Effect of Parathyroidectomy Timing in Kidney Transplant Recipients on Graft Function
Persistent hyperparathyroidism can have a deleterious effect on graft function in kidney transplant recipients, although serum calcium, phosphorus, and parathyroid hormone levels tend to normalize after successful transplant. Parathyroidectomy can result in sustained amelioration of persistent hyper...
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| Veröffentlicht in: | Experimental and clinical transplantation 2021-04, Vol.19 (4), p.316-323 |
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| creator | Oruc, Aysegul Ersoy, Alparslan Yildiz, Abdulmecit Oz Gul, Ozen Ersoy, Canan |
| description | Persistent hyperparathyroidism can have a deleterious effect on graft function in kidney transplant recipients, although serum calcium, phosphorus, and parathyroid hormone levels tend to normalize after successful transplant. Parathyroidectomy can result in sustained amelioration of persistent hyperparathyroidism despite graft failure risk and unfavorable graft outcomes. Data on this issue are limited and conflicting. Here, we evaluated the effects of parathyroidectomy on graft function in kidney transplant recipients.
This retrospective study included 249 adult kidney transplant recipients (121 deceased-donor/128 living-donor; 142 males/107 females; mean age of 39.3 ± 11.6 y; mean follow-up of 46.5 ± 23.5 mo). Participants were grouped as those without (n = 222), those with pretransplant (n = 12), and those with posttransplant (n = 15) parathyroidectomy. Graft outcomes and serum calcium, phosphorus, and parathyroid hormone levels were studied.
Serum calcium levels at baseline and at 1, 3, 6, and 12 months and parathyroid hormone levels at baseline and at 6 and 12 months were higher and serum phosphorus levels at 3, 6, and 12 months were lower in the posttransplant parathyroidectomy group versus the other groups (P < .001). We observed no significant differences between groups regarding serum calcium, phosphorus, and parathyroid hormone levels at last visit. Estimated glomerular filtration rates at 3, 6, and 12 months and at last visit in the pretransplant parathyroidectomy group were higher than in those without parathyroidectomy (P < .05) and higher at 6 and 12 months than in the posttransplant parathyroidectomy group (P < .05). No significant differences regarding graft loss and patient mortality were observed among the 3 groups (P > .05).
Parathyroidectomy resulted in sustained decreased levels of serum calcium and parathyroid hormone. We observed no graft failure risk associated with parathyroidectomy in our study. Parathyroidectomy before transplant is advantageous with better graft function. |
| doi_str_mv | 10.6002/ect.2018.0221 |
| format | Article |
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This retrospective study included 249 adult kidney transplant recipients (121 deceased-donor/128 living-donor; 142 males/107 females; mean age of 39.3 ± 11.6 y; mean follow-up of 46.5 ± 23.5 mo). Participants were grouped as those without (n = 222), those with pretransplant (n = 12), and those with posttransplant (n = 15) parathyroidectomy. Graft outcomes and serum calcium, phosphorus, and parathyroid hormone levels were studied.
Serum calcium levels at baseline and at 1, 3, 6, and 12 months and parathyroid hormone levels at baseline and at 6 and 12 months were higher and serum phosphorus levels at 3, 6, and 12 months were lower in the posttransplant parathyroidectomy group versus the other groups (P < .001). We observed no significant differences between groups regarding serum calcium, phosphorus, and parathyroid hormone levels at last visit. Estimated glomerular filtration rates at 3, 6, and 12 months and at last visit in the pretransplant parathyroidectomy group were higher than in those without parathyroidectomy (P < .05) and higher at 6 and 12 months than in the posttransplant parathyroidectomy group (P < .05). No significant differences regarding graft loss and patient mortality were observed among the 3 groups (P > .05).
Parathyroidectomy resulted in sustained decreased levels of serum calcium and parathyroid hormone. We observed no graft failure risk associated with parathyroidectomy in our study. Parathyroidectomy before transplant is advantageous with better graft function.</description><identifier>ISSN: 1304-0855</identifier><identifier>EISSN: 2146-8427</identifier><identifier>DOI: 10.6002/ect.2018.0221</identifier><identifier>PMID: 30346261</identifier><language>eng</language><publisher>Turkey: Başkent Üniversitesi</publisher><subject>Adult ; Calcium - blood ; Female ; Humans ; Hyperparathyroidism - complications ; Hyperparathyroidism - diagnosis ; Kidney Transplantation ; Male ; Middle Aged ; Parathyroid Hormone - blood ; Parathyroidectomy ; Phosphorus - blood ; Retrospective Studies ; Tıp ; Treatment Outcome</subject><ispartof>Experimental and clinical transplantation, 2021-04, Vol.19 (4), p.316-323</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-53700bdbcef8716e097a427beeb1cdb53776d31caf8a1be46b58b0316b5ec8113</citedby><cites>FETCH-LOGICAL-c392t-53700bdbcef8716e097a427beeb1cdb53776d31caf8a1be46b58b0316b5ec8113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30346261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Haberal,Mehmet</contributor><creatorcontrib>Oruc, Aysegul</creatorcontrib><creatorcontrib>Ersoy, Alparslan</creatorcontrib><creatorcontrib>Yildiz, Abdulmecit</creatorcontrib><creatorcontrib>Oz Gul, Ozen</creatorcontrib><creatorcontrib>Ersoy, Canan</creatorcontrib><title>Effect of Parathyroidectomy Timing in Kidney Transplant Recipients on Graft Function</title><title>Experimental and clinical transplantation</title><addtitle>Exp Clin Transplant</addtitle><description>Persistent hyperparathyroidism can have a deleterious effect on graft function in kidney transplant recipients, although serum calcium, phosphorus, and parathyroid hormone levels tend to normalize after successful transplant. Parathyroidectomy can result in sustained amelioration of persistent hyperparathyroidism despite graft failure risk and unfavorable graft outcomes. Data on this issue are limited and conflicting. Here, we evaluated the effects of parathyroidectomy on graft function in kidney transplant recipients.
This retrospective study included 249 adult kidney transplant recipients (121 deceased-donor/128 living-donor; 142 males/107 females; mean age of 39.3 ± 11.6 y; mean follow-up of 46.5 ± 23.5 mo). Participants were grouped as those without (n = 222), those with pretransplant (n = 12), and those with posttransplant (n = 15) parathyroidectomy. Graft outcomes and serum calcium, phosphorus, and parathyroid hormone levels were studied.
Serum calcium levels at baseline and at 1, 3, 6, and 12 months and parathyroid hormone levels at baseline and at 6 and 12 months were higher and serum phosphorus levels at 3, 6, and 12 months were lower in the posttransplant parathyroidectomy group versus the other groups (P < .001). We observed no significant differences between groups regarding serum calcium, phosphorus, and parathyroid hormone levels at last visit. Estimated glomerular filtration rates at 3, 6, and 12 months and at last visit in the pretransplant parathyroidectomy group were higher than in those without parathyroidectomy (P < .05) and higher at 6 and 12 months than in the posttransplant parathyroidectomy group (P < .05). No significant differences regarding graft loss and patient mortality were observed among the 3 groups (P > .05).
Parathyroidectomy resulted in sustained decreased levels of serum calcium and parathyroid hormone. We observed no graft failure risk associated with parathyroidectomy in our study. Parathyroidectomy before transplant is advantageous with better graft function.</description><subject>Adult</subject><subject>Calcium - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperparathyroidism - complications</subject><subject>Hyperparathyroidism - diagnosis</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parathyroid Hormone - blood</subject><subject>Parathyroidectomy</subject><subject>Phosphorus - blood</subject><subject>Retrospective Studies</subject><subject>Tıp</subject><subject>Treatment Outcome</subject><issn>1304-0855</issn><issn>2146-8427</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LAzEQxYMottQevUqOXrbma5P0WGpbxYIi9RySbKKR3aRkt4f-96ZUPT148-PNzAPgFqMZR4g8ODvMCMJyhgjBF2BMMOOVZERcgjGmiFVI1vUITPs-GMSYEIRxeQ1GFFHGCcdjsFt5X1Jg8vBNZz18HXMKTXFSd4S70IX4CUOEL6GJrhhZx37f6jjAd2fDPrg49DBFuMnaD3B9iHYIKd6AK6_b3k1_dQI-1qvd8qnavm6el4ttZemcDFVNBUKmMdZ5KTB3aC50ud04Z7BtTBkL3lBstZcaG8e4qaVBFBd1VmJMJ-D-nFsu1m2KbYhOfadDjmWren5cLbYKUyyILGh1Rm1OfZ-dV_scOp2PCiN16lKVn9WpS3XqsvB3Z35_MJ1r_um_5ugPUoRvwA</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Oruc, Aysegul</creator><creator>Ersoy, Alparslan</creator><creator>Yildiz, Abdulmecit</creator><creator>Oz Gul, Ozen</creator><creator>Ersoy, Canan</creator><general>Başkent Üniversitesi</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IEBAR</scope></search><sort><creationdate>20210401</creationdate><title>Effect of Parathyroidectomy Timing in Kidney Transplant Recipients on Graft Function</title><author>Oruc, Aysegul ; Ersoy, Alparslan ; Yildiz, Abdulmecit ; Oz Gul, Ozen ; Ersoy, Canan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-53700bdbcef8716e097a427beeb1cdb53776d31caf8a1be46b58b0316b5ec8113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Calcium - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperparathyroidism - complications</topic><topic>Hyperparathyroidism - diagnosis</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parathyroid Hormone - blood</topic><topic>Parathyroidectomy</topic><topic>Phosphorus - blood</topic><topic>Retrospective Studies</topic><topic>Tıp</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oruc, Aysegul</creatorcontrib><creatorcontrib>Ersoy, Alparslan</creatorcontrib><creatorcontrib>Yildiz, Abdulmecit</creatorcontrib><creatorcontrib>Oz Gul, Ozen</creatorcontrib><creatorcontrib>Ersoy, Canan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Idealonline online kütüphane - Journals</collection><jtitle>Experimental and clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oruc, Aysegul</au><au>Ersoy, Alparslan</au><au>Yildiz, Abdulmecit</au><au>Oz Gul, Ozen</au><au>Ersoy, Canan</au><au>Haberal,Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Parathyroidectomy Timing in Kidney Transplant Recipients on Graft Function</atitle><jtitle>Experimental and clinical transplantation</jtitle><addtitle>Exp Clin Transplant</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>19</volume><issue>4</issue><spage>316</spage><epage>323</epage><pages>316-323</pages><issn>1304-0855</issn><eissn>2146-8427</eissn><abstract>Persistent hyperparathyroidism can have a deleterious effect on graft function in kidney transplant recipients, although serum calcium, phosphorus, and parathyroid hormone levels tend to normalize after successful transplant. Parathyroidectomy can result in sustained amelioration of persistent hyperparathyroidism despite graft failure risk and unfavorable graft outcomes. Data on this issue are limited and conflicting. Here, we evaluated the effects of parathyroidectomy on graft function in kidney transplant recipients.
This retrospective study included 249 adult kidney transplant recipients (121 deceased-donor/128 living-donor; 142 males/107 females; mean age of 39.3 ± 11.6 y; mean follow-up of 46.5 ± 23.5 mo). Participants were grouped as those without (n = 222), those with pretransplant (n = 12), and those with posttransplant (n = 15) parathyroidectomy. Graft outcomes and serum calcium, phosphorus, and parathyroid hormone levels were studied.
Serum calcium levels at baseline and at 1, 3, 6, and 12 months and parathyroid hormone levels at baseline and at 6 and 12 months were higher and serum phosphorus levels at 3, 6, and 12 months were lower in the posttransplant parathyroidectomy group versus the other groups (P < .001). We observed no significant differences between groups regarding serum calcium, phosphorus, and parathyroid hormone levels at last visit. Estimated glomerular filtration rates at 3, 6, and 12 months and at last visit in the pretransplant parathyroidectomy group were higher than in those without parathyroidectomy (P < .05) and higher at 6 and 12 months than in the posttransplant parathyroidectomy group (P < .05). No significant differences regarding graft loss and patient mortality were observed among the 3 groups (P > .05).
Parathyroidectomy resulted in sustained decreased levels of serum calcium and parathyroid hormone. We observed no graft failure risk associated with parathyroidectomy in our study. Parathyroidectomy before transplant is advantageous with better graft function.</abstract><cop>Turkey</cop><pub>Başkent Üniversitesi</pub><pmid>30346261</pmid><doi>10.6002/ect.2018.0221</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Calcium - blood Female Humans Hyperparathyroidism - complications Hyperparathyroidism - diagnosis Kidney Transplantation Male Middle Aged Parathyroid Hormone - blood Parathyroidectomy Phosphorus - blood Retrospective Studies Tıp Treatment Outcome |
| title | Effect of Parathyroidectomy Timing in Kidney Transplant Recipients on Graft Function |
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