Extracting ventricular and atrial compliance and mitral impedance from Doppler inflow velocity and chamber pressures: inversion of a mitral flow model
A lumped parameter mathematical model of left ventricular filling applicable to analysis of Doppler mitral velocity inflow patterns has been developed. As originally formulated, the model utilizes user-provided chamber compliance and mitral impedance parameters and returns the time course of chamber...
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creator | Thomas, J.D. Newell, J.B. Flachskampf, F.A. Chen, C. Liu, C.-M. Weyman, A.E. |
description | A lumped parameter mathematical model of left ventricular filling applicable to analysis of Doppler mitral velocity inflow patterns has been developed. As originally formulated, the model utilizes user-provided chamber compliance and mitral impedance parameters and returns the time course of chamber pressure and mitral velocity and flow. The authors describe their initial experience with an algorithm to invert the model, i.e. to analyze observed pressure and flow data and extract the compliance and impedance parameters underlying the observed curves. This algorithm repeatedly solves the forward model, adjusting the physiologic parameters using the Marquardt method until the fit to the observed pressure and flow data is optimized. This algorithm was tested against computer-generated data with up to 10% Gaussian noise. It has also been validated with data from an in vitro analog of the left heart and from a canine model of mitral stenosis. Other possible inversion schemes, such as those which utilize only noninvasive data, are also discussed.< > |
doi_str_mv | 10.1109/CIC.1989.130467 |
format | Conference Proceeding |
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As originally formulated, the model utilizes user-provided chamber compliance and mitral impedance parameters and returns the time course of chamber pressure and mitral velocity and flow. The authors describe their initial experience with an algorithm to invert the model, i.e. to analyze observed pressure and flow data and extract the compliance and impedance parameters underlying the observed curves. This algorithm repeatedly solves the forward model, adjusting the physiologic parameters using the Marquardt method until the fit to the observed pressure and flow data is optimized. This algorithm was tested against computer-generated data with up to 10% Gaussian noise. It has also been validated with data from an in vitro analog of the left heart and from a canine model of mitral stenosis. Other possible inversion schemes, such as those which utilize only noninvasive data, are also discussed.< ></description><identifier>ISBN: 0818621141</identifier><identifier>ISBN: 9780818621147</identifier><identifier>DOI: 10.1109/CIC.1989.130467</identifier><language>eng</language><publisher>IEEE Comput. Soc. Press</publisher><subject>Algorithm design and analysis ; Data mining ; Filling ; Gaussian noise ; Impedance ; In vitro ; Mathematical model ; Optimization methods ; Pattern analysis ; Testing</subject><ispartof>[1989] Proceedings. 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Computers in Cardiology</title><addtitle>CIC</addtitle><description>A lumped parameter mathematical model of left ventricular filling applicable to analysis of Doppler mitral velocity inflow patterns has been developed. As originally formulated, the model utilizes user-provided chamber compliance and mitral impedance parameters and returns the time course of chamber pressure and mitral velocity and flow. The authors describe their initial experience with an algorithm to invert the model, i.e. to analyze observed pressure and flow data and extract the compliance and impedance parameters underlying the observed curves. This algorithm repeatedly solves the forward model, adjusting the physiologic parameters using the Marquardt method until the fit to the observed pressure and flow data is optimized. This algorithm was tested against computer-generated data with up to 10% Gaussian noise. It has also been validated with data from an in vitro analog of the left heart and from a canine model of mitral stenosis. Other possible inversion schemes, such as those which utilize only noninvasive data, are also discussed.< ></description><subject>Algorithm design and analysis</subject><subject>Data mining</subject><subject>Filling</subject><subject>Gaussian noise</subject><subject>Impedance</subject><subject>In vitro</subject><subject>Mathematical model</subject><subject>Optimization methods</subject><subject>Pattern analysis</subject><subject>Testing</subject><isbn>0818621141</isbn><isbn>9780818621147</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>1989</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNo1UMtOwzAQtISQePWMxMk_0GIn9YsbCgUqVeLSe-XYazCy48hJC_0RvhcrhT3samZn5jAI3VKyoJSo-2bdLKiSakFrsuTiDF0RSSWvKF3SCzQbhk9ShjFZ8CX6WX2PWZvRd-_4AN2YvdkHnbHuLNYF6YBNin3wujMwsdEXQ8A-9mAn0uUU8VPq-wAZ-86F9FWiQjJ-PE4O86FjW359hmHYl_VQZAfIg08dTg7r_8zJGpOFcIPOnQ4DzP7uNdo-r7bN63zz9rJuHjdzL8U4h9YxolvVEiE4r1ogtlYctAHKBHNM1ES0TvLCVbKyVpGlqhwUsWXOVLy-RnenWA8Auz77qPNxdyqu_gVPmGeX</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Thomas, J.D.</creator><creator>Newell, J.B.</creator><creator>Flachskampf, F.A.</creator><creator>Chen, C.</creator><creator>Liu, C.-M.</creator><creator>Weyman, A.E.</creator><general>IEEE Comput. Soc. Press</general><scope>6IE</scope><scope>6IL</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIL</scope></search><sort><creationdate>1989</creationdate><title>Extracting ventricular and atrial compliance and mitral impedance from Doppler inflow velocity and chamber pressures: inversion of a mitral flow model</title><author>Thomas, J.D. ; Newell, J.B. ; Flachskampf, F.A. ; Chen, C. ; Liu, C.-M. ; Weyman, A.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i87t-ebf50ab9b077662be0d396eace1575f57307bf8696e282dd90492fe776d5fc263</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Algorithm design and analysis</topic><topic>Data mining</topic><topic>Filling</topic><topic>Gaussian noise</topic><topic>Impedance</topic><topic>In vitro</topic><topic>Mathematical model</topic><topic>Optimization methods</topic><topic>Pattern analysis</topic><topic>Testing</topic><toplevel>online_resources</toplevel><creatorcontrib>Thomas, J.D.</creatorcontrib><creatorcontrib>Newell, J.B.</creatorcontrib><creatorcontrib>Flachskampf, F.A.</creatorcontrib><creatorcontrib>Chen, C.</creatorcontrib><creatorcontrib>Liu, C.-M.</creatorcontrib><creatorcontrib>Weyman, A.E.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Thomas, J.D.</au><au>Newell, J.B.</au><au>Flachskampf, F.A.</au><au>Chen, C.</au><au>Liu, C.-M.</au><au>Weyman, A.E.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Extracting ventricular and atrial compliance and mitral impedance from Doppler inflow velocity and chamber pressures: inversion of a mitral flow model</atitle><btitle>[1989] Proceedings. Computers in Cardiology</btitle><stitle>CIC</stitle><date>1989</date><risdate>1989</risdate><spage>9</spage><epage>14</epage><pages>9-14</pages><isbn>0818621141</isbn><isbn>9780818621147</isbn><abstract>A lumped parameter mathematical model of left ventricular filling applicable to analysis of Doppler mitral velocity inflow patterns has been developed. As originally formulated, the model utilizes user-provided chamber compliance and mitral impedance parameters and returns the time course of chamber pressure and mitral velocity and flow. The authors describe their initial experience with an algorithm to invert the model, i.e. to analyze observed pressure and flow data and extract the compliance and impedance parameters underlying the observed curves. This algorithm repeatedly solves the forward model, adjusting the physiologic parameters using the Marquardt method until the fit to the observed pressure and flow data is optimized. This algorithm was tested against computer-generated data with up to 10% Gaussian noise. It has also been validated with data from an in vitro analog of the left heart and from a canine model of mitral stenosis. Other possible inversion schemes, such as those which utilize only noninvasive data, are also discussed.< ></abstract><pub>IEEE Comput. Soc. Press</pub><doi>10.1109/CIC.1989.130467</doi><tpages>6</tpages></addata></record> |
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ispartof | [1989] Proceedings. Computers in Cardiology, 1989, p.9-14 |
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language | eng |
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source | IEEE Electronic Library (IEL) Conference Proceedings |
subjects | Algorithm design and analysis Data mining Filling Gaussian noise Impedance In vitro Mathematical model Optimization methods Pattern analysis Testing |
title | Extracting ventricular and atrial compliance and mitral impedance from Doppler inflow velocity and chamber pressures: inversion of a mitral flow model |
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