Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation
The aim of the present study was to develop and characterize coated chitosan-alginate beads containing cefaclor as a controlled release delivery system. Coated cefaclor beads were prepared by solvent evaporation techniques. Beads were found to be intact and spherical in shape. Their size range was 1...
Gespeichert in:
| Veröffentlicht in: | Acta Pharmaceutica 2013-03, Vol.63 (1), p.31-44 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 44 |
|---|---|
| container_issue | 1 |
| container_start_page | 31 |
| container_title | Acta Pharmaceutica |
| container_volume | 63 |
| creator | Rasool, Bazigha K Abdul Fahmy, Sahar A |
| description | The aim of the present study was to develop and characterize coated chitosan-alginate beads containing cefaclor as a controlled release delivery system. Coated cefaclor beads were prepared by solvent evaporation techniques. Beads were found to be intact and spherical in shape. Their size range was 1.05 to 2.06. The loading efficiency showed maximum value when the concentration of cefaclor, chitosan and PEG 400 was 10 % (m/V), 0.5 % (m/V) and 2 % (V/V), respectively. Best retardation of cefaclor release from chitosan-alginate beads was achieved by coating with 15 % of shellac in formula F19. A significant antimicrobial activity (p < 0.05) against Staphylococcus aureus and Klebsiella pneumoniae was observed for formula F19 compared to the standard antibiotic disc. Furthermore, the simulated plasma profile showed the superiority of F19 in sustaining drug release for more than 12 h. Therefore, shellac coated chitosan-alginate beads could be considered a successful controlled release oral cefaclor dosage form. |
| doi_str_mv | 10.2478/acph-2013-0003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hrcak</sourceid><recordid>TN_cdi_hrcak_primary_oai_hrcak_srce_hr_96017</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2948707141</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-3b411441d31e20148d8a364bdbbdbe708b15dd7cf24fcb8aed977da6c5d524a83</originalsourceid><addsrcrecordid>eNpdkctLxDAQh4Morq-rRyl48WA1zybrTXyD4EUPnkKaTNmu2WZN2gX_e1NX9yAEMvzyZZjhQ-iY4AvKpbo0djkrKSasxBizLbRHFK_KqRBqO9eM4ZxLMUH7Kc0x5lIquosmlHFFGSF76P0WVuDDcgFdX4SmsMH04IoajEtFE2IRovE57foYvM8vDny7gvj1A0NjrA_xqnjqilWbkQJWxg-mb0N3iHYa4xMc_d4H6O3-7vXmsXx-eXi6uX4uLa-qvmQ1J4Rz4hiBvAdXThlW8drV-YDEqibCOWkbyhtbKwNuKqUzlRVOUG4UO0Dn676zaM2HXsZ2YeKXDqbV6yRFC7nU0woTmfGzNb6M4XOA1OtFmyx4bzoIQ9KEEcnxtKIjevoPnYchdnmZTFElBBYVztTFmrIxpBSh2YxAsB4d6dGRHh3p0VH-cPLbdqgX4Db4nxT2DUGRjaU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1328550560</pqid></control><display><type>article</type><title>Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation</title><source>Open Access: DOAJ - Directory of Open Access Journals</source><source>MEDLINE</source><source>Walter De Gruyter: Open Access Journals</source><source>Free E-Journal (出版社公開部分のみ）</source><creator>Rasool, Bazigha K Abdul ; Fahmy, Sahar A</creator><creatorcontrib>Rasool, Bazigha K Abdul ; Fahmy, Sahar A</creatorcontrib><description>The aim of the present study was to develop and characterize coated chitosan-alginate beads containing cefaclor as a controlled release delivery system. Coated cefaclor beads were prepared by solvent evaporation techniques. Beads were found to be intact and spherical in shape. Their size range was 1.05 to 2.06. The loading efficiency showed maximum value when the concentration of cefaclor, chitosan and PEG 400 was 10 % (m/V), 0.5 % (m/V) and 2 % (V/V), respectively. Best retardation of cefaclor release from chitosan-alginate beads was achieved by coating with 15 % of shellac in formula F19. A significant antimicrobial activity (p < 0.05) against Staphylococcus aureus and Klebsiella pneumoniae was observed for formula F19 compared to the standard antibiotic disc. Furthermore, the simulated plasma profile showed the superiority of F19 in sustaining drug release for more than 12 h. Therefore, shellac coated chitosan-alginate beads could be considered a successful controlled release oral cefaclor dosage form.</description><identifier>ISSN: 1330-0075</identifier><identifier>EISSN: 1846-9558</identifier><identifier>DOI: 10.2478/acph-2013-0003</identifier><identifier>PMID: 23482311</identifier><identifier>CODEN: ACPHEE</identifier><language>eng</language><publisher>Croatia: De Gruyter Poland</publisher><subject>Administration, Oral ; Alginates - chemistry ; Anti-Infective Agents - administration & dosage ; Anti-Infective Agents - chemistry ; cefaclor ; Cefaclor - administration & dosage ; Cefaclor - chemistry ; Chemistry, Pharmaceutical - methods ; Chitosan - chemistry ; chitosan-alginate ; Delayed-Action Preparations - chemistry ; Dosage Forms ; Drug Carriers - chemistry ; Drug Delivery Systems - methods ; Glucuronic Acid - chemistry ; Hexuronic Acids - chemistry ; Kinetics ; Klebsiella pneumoniae - drug effects ; modified release ; oral delivery ; Particle Size ; Polyethylene Glycols - chemistry ; shellac coated beads ; Solvents - chemistry ; Staphylococcus aureus - drug effects</subject><ispartof>Acta Pharmaceutica, 2013-03, Vol.63 (1), p.31-44</ispartof><rights>Copyright Versita Mar 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-3b411441d31e20148d8a364bdbbdbe708b15dd7cf24fcb8aed977da6c5d524a83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23482311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasool, Bazigha K Abdul</creatorcontrib><creatorcontrib>Fahmy, Sahar A</creatorcontrib><title>Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation</title><title>Acta Pharmaceutica</title><addtitle>Acta Pharm</addtitle><description>The aim of the present study was to develop and characterize coated chitosan-alginate beads containing cefaclor as a controlled release delivery system. Coated cefaclor beads were prepared by solvent evaporation techniques. Beads were found to be intact and spherical in shape. Their size range was 1.05 to 2.06. The loading efficiency showed maximum value when the concentration of cefaclor, chitosan and PEG 400 was 10 % (m/V), 0.5 % (m/V) and 2 % (V/V), respectively. Best retardation of cefaclor release from chitosan-alginate beads was achieved by coating with 15 % of shellac in formula F19. A significant antimicrobial activity (p < 0.05) against Staphylococcus aureus and Klebsiella pneumoniae was observed for formula F19 compared to the standard antibiotic disc. Furthermore, the simulated plasma profile showed the superiority of F19 in sustaining drug release for more than 12 h. Therefore, shellac coated chitosan-alginate beads could be considered a successful controlled release oral cefaclor dosage form.</description><subject>Administration, Oral</subject><subject>Alginates - chemistry</subject><subject>Anti-Infective Agents - administration & dosage</subject><subject>Anti-Infective Agents - chemistry</subject><subject>cefaclor</subject><subject>Cefaclor - administration & dosage</subject><subject>Cefaclor - chemistry</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Chitosan - chemistry</subject><subject>chitosan-alginate</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Dosage Forms</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems - methods</subject><subject>Glucuronic Acid - chemistry</subject><subject>Hexuronic Acids - chemistry</subject><subject>Kinetics</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>modified release</subject><subject>oral delivery</subject><subject>Particle Size</subject><subject>Polyethylene Glycols - chemistry</subject><subject>shellac coated beads</subject><subject>Solvents - chemistry</subject><subject>Staphylococcus aureus - drug effects</subject><issn>1330-0075</issn><issn>1846-9558</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkctLxDAQh4Morq-rRyl48WA1zybrTXyD4EUPnkKaTNmu2WZN2gX_e1NX9yAEMvzyZZjhQ-iY4AvKpbo0djkrKSasxBizLbRHFK_KqRBqO9eM4ZxLMUH7Kc0x5lIquosmlHFFGSF76P0WVuDDcgFdX4SmsMH04IoajEtFE2IRovE57foYvM8vDny7gvj1A0NjrA_xqnjqilWbkQJWxg-mb0N3iHYa4xMc_d4H6O3-7vXmsXx-eXi6uX4uLa-qvmQ1J4Rz4hiBvAdXThlW8drV-YDEqibCOWkbyhtbKwNuKqUzlRVOUG4UO0Dn676zaM2HXsZ2YeKXDqbV6yRFC7nU0woTmfGzNb6M4XOA1OtFmyx4bzoIQ9KEEcnxtKIjevoPnYchdnmZTFElBBYVztTFmrIxpBSh2YxAsB4d6dGRHh3p0VH-cPLbdqgX4Db4nxT2DUGRjaU</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Rasool, Bazigha K Abdul</creator><creator>Fahmy, Sahar A</creator><general>De Gruyter Poland</general><general>Hrvatsko farmaceutsko društvo</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>VP8</scope></search><sort><creationdate>20130301</creationdate><title>Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation</title><author>Rasool, Bazigha K Abdul ; Fahmy, Sahar A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-3b411441d31e20148d8a364bdbbdbe708b15dd7cf24fcb8aed977da6c5d524a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Oral</topic><topic>Alginates - chemistry</topic><topic>Anti-Infective Agents - administration & dosage</topic><topic>Anti-Infective Agents - chemistry</topic><topic>cefaclor</topic><topic>Cefaclor - administration & dosage</topic><topic>Cefaclor - chemistry</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Chitosan - chemistry</topic><topic>chitosan-alginate</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Dosage Forms</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems - methods</topic><topic>Glucuronic Acid - chemistry</topic><topic>Hexuronic Acids - chemistry</topic><topic>Kinetics</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>modified release</topic><topic>oral delivery</topic><topic>Particle Size</topic><topic>Polyethylene Glycols - chemistry</topic><topic>shellac coated beads</topic><topic>Solvents - chemistry</topic><topic>Staphylococcus aureus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasool, Bazigha K Abdul</creatorcontrib><creatorcontrib>Fahmy, Sahar A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hrcak: Portal of scientific journals of Croatia</collection><jtitle>Acta Pharmaceutica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasool, Bazigha K Abdul</au><au>Fahmy, Sahar A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation</atitle><jtitle>Acta Pharmaceutica</jtitle><addtitle>Acta Pharm</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>63</volume><issue>1</issue><spage>31</spage><epage>44</epage><pages>31-44</pages><issn>1330-0075</issn><eissn>1846-9558</eissn><coden>ACPHEE</coden><abstract>The aim of the present study was to develop and characterize coated chitosan-alginate beads containing cefaclor as a controlled release delivery system. Coated cefaclor beads were prepared by solvent evaporation techniques. Beads were found to be intact and spherical in shape. Their size range was 1.05 to 2.06. The loading efficiency showed maximum value when the concentration of cefaclor, chitosan and PEG 400 was 10 % (m/V), 0.5 % (m/V) and 2 % (V/V), respectively. Best retardation of cefaclor release from chitosan-alginate beads was achieved by coating with 15 % of shellac in formula F19. A significant antimicrobial activity (p < 0.05) against Staphylococcus aureus and Klebsiella pneumoniae was observed for formula F19 compared to the standard antibiotic disc. Furthermore, the simulated plasma profile showed the superiority of F19 in sustaining drug release for more than 12 h. Therefore, shellac coated chitosan-alginate beads could be considered a successful controlled release oral cefaclor dosage form.</abstract><cop>Croatia</cop><pub>De Gruyter Poland</pub><pmid>23482311</pmid><doi>10.2478/acph-2013-0003</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1330-0075 |
| ispartof | Acta Pharmaceutica, 2013-03, Vol.63 (1), p.31-44 |
| issn | 1330-0075 1846-9558 |
| language | eng |
| recordid | cdi_hrcak_primary_oai_hrcak_srce_hr_96017 |
| source | Open Access: DOAJ - Directory of Open Access Journals; MEDLINE; Walter De Gruyter: Open Access Journals; Free E-Journal (出版社公開部分のみ） |
| subjects | Administration, Oral Alginates - chemistry Anti-Infective Agents - administration & dosage Anti-Infective Agents - chemistry cefaclor Cefaclor - administration & dosage Cefaclor - chemistry Chemistry, Pharmaceutical - methods Chitosan - chemistry chitosan-alginate Delayed-Action Preparations - chemistry Dosage Forms Drug Carriers - chemistry Drug Delivery Systems - methods Glucuronic Acid - chemistry Hexuronic Acids - chemistry Kinetics Klebsiella pneumoniae - drug effects modified release oral delivery Particle Size Polyethylene Glycols - chemistry shellac coated beads Solvents - chemistry Staphylococcus aureus - drug effects |
| title | Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T08%3A19%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hrcak&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20coated%20beads%20for%20oral%20controlled%20delivery%20of%20cefaclor:%20In%20vitro%20evaluation&rft.jtitle=Acta%20Pharmaceutica&rft.au=Rasool,%20Bazigha%20K%20Abdul&rft.date=2013-03-01&rft.volume=63&rft.issue=1&rft.spage=31&rft.epage=44&rft.pages=31-44&rft.issn=1330-0075&rft.eissn=1846-9558&rft.coden=ACPHEE&rft_id=info:doi/10.2478/acph-2013-0003&rft_dat=%3Cproquest_hrcak%3E2948707141%3C/proquest_hrcak%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1328550560&rft_id=info:pmid/23482311&rfr_iscdi=true |