Estimation of ethanol infusion profile to produce specified BrAC time course using physiologically-based pharmacokinetic (PBPK) models

A procedure for estimating the alcohol infusion profile required to produce a specific breath alcohol concentration (BrAC) time course using a PBPK model is described. Model parameter values are predicted from linear relationships to readily measurable physical characteristics or morphometrics. An a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Plawecki, M.H., DeCarlo, R.A., Ramchandani, V.A., O'Connor, S.
Format:	Tagungsbericht
Sprache:	eng
Schlagworte:	Absorption alcohol Alcoholic beverages Alcoholism Biomedical engineering Biomedical measurements breath alcohol concentration time course Clamps Drugs Ethanol History least squares approximation morphometrics optimization parameter identification pharmacokinetics physiologically-based pharmacokinetic model Physiology
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A procedure for estimating the alcohol infusion profile required to produce a specific breath alcohol concentration (BrAC) time course using a PBPK model is described. Model parameter values are predicted from linear relationships to readily measurable physical characteristics or morphometrics. An algorithm to optimize this transformation, based upon recorded clinical experimental data, is provided. A substantial improvement in all error statistics, in relation to the original transform was obtained.
DOI:	10.1109/IEMBS.2004.1403274