenergic receptor blockade. Scar tissue (LADu) had significantly lower ME1 (373.5H8.8R) than normal (LCXa) myocardium (CTRL: 548.899.012, BETA: 532.2G4.1Sl). MEI increased signQicantly after 2min LCXu occlusion (CTRL and BETA). However, beta-adrenergic receplur blockade significantly attenuated the magnitude of such increase. In control conditions (CTRL) MEi increased 4..5H.8% (21.3&7.a), while wirh beta-blockade if changed only by 3.441.8% (15.66.751). In a I-D cable model of propagating action potentials (Luo-Rudy formulation), such reduction of the ischemic electronic uncoupling prevented conduction block ut the ischemic/scar interface.
doi_str_mv 10.1109/CIC.2004.1442958
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Scar tissue (LADu) had significantly lower ME1 (373.5H8.8R) than normal (LCXa) myocardium (CTRL: 548.899.012, BETA: 532.2G4.1Sl). MEI increased signQicantly after 2min LCXu occlusion (CTRL and BETA). However, beta-adrenergic receplur blockade significantly attenuated the magnitude of such increase. In control conditions (CTRL) MEi increased 4..5H.8% (21.3&amp;7.a), while wirh beta-blockade if changed only by 3.441.8% (15.66.751). 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subjects Analysis of variance
Animals
Arterial occlusion
Arteries
Dogs
Impedance
Ischemic pain
Myocardium
Protection
Surgery
title Beta-adrenergic receptor blockade attenuates the electronic uncoupling induced by coronary artery occlusion
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