Heterociklički derivati 3-(4-bromfenil) azo-5-fenil-2(3H)-furanona: Djelovanje na virus ptičje gripe (H5N1)
3-[2-(4-Bromfenil)hidrazono]-5-fenil-furan-2(3H)-on (1) upotrjebljen je za pripravu novih derivata pirazola, piridazinona, oksadiazola, triazola, tiazolidina i tioksopirimidina. Neki od sintetiziranih spojeva imaju virustatski učinak na virus ptičje gripe H5N1. Farmakološki aktivnim spojevima određe...
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| Veröffentlicht in: | Acta Pharmaceutica 2012, Vol.62 (4), p.593 |
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| container_title | Acta Pharmaceutica |
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| creator | FLEFEL, EMAN M. ABDEL-MAGEID, RANDA E. TANTAWY, WALED A. ALI, MOHAMED A. AMR, ABD EL-GALIL E. |
| description | 3-[2-(4-Bromfenil)hidrazono]-5-fenil-furan-2(3H)-on (1) upotrjebljen je za pripravu novih derivata pirazola, piridazinona, oksadiazola, triazola, tiazolidina i tioksopirimidina. Neki od sintetiziranih spojeva imaju virustatski učinak na virus ptičje gripe H5N1. Farmakološki aktivnim spojevima određeni su EC50 i LD50 i dobiven je pozitivni test redukcije plaka na MDCK staničnoj liniji. Najjači učinak pokazali su 3-[2-(4-bromfenil)hidrazono]-5-fenilfuran-2(3H)-on (1), 1-(4-bromfenil)-N-hidroksi-5-fenil-1H-pirazol-3-karboksamid (5) i 1-(4-bromfenil)-N-{2,3-dihidro-4-hidroksi-3-fenil-6-okso-2-tioksopirimidin-1(6H)-il}-5-fenil-1H-pirazol-3-karboksamid (12a). Detaljno su opisani priprava, spektroskopski podaci i antivirusno djelovanje sintetiziranih spojeva. |
| doi_str_mv | 10.2478/v10007-012-0037-7 |
| format | Web Resource |
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Neki od sintetiziranih spojeva imaju virustatski učinak na virus ptičje gripe H5N1. Farmakološki aktivnim spojevima određeni su EC50 i LD50 i dobiven je pozitivni test redukcije plaka na MDCK staničnoj liniji. Najjači učinak pokazali su 3-[2-(4-bromfenil)hidrazono]-5-fenilfuran-2(3H)-on (1), 1-(4-bromfenil)-N-hidroksi-5-fenil-1H-pirazol-3-karboksamid (5) i 1-(4-bromfenil)-N-{2,3-dihidro-4-hidroksi-3-fenil-6-okso-2-tioksopirimidin-1(6H)-il}-5-fenil-1H-pirazol-3-karboksamid (12a). Detaljno su opisani priprava, spektroskopski podaci i antivirusno djelovanje sintetiziranih spojeva.</description><identifier>ISSN: 1330-0075</identifier><identifier>EISSN: 1846-9558</identifier><identifier>DOI: 10.2478/v10007-012-0037-7</identifier><identifier>CODEN: ACPHEE</identifier><language>hrv ; eng</language><publisher>Hrvatsko farmaceutsko društvo</publisher><subject>anti-avian influenza virus (H5N1) ; furanon ; furanone ; oksadiazol ; oxadiazole ; pirazol ; piridazinon ; pyrazole ; pyridazinone ; triazol ; triazole ; virus ptičje gripe (H5N1) ; virustatski učinak</subject><ispartof>Acta Pharmaceutica, 2012, Vol.62 (4), p.593</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,784,864,885,27916</link.rule.ids></links><search><creatorcontrib>FLEFEL, EMAN M.</creatorcontrib><creatorcontrib>ABDEL-MAGEID, RANDA E.</creatorcontrib><creatorcontrib>TANTAWY, WALED A.</creatorcontrib><creatorcontrib>ALI, MOHAMED A.</creatorcontrib><creatorcontrib>AMR, ABD EL-GALIL E.</creatorcontrib><title>Heterociklički derivati 3-(4-bromfenil) azo-5-fenil-2(3H)-furanona: Djelovanje na virus ptičje gripe (H5N1)</title><title>Acta Pharmaceutica</title><description>3-[2-(4-Bromfenil)hidrazono]-5-fenil-furan-2(3H)-on (1) upotrjebljen je za pripravu novih derivata pirazola, piridazinona, oksadiazola, triazola, tiazolidina i tioksopirimidina. Neki od sintetiziranih spojeva imaju virustatski učinak na virus ptičje gripe H5N1. Farmakološki aktivnim spojevima određeni su EC50 i LD50 i dobiven je pozitivni test redukcije plaka na MDCK staničnoj liniji. Najjači učinak pokazali su 3-[2-(4-bromfenil)hidrazono]-5-fenilfuran-2(3H)-on (1), 1-(4-bromfenil)-N-hidroksi-5-fenil-1H-pirazol-3-karboksamid (5) i 1-(4-bromfenil)-N-{2,3-dihidro-4-hidroksi-3-fenil-6-okso-2-tioksopirimidin-1(6H)-il}-5-fenil-1H-pirazol-3-karboksamid (12a). 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Neki od sintetiziranih spojeva imaju virustatski učinak na virus ptičje gripe H5N1. Farmakološki aktivnim spojevima određeni su EC50 i LD50 i dobiven je pozitivni test redukcije plaka na MDCK staničnoj liniji. Najjači učinak pokazali su 3-[2-(4-bromfenil)hidrazono]-5-fenilfuran-2(3H)-on (1), 1-(4-bromfenil)-N-hidroksi-5-fenil-1H-pirazol-3-karboksamid (5) i 1-(4-bromfenil)-N-{2,3-dihidro-4-hidroksi-3-fenil-6-okso-2-tioksopirimidin-1(6H)-il}-5-fenil-1H-pirazol-3-karboksamid (12a). Detaljno su opisani priprava, spektroskopski podaci i antivirusno djelovanje sintetiziranih spojeva.</abstract><pub>Hrvatsko farmaceutsko društvo</pub><doi>10.2478/v10007-012-0037-7</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1330-0075 |
| ispartof | Acta Pharmaceutica, 2012, Vol.62 (4), p.593 |
| issn | 1330-0075 1846-9558 |
| language | hrv ; eng |
| recordid | cdi_hrcak_primary_oai_hrcak_srce_hr_87233 |
| source | De Gruyter Open Access Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | anti-avian influenza virus (H5N1) furanon furanone oksadiazol oxadiazole pirazol piridazinon pyrazole pyridazinone triazol triazole virus ptičje gripe (H5N1) virustatski učinak |
| title | Heterociklički derivati 3-(4-bromfenil) azo-5-fenil-2(3H)-furanona: Djelovanje na virus ptičje gripe (H5N1) |
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