Simultaneous measurement of angular and spectral properties of light scattering for characterization of tissue microarchitecture and its alteration in early precancer
We present a novel instrument to measure the spectral, angular, azimuthal, and polarization dependence of light backscattered by living biological tissues, thus providing the most comprehensive description of the light scattering to obtain unique quantitative information about the microarchitecture...
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| Veröffentlicht in: | IEEE journal of selected topics in quantum electronics 2003-03, Vol.9 (2), p.243-256 |
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| container_title | IEEE journal of selected topics in quantum electronics |
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| creator | Kim, Y.L. Yang Liu Wali, R.K. Roy, H.K. Goldberg, M.J. Kromin, A.K. Kun Chen Backman, V. |
| description | We present a novel instrument to measure the spectral, angular, azimuthal, and polarization dependence of light backscattered by living biological tissues, thus providing the most comprehensive description of the light scattering to obtain unique quantitative information about the microarchitecture of living cells and tissues. We show the potential of this technique to characterize and diagnose early premalignant changes in the epithelia. In studies with a rodent model of colon carcinogenesis, we show that several parameters obtained using this technique, such as the number density of red blood cells in the capillary network immediately underlying the epithelium, the fractal dimension of the tissue, and the average roundness of subcellular structures, are significant for detection of precancerous changes at a very early stage of the carcinogenic process, at which no other histological or molecular markers have been identified. |
| doi_str_mv | 10.1109/JSTQE.2003.814183 |
| format | Article |
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We show the potential of this technique to characterize and diagnose early premalignant changes in the epithelia. In studies with a rodent model of colon carcinogenesis, we show that several parameters obtained using this technique, such as the number density of red blood cells in the capillary network immediately underlying the epithelium, the fractal dimension of the tissue, and the average roundness of subcellular structures, are significant for detection of precancerous changes at a very early stage of the carcinogenic process, at which no other histological or molecular markers have been identified.</description><identifier>ISSN: 1077-260X</identifier><identifier>EISSN: 1558-4542</identifier><identifier>DOI: 10.1109/JSTQE.2003.814183</identifier><identifier>CODEN: IJSQEN</identifier><language>eng</language><publisher>New York: IEEE</publisher><subject>Biological system modeling ; Biological tissues ; Carcinogens ; Cells (biology) ; Colon ; Density ; Fractal analysis ; Instruments ; Light scattering ; Mathematical models ; Microarchitecture ; Molecular structure ; Optical polarization ; Red blood cells ; Rodents ; Spectra</subject><ispartof>IEEE journal of selected topics in quantum electronics, 2003-03, Vol.9 (2), p.243-256</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-bc483b9faa2324177768be3990e63f89afc26600a09884763fa91c39f3addff43</citedby><cites>FETCH-LOGICAL-c354t-bc483b9faa2324177768be3990e63f89afc26600a09884763fa91c39f3addff43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/1238988$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,777,781,793,27905,27906,54739</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/1238988$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Kim, Y.L.</creatorcontrib><creatorcontrib>Yang Liu</creatorcontrib><creatorcontrib>Wali, R.K.</creatorcontrib><creatorcontrib>Roy, H.K.</creatorcontrib><creatorcontrib>Goldberg, M.J.</creatorcontrib><creatorcontrib>Kromin, A.K.</creatorcontrib><creatorcontrib>Kun Chen</creatorcontrib><creatorcontrib>Backman, V.</creatorcontrib><title>Simultaneous measurement of angular and spectral properties of light scattering for characterization of tissue microarchitecture and its alteration in early precancer</title><title>IEEE journal of selected topics in quantum electronics</title><addtitle>JSTQE</addtitle><description>We present a novel instrument to measure the spectral, angular, azimuthal, and polarization dependence of light backscattered by living biological tissues, thus providing the most comprehensive description of the light scattering to obtain unique quantitative information about the microarchitecture of living cells and tissues. We show the potential of this technique to characterize and diagnose early premalignant changes in the epithelia. In studies with a rodent model of colon carcinogenesis, we show that several parameters obtained using this technique, such as the number density of red blood cells in the capillary network immediately underlying the epithelium, the fractal dimension of the tissue, and the average roundness of subcellular structures, are significant for detection of precancerous changes at a very early stage of the carcinogenic process, at which no other histological or molecular markers have been identified.</description><subject>Biological system modeling</subject><subject>Biological tissues</subject><subject>Carcinogens</subject><subject>Cells (biology)</subject><subject>Colon</subject><subject>Density</subject><subject>Fractal analysis</subject><subject>Instruments</subject><subject>Light scattering</subject><subject>Mathematical models</subject><subject>Microarchitecture</subject><subject>Molecular structure</subject><subject>Optical polarization</subject><subject>Red blood cells</subject><subject>Rodents</subject><subject>Spectra</subject><issn>1077-260X</issn><issn>1558-4542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNp9kc1q3TAQhU1poGnSByjdiC5KN77Vny1pWULSHwKhJIXuxFzd0b0Ksn0ryYvkgfqcleNCoYuuZhi-OcOZ0zSvGd0wRs2Hr7d33y43nFKx0UwyLZ41p6zrdCs7yZ_XnirV8p7-eNG8zPmeUqqlpqfNr9swzLHAiNOcyYCQ54QDjoVMnsC4nyOkWnckH9GVBJEc03TEVALmBYlhfygkOygFUxj3xE-JuAMkcMvgEUqYxgUsIecZyRBcmiC5QyhVr956Eg8lE4h1YcXDSBBSfKi30MHoMJ03Jx5ixld_6lnz_ery7uJze33z6cvFx-vWiU6WduukFlvjAbjgkimler1FYQzFXnhtwDve95QCNVpLVWdgmBPGC9jtvJfirHm36laXP2fMxQ4hO4xxfZDlutNVtKvg-_-CrFdMUCU1r-jbf9D7aU5jtWEN56ZTNaYKsRWq78k5obfHFAZID5ZRuyRsnxK2S8J2TbjuvFl3AiL-5bnQ1Z34DccQpvE</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Kim, Y.L.</creator><creator>Yang Liu</creator><creator>Wali, R.K.</creator><creator>Roy, H.K.</creator><creator>Goldberg, M.J.</creator><creator>Kromin, A.K.</creator><creator>Kun Chen</creator><creator>Backman, V.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>RIA</scope><scope>RIE</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>20030301</creationdate><title>Simultaneous measurement of angular and spectral properties of light scattering for characterization of tissue microarchitecture and its alteration in early precancer</title><author>Kim, Y.L. ; Yang Liu ; Wali, R.K. ; Roy, H.K. ; Goldberg, M.J. ; Kromin, A.K. ; Kun Chen ; Backman, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-bc483b9faa2324177768be3990e63f89afc26600a09884763fa91c39f3addff43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological system modeling</topic><topic>Biological tissues</topic><topic>Carcinogens</topic><topic>Cells (biology)</topic><topic>Colon</topic><topic>Density</topic><topic>Fractal analysis</topic><topic>Instruments</topic><topic>Light scattering</topic><topic>Mathematical models</topic><topic>Microarchitecture</topic><topic>Molecular structure</topic><topic>Optical polarization</topic><topic>Red blood cells</topic><topic>Rodents</topic><topic>Spectra</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Y.L.</creatorcontrib><creatorcontrib>Yang Liu</creatorcontrib><creatorcontrib>Wali, R.K.</creatorcontrib><creatorcontrib>Roy, H.K.</creatorcontrib><creatorcontrib>Goldberg, M.J.</creatorcontrib><creatorcontrib>Kromin, A.K.</creatorcontrib><creatorcontrib>Kun Chen</creatorcontrib><creatorcontrib>Backman, V.</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>IEEE journal of selected topics in quantum electronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kim, Y.L.</au><au>Yang Liu</au><au>Wali, R.K.</au><au>Roy, H.K.</au><au>Goldberg, M.J.</au><au>Kromin, A.K.</au><au>Kun Chen</au><au>Backman, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous measurement of angular and spectral properties of light scattering for characterization of tissue microarchitecture and its alteration in early precancer</atitle><jtitle>IEEE journal of selected topics in quantum electronics</jtitle><stitle>JSTQE</stitle><date>2003-03-01</date><risdate>2003</risdate><volume>9</volume><issue>2</issue><spage>243</spage><epage>256</epage><pages>243-256</pages><issn>1077-260X</issn><eissn>1558-4542</eissn><coden>IJSQEN</coden><abstract>We present a novel instrument to measure the spectral, angular, azimuthal, and polarization dependence of light backscattered by living biological tissues, thus providing the most comprehensive description of the light scattering to obtain unique quantitative information about the microarchitecture of living cells and tissues. We show the potential of this technique to characterize and diagnose early premalignant changes in the epithelia. In studies with a rodent model of colon carcinogenesis, we show that several parameters obtained using this technique, such as the number density of red blood cells in the capillary network immediately underlying the epithelium, the fractal dimension of the tissue, and the average roundness of subcellular structures, are significant for detection of precancerous changes at a very early stage of the carcinogenic process, at which no other histological or molecular markers have been identified.</abstract><cop>New York</cop><pub>IEEE</pub><doi>10.1109/JSTQE.2003.814183</doi><tpages>14</tpages></addata></record> |
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| subjects | Biological system modeling Biological tissues Carcinogens Cells (biology) Colon Density Fractal analysis Instruments Light scattering Mathematical models Microarchitecture Molecular structure Optical polarization Red blood cells Rodents Spectra |
| title | Simultaneous measurement of angular and spectral properties of light scattering for characterization of tissue microarchitecture and its alteration in early precancer |
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