Kwong-Li probes: novel nano-probes for biological dissection and injection
We recently discovered a very fast and reliable single-step etching process to fabricate tiny-angled (
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| creator | Kwong, C.C.H. Lai, K.W.C. Ruiguang Yan Li, W.J. |
| description | We recently discovered a very fast and reliable single-step etching process to fabricate tiny-angled ( |
| doi_str_mv | 10.1109/AIM.2003.1225461 |
| format | Conference Proceeding |
| fullrecord | <record><control><sourceid>ieee_6IE</sourceid><recordid>TN_cdi_ieee_primary_1225461</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ieee_id>1225461</ieee_id><sourcerecordid>1225461</sourcerecordid><originalsourceid>FETCH-LOGICAL-i173t-efb69786edddf4908e482eb0a4e6f3bb9ee752679f213194204071ce6acb5bf23</originalsourceid><addsrcrecordid>eNotj81KAzEYRQMiqLV7wU1eYMYv_xN3pfhTHXGj65JMvpSUMSmTovj2CtO7uZy7OHAJuWHQMgb2brV5azmAaBnnSmp2Rq7AdCCMUZZdkGWte_iPsEIpdUleXn9K3jV9ooepeKz3NJdvHGl2uTTzRGOZqE9lLLs0uJGGVCsOx1QydTnQlPczXZPz6MaKy1MvyOfjw8f6uenfnzbrVd8kZsSxwei1NZ3GEEKUFjqUHUcPTqKOwnuLaBTXxkbOBLOSgwTDBtRu8MpHLhbkdvYmRNwepvTlpt_t6a74AwinS2I</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>conference_proceeding</recordtype></control><display><type>conference_proceeding</type><title>Kwong-Li probes: novel nano-probes for biological dissection and injection</title><source>IEEE Electronic Library (IEL) Conference Proceedings</source><creator>Kwong, C.C.H. ; Lai, K.W.C. ; Ruiguang Yan ; Li, W.J.</creator><creatorcontrib>Kwong, C.C.H. ; Lai, K.W.C. ; Ruiguang Yan ; Li, W.J.</creatorcontrib><description>We recently discovered a very fast and reliable single-step etching process to fabricate tiny-angled (<2.7/spl deg/) fiber probe tips, which is less complex and yields finer tips than other available multiple-step sharp-tip (e.g., SNOM tips) fabrication processes. The process is named as Kwong-Li's (KL) Method. As the probe profile depends highly on the interfacial meniscus of the etchant, by means of our sacrificial boundary etching technique, in which we introduced glass tubing as etching barriers, probes with very sharp tips and long tapers were formed. Using p-xylene as organic solvent and hydrofluoric acid as etchant, we succeeded in shaping optical fibers (with initial fiber diameter of 125 /spl mu/m) into sharp tips with angles ranging front <2.7-9.7/spl deg/, with nanoscale tip diameter of <1 /spl mu/m. By adjusting the initial etchant height in the tubing, final tip angles can be controlled. With their nanometric tips, these sharp probes will be useful for various scanning probe microscopy applications and could potentially be used as surgical tools for micro cellular surgery, i.e., we have already shown that KL probes will penetrate through cell membranes with less mechanical resistance than conventional pipettes and probes made by Turner's Method. The fabrication process of KL probes and experimental results from using KL probes to probe cells are presented in this paper.</description><identifier>ISBN: 0780377591</identifier><identifier>ISBN: 9780780377592</identifier><identifier>DOI: 10.1109/AIM.2003.1225461</identifier><language>eng</language><publisher>IEEE</publisher><subject>Biomembranes ; Cells (biology) ; Etching ; Fabrication ; Glass ; Nanobioscience ; Optical fibers ; Scanning probe microscopy ; Solvents ; Surgery</subject><ispartof>Proceedings 2003 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM 2003), 2003, Vol.2, p.897-901 vol.2</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/1225461$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>310,311,782,786,791,792,2060,4052,4053,27932,54927</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/1225461$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Kwong, C.C.H.</creatorcontrib><creatorcontrib>Lai, K.W.C.</creatorcontrib><creatorcontrib>Ruiguang Yan</creatorcontrib><creatorcontrib>Li, W.J.</creatorcontrib><title>Kwong-Li probes: novel nano-probes for biological dissection and injection</title><title>Proceedings 2003 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM 2003)</title><addtitle>AIM</addtitle><description>We recently discovered a very fast and reliable single-step etching process to fabricate tiny-angled (<2.7/spl deg/) fiber probe tips, which is less complex and yields finer tips than other available multiple-step sharp-tip (e.g., SNOM tips) fabrication processes. The process is named as Kwong-Li's (KL) Method. As the probe profile depends highly on the interfacial meniscus of the etchant, by means of our sacrificial boundary etching technique, in which we introduced glass tubing as etching barriers, probes with very sharp tips and long tapers were formed. Using p-xylene as organic solvent and hydrofluoric acid as etchant, we succeeded in shaping optical fibers (with initial fiber diameter of 125 /spl mu/m) into sharp tips with angles ranging front <2.7-9.7/spl deg/, with nanoscale tip diameter of <1 /spl mu/m. By adjusting the initial etchant height in the tubing, final tip angles can be controlled. With their nanometric tips, these sharp probes will be useful for various scanning probe microscopy applications and could potentially be used as surgical tools for micro cellular surgery, i.e., we have already shown that KL probes will penetrate through cell membranes with less mechanical resistance than conventional pipettes and probes made by Turner's Method. The fabrication process of KL probes and experimental results from using KL probes to probe cells are presented in this paper.</description><subject>Biomembranes</subject><subject>Cells (biology)</subject><subject>Etching</subject><subject>Fabrication</subject><subject>Glass</subject><subject>Nanobioscience</subject><subject>Optical fibers</subject><subject>Scanning probe microscopy</subject><subject>Solvents</subject><subject>Surgery</subject><isbn>0780377591</isbn><isbn>9780780377592</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2003</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNotj81KAzEYRQMiqLV7wU1eYMYv_xN3pfhTHXGj65JMvpSUMSmTovj2CtO7uZy7OHAJuWHQMgb2brV5azmAaBnnSmp2Rq7AdCCMUZZdkGWte_iPsEIpdUleXn9K3jV9ooepeKz3NJdvHGl2uTTzRGOZqE9lLLs0uJGGVCsOx1QydTnQlPczXZPz6MaKy1MvyOfjw8f6uenfnzbrVd8kZsSxwei1NZ3GEEKUFjqUHUcPTqKOwnuLaBTXxkbOBLOSgwTDBtRu8MpHLhbkdvYmRNwepvTlpt_t6a74AwinS2I</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Kwong, C.C.H.</creator><creator>Lai, K.W.C.</creator><creator>Ruiguang Yan</creator><creator>Li, W.J.</creator><general>IEEE</general><scope>6IE</scope><scope>6IL</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIL</scope></search><sort><creationdate>2003</creationdate><title>Kwong-Li probes: novel nano-probes for biological dissection and injection</title><author>Kwong, C.C.H. ; Lai, K.W.C. ; Ruiguang Yan ; Li, W.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i173t-efb69786edddf4908e482eb0a4e6f3bb9ee752679f213194204071ce6acb5bf23</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biomembranes</topic><topic>Cells (biology)</topic><topic>Etching</topic><topic>Fabrication</topic><topic>Glass</topic><topic>Nanobioscience</topic><topic>Optical fibers</topic><topic>Scanning probe microscopy</topic><topic>Solvents</topic><topic>Surgery</topic><toplevel>online_resources</toplevel><creatorcontrib>Kwong, C.C.H.</creatorcontrib><creatorcontrib>Lai, K.W.C.</creatorcontrib><creatorcontrib>Ruiguang Yan</creatorcontrib><creatorcontrib>Li, W.J.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kwong, C.C.H.</au><au>Lai, K.W.C.</au><au>Ruiguang Yan</au><au>Li, W.J.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Kwong-Li probes: novel nano-probes for biological dissection and injection</atitle><btitle>Proceedings 2003 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM 2003)</btitle><stitle>AIM</stitle><date>2003</date><risdate>2003</risdate><volume>2</volume><spage>897</spage><epage>901 vol.2</epage><pages>897-901 vol.2</pages><isbn>0780377591</isbn><isbn>9780780377592</isbn><abstract>We recently discovered a very fast and reliable single-step etching process to fabricate tiny-angled (<2.7/spl deg/) fiber probe tips, which is less complex and yields finer tips than other available multiple-step sharp-tip (e.g., SNOM tips) fabrication processes. The process is named as Kwong-Li's (KL) Method. As the probe profile depends highly on the interfacial meniscus of the etchant, by means of our sacrificial boundary etching technique, in which we introduced glass tubing as etching barriers, probes with very sharp tips and long tapers were formed. Using p-xylene as organic solvent and hydrofluoric acid as etchant, we succeeded in shaping optical fibers (with initial fiber diameter of 125 /spl mu/m) into sharp tips with angles ranging front <2.7-9.7/spl deg/, with nanoscale tip diameter of <1 /spl mu/m. By adjusting the initial etchant height in the tubing, final tip angles can be controlled. With their nanometric tips, these sharp probes will be useful for various scanning probe microscopy applications and could potentially be used as surgical tools for micro cellular surgery, i.e., we have already shown that KL probes will penetrate through cell membranes with less mechanical resistance than conventional pipettes and probes made by Turner's Method. The fabrication process of KL probes and experimental results from using KL probes to probe cells are presented in this paper.</abstract><pub>IEEE</pub><doi>10.1109/AIM.2003.1225461</doi></addata></record> |
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| identifier | ISBN: 0780377591 |
| ispartof | Proceedings 2003 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM 2003), 2003, Vol.2, p.897-901 vol.2 |
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| language | eng |
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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Biomembranes Cells (biology) Etching Fabrication Glass Nanobioscience Optical fibers Scanning probe microscopy Solvents Surgery |
| title | Kwong-Li probes: novel nano-probes for biological dissection and injection |
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