Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey
Background and Aims: This study aims to investigate the cytotoxicity and DNA protective effects of semi-arid, arid, or desert truffles such as the Terfezia and Picoa species. Methods: The DNA protective effects of the Terfezia and Picoa species was evaluated using plasmid pBR322 DNA treated with UV...
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| Veröffentlicht in: | Istanbul Journal of Pharmacy 2021-08, Vol.51 (2), p.198-203 |
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| container_title | Istanbul Journal of Pharmacy |
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| creator | Akyuz, Mehmet Karagoz, Isik Didem Inci, Sule Kilic, Ibrahim Halil Kirbag, Sevda Simitcioglu, Basak |
| description | Background and Aims: This study aims to investigate the cytotoxicity and DNA protective effects of semi-arid, arid, or desert truffles such as the Terfezia and Picoa species. Methods: The DNA protective effects of the Terfezia and Picoa species was evaluated using plasmid pBR322 DNA treated with UV and [H.sub.2][O.sub.2]. The cytotoxic effects of water and methanol extracts of the Terfezia and Picoa species on H1299 and HUVEC cells were evaluated using the MTT assay. Results: Higher concentrations of T. olbiensisand P. lefebvreiextracts have demonstrated a DNA protective effect. The water extract of P. juniperi only at a 40 mg/mL concentration demonstrated a DNA-protective effect, whereas T. boudieri extract did not show any DNA-protective effect at all concentrations tested. H1299 cells showed more sensitivity to the water extract of T. olbiensis (4.66%), P. juniperi (12.04%), P. lefebvrei (21.93%), and the methanol extract of T. boudieri (20.93%). In general, the water and methanol extracts of the Terfezia and Picoa species demonstrated the least cytotoxic effects on HUVEC cells, except for the water extract of P. juniperi (38.46%). Conclusions: In conclusion, results obtained from this study show that the Terfezia and Picoa truffle species have potential DNA protective and cancer prevention properties. Keywords: arid-semi arid truffle, DNA protective activity, cytotoxicity effect, mushroom, Terfezia, Picoa |
| doi_str_mv | 10.26650/IstanbulJPharm.2020.0064 |
| format | Article |
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Methods: The DNA protective effects of the Terfezia and Picoa species was evaluated using plasmid pBR322 DNA treated with UV and [H.sub.2][O.sub.2]. The cytotoxic effects of water and methanol extracts of the Terfezia and Picoa species on H1299 and HUVEC cells were evaluated using the MTT assay. Results: Higher concentrations of T. olbiensisand P. lefebvreiextracts have demonstrated a DNA protective effect. The water extract of P. juniperi only at a 40 mg/mL concentration demonstrated a DNA-protective effect, whereas T. boudieri extract did not show any DNA-protective effect at all concentrations tested. H1299 cells showed more sensitivity to the water extract of T. olbiensis (4.66%), P. juniperi (12.04%), P. lefebvrei (21.93%), and the methanol extract of T. boudieri (20.93%). In general, the water and methanol extracts of the Terfezia and Picoa species demonstrated the least cytotoxic effects on HUVEC cells, except for the water extract of P. juniperi (38.46%). Conclusions: In conclusion, results obtained from this study show that the Terfezia and Picoa truffle species have potential DNA protective and cancer prevention properties. Keywords: arid-semi arid truffle, DNA protective activity, cytotoxicity effect, mushroom, Terfezia, Picoa</description><identifier>ISSN: 2548-0731</identifier><identifier>ISSN: 2587-2087</identifier><identifier>EISSN: 2587-2087</identifier><identifier>DOI: 10.26650/IstanbulJPharm.2020.0064</identifier><language>eng</language><publisher>AVES</publisher><subject>Analysis ; Cancer ; Deserts ; DNA ; Eczacılık ; Genetic research ; Methanol ; Oncology, Experimental ; Prevention ; Tıp</subject><ispartof>Istanbul Journal of Pharmacy, 2021-08, Vol.51 (2), p.198-203</ispartof><rights>COPYRIGHT 2021 AVES</rights><rights>COPYRIGHT 2021 Istanbul University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><contributor>Özsoy Erginer,Yıldız</contributor><contributor>Akalın Uruşak,Emine</contributor><contributor>Karalı,Nilgün</contributor><creatorcontrib>Akyuz, Mehmet</creatorcontrib><creatorcontrib>Karagoz, Isik Didem</creatorcontrib><creatorcontrib>Inci, Sule</creatorcontrib><creatorcontrib>Kilic, Ibrahim Halil</creatorcontrib><creatorcontrib>Kirbag, Sevda</creatorcontrib><creatorcontrib>Simitcioglu, Basak</creatorcontrib><title>Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey</title><title>Istanbul Journal of Pharmacy</title><description>Background and Aims: This study aims to investigate the cytotoxicity and DNA protective effects of semi-arid, arid, or desert truffles such as the Terfezia and Picoa species. Methods: The DNA protective effects of the Terfezia and Picoa species was evaluated using plasmid pBR322 DNA treated with UV and [H.sub.2][O.sub.2]. The cytotoxic effects of water and methanol extracts of the Terfezia and Picoa species on H1299 and HUVEC cells were evaluated using the MTT assay. Results: Higher concentrations of T. olbiensisand P. lefebvreiextracts have demonstrated a DNA protective effect. The water extract of P. juniperi only at a 40 mg/mL concentration demonstrated a DNA-protective effect, whereas T. boudieri extract did not show any DNA-protective effect at all concentrations tested. H1299 cells showed more sensitivity to the water extract of T. olbiensis (4.66%), P. juniperi (12.04%), P. lefebvrei (21.93%), and the methanol extract of T. boudieri (20.93%). In general, the water and methanol extracts of the Terfezia and Picoa species demonstrated the least cytotoxic effects on HUVEC cells, except for the water extract of P. juniperi (38.46%). Conclusions: In conclusion, results obtained from this study show that the Terfezia and Picoa truffle species have potential DNA protective and cancer prevention properties. Keywords: arid-semi arid truffle, DNA protective activity, cytotoxicity effect, mushroom, Terfezia, Picoa</description><subject>Analysis</subject><subject>Cancer</subject><subject>Deserts</subject><subject>DNA</subject><subject>Eczacılık</subject><subject>Genetic research</subject><subject>Methanol</subject><subject>Oncology, Experimental</subject><subject>Prevention</subject><subject>Tıp</subject><issn>2548-0731</issn><issn>2587-2087</issn><issn>2587-2087</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkE9LAzEQxRdRULTfIeLFy9Ykm38eS1u1UrSHel7S7KSNbhNJUrF-eteqB0FQ5jDD8HvvMVMUpwT3qRAcX0xS1n6xaW9nKx3XfYop7mMs2F5xRLmSJcVK7n_MTJVYVuSw6KXkFpgxyWjF2VHxNNzmkMOrMy5vkfYNGt0N0HMMGUx2L4DA2m5KKFiUV4DmEC28Ob1DZ84EjdIzGAcJ2RjWOwZ0yhA9irB0wX8o55v4BNuT4sDqNkHvqx8XD1fj-fCmnN5fT4aDabkkQorSVtWiskwpRokm2jRay4YDVsxWhDaaN1wKWhnRnciYFcRSJQ1wKaW6FJJWx8X5p69rQLfBt85D_Rg20Xep9WQ0HkxrwplUokPPPtGlbqF23oYctVm7ZOqBkJdYUanoH5QkhHDMOqr_C9VVA-vuUR6s6_Y_bP8p-E54Bxsql2Y</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Akyuz, Mehmet</creator><creator>Karagoz, Isik Didem</creator><creator>Inci, Sule</creator><creator>Kilic, Ibrahim Halil</creator><creator>Kirbag, Sevda</creator><creator>Simitcioglu, Basak</creator><general>AVES</general><general>Istanbul University Press</general><general>İstanbul Üniversitesi Yayınları</general><scope>IEBAR</scope></search><sort><creationdate>20210801</creationdate><title>Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey</title><author>Akyuz, Mehmet ; Karagoz, Isik Didem ; Inci, Sule ; Kilic, Ibrahim Halil ; Kirbag, Sevda ; Simitcioglu, Basak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1676-f33b3f488421a1acdaa7d5e084f312da5d57623c625844f61f287ce5777896723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Cancer</topic><topic>Deserts</topic><topic>DNA</topic><topic>Eczacılık</topic><topic>Genetic research</topic><topic>Methanol</topic><topic>Oncology, Experimental</topic><topic>Prevention</topic><topic>Tıp</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akyuz, Mehmet</creatorcontrib><creatorcontrib>Karagoz, Isik Didem</creatorcontrib><creatorcontrib>Inci, Sule</creatorcontrib><creatorcontrib>Kilic, Ibrahim Halil</creatorcontrib><creatorcontrib>Kirbag, Sevda</creatorcontrib><creatorcontrib>Simitcioglu, Basak</creatorcontrib><collection>Idealonline online kütüphane - Journals</collection><jtitle>Istanbul Journal of Pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akyuz, Mehmet</au><au>Karagoz, Isik Didem</au><au>Inci, Sule</au><au>Kilic, Ibrahim Halil</au><au>Kirbag, Sevda</au><au>Simitcioglu, Basak</au><au>Özsoy Erginer,Yıldız</au><au>Akalın Uruşak,Emine</au><au>Karalı,Nilgün</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey</atitle><jtitle>Istanbul Journal of Pharmacy</jtitle><date>2021-08-01</date><risdate>2021</risdate><volume>51</volume><issue>2</issue><spage>198</spage><epage>203</epage><pages>198-203</pages><issn>2548-0731</issn><issn>2587-2087</issn><eissn>2587-2087</eissn><abstract>Background and Aims: This study aims to investigate the cytotoxicity and DNA protective effects of semi-arid, arid, or desert truffles such as the Terfezia and Picoa species. Methods: The DNA protective effects of the Terfezia and Picoa species was evaluated using plasmid pBR322 DNA treated with UV and [H.sub.2][O.sub.2]. The cytotoxic effects of water and methanol extracts of the Terfezia and Picoa species on H1299 and HUVEC cells were evaluated using the MTT assay. Results: Higher concentrations of T. olbiensisand P. lefebvreiextracts have demonstrated a DNA protective effect. The water extract of P. juniperi only at a 40 mg/mL concentration demonstrated a DNA-protective effect, whereas T. boudieri extract did not show any DNA-protective effect at all concentrations tested. H1299 cells showed more sensitivity to the water extract of T. olbiensis (4.66%), P. juniperi (12.04%), P. lefebvrei (21.93%), and the methanol extract of T. boudieri (20.93%). In general, the water and methanol extracts of the Terfezia and Picoa species demonstrated the least cytotoxic effects on HUVEC cells, except for the water extract of P. juniperi (38.46%). Conclusions: In conclusion, results obtained from this study show that the Terfezia and Picoa truffle species have potential DNA protective and cancer prevention properties. Keywords: arid-semi arid truffle, DNA protective activity, cytotoxicity effect, mushroom, Terfezia, Picoa</abstract><pub>AVES</pub><doi>10.26650/IstanbulJPharm.2020.0064</doi><tpages>6</tpages></addata></record> |
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| source | Alma/SFX Local Collection |
| subjects | Analysis Cancer Deserts DNA Eczacılık Genetic research Methanol Oncology, Experimental Prevention Tıp |
| title | Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey |
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