Investigation of Deficiency of Serum Glucose-6-Phosphate Dehydrogenase Enzyme Level Around and in Mardin Province

Introduction: Glucose-6-phosphate dehydrogenase (G6PD) is a cytosolic enzyme, and the first enzyme to catalyze the pentose phosphate pathway. Our aim is to investigate the G6PD enzyme activity in Mardin province. Methods: Our study was divided into subgroups according to gender, age, and G6PD levels. A total of 439 individuals, 168 females and 271 males, between the ages of 2 and 80 were included in the study. G6PD enzyme activity was measured by the photometric method using the AU5800 Beckman device. Results: G6PD enzyme activity in the Mardin region was found to be 13.95±7.29 U/gHb. The mean G6PD enzyme activity in female patients was 14.22±6.98 U/gHb, and the mean in male patients was 13.78±7.48 U/gHb (p>0.05). When evaluated in terms of age, the G6PD enzyme activity was 14.93 (0.03-38.47) in patients aged 2-19, 13.76 (0.01-30.79) between 20-35 years old, 17.05 between 36-50 years old (0.13-27.21), 13.75 (0.05-26.99) U/gHb between 51-80 years old (p=0.301). Conclusion: In our study, no significant difference was found between G6PD enzyme activity in terms of age and gender. G6PD enzyme deficiency was shown as 6% relative to the reference range. A deficiency of 6.5% in male and 3.5% in female was observed. This study is valuable in that it is the first study conducted in Mardin. There is a need for larger studies to support this study locally. Giriş: Glukoz-6-fosfat dehidrogenaz (G6PD) sitosolik bir enzim olup pentoz fosfat yolunu katalizleyen ilk enzimdir. Bu çalışmadaki amacımız Mardin ve çevresinde hastaneye başvuran hastaların G6PD enzim düzeyini ve eksiklik sıklığını araştırmaktır. Yöntem: Mardin Eğitim ve Araştırma Hastanesine gelen hastaların G6PD enzim aktivitesi retrospektif olarak değerlendirildi. Çalışmamız cinsiyet, yaş ve G6PD seviyelerine göre alt gruplara ayrıldı. Yaş aralığı 2-80 arasında 168 kadın ve 271 erkek olmak üzere 439 birey çalışmaya dahil edildi. G6PD enzim aktivitesi AU5800 Beckman cihazı kullanılarak fotometrik yöntemle ölçüldü. Bulgular: Çalışmamızda G6PD enzim aktivitesi 13.95±7.29 Ü/gHb olarak tespit edildi. Kadın hastalarda G6PD enzim aktivitesi ortalaması 14.22±6.98 Ü/gHb erkek hastalarda ise 13.78±7.48 Ü/gHb olarak bulundu (p>0.05). Yaş açısından değerlendirildiğinde 2-19 yaş aralığındaki hastalarda G6PD aktivitesi 14.93(0.03- 38.47), 20-35 yaş arası 13.76 (0.01- 30.79), 36-50 yaş arası 17.05 (0.13- 27.21), 51-80 yaş arası 13.75(0.05- 26.99) Ü/gHb olarak tespit edildi (p=0.301). Sonuç: Çalışmamızda yaş ve cinsiyet aç