Potential Protective Role of SDF-1 and CXCR4 Gene Variants in the Development of Dementia
The aim of this study was to evaluate the role of polymorphisms of stromal cell-derived factor-1 (SDF-1) and chemokine receptor-4 (CXCR4) genes in dementia susceptibility in a Turkish population. The study group included 61 dementia patients, while the control group comprised 82 healthy individuals....
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| Veröffentlicht in: | Psychiatria Danubina 2020-01, Vol.32 (1), p.92-96 |
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| creator | Dalan, Burak Timirci-Kahraman, Ozlem Gulec-Yilmaz, Seda Altinkilic, Emre Murat Duman, Selvi Ayhan, Huseyin Isbir, Turgay |
| description | The aim of this study was to evaluate the role of polymorphisms of stromal cell-derived factor-1 (SDF-1) and chemokine receptor-4 (CXCR4) genes in dementia susceptibility in a Turkish population.
The study group included 61 dementia patients, while the control group comprised 82 healthy individuals. Gene polymorphisms of SDF-1 3'A G801A (rs1801157) and CXCR4 C138T (rs2228014) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
A significantly reduced risk for developing dementia was found for the group bearing an A allele for SDF-1 3'A polymorphism (p=0.009; χ
=6.812; OR=0.626; 95%CI= 0.429-0.913). The frequency of the CXCR4 TT and TC genotype was significantly lower in patients with dementia compared to controls (p=0.028; χ
=5.583; OR=0.215; 95%CI=0.05-0.914); (p=0.027; χ
=4.919; OR=0.484; 95% CI=0.246-0.955). Additionally, combined genotype analysis showed that the frequency of SDF1 GA-CXCR4 CC was significantly lower in patients with dementia in comparison with those of controls (p=0.049; OR=0.560; 95% CI= 0.307±1.020).
Our study provides new evidence that SDF1 A and CXCR4 T alleles may be associated with a decreased dementia risk. The present study is important because to our knowledge, it is the first one to be conducted in a Turkish population to date, but we believe that more patients and controls are needed to obtain statistically significant results. |
| doi_str_mv | 10.24869/psyd.2020.92 |
| format | Article |
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The study group included 61 dementia patients, while the control group comprised 82 healthy individuals. Gene polymorphisms of SDF-1 3'A G801A (rs1801157) and CXCR4 C138T (rs2228014) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
A significantly reduced risk for developing dementia was found for the group bearing an A allele for SDF-1 3'A polymorphism (p=0.009; χ
=6.812; OR=0.626; 95%CI= 0.429-0.913). The frequency of the CXCR4 TT and TC genotype was significantly lower in patients with dementia compared to controls (p=0.028; χ
=5.583; OR=0.215; 95%CI=0.05-0.914); (p=0.027; χ
=4.919; OR=0.484; 95% CI=0.246-0.955). Additionally, combined genotype analysis showed that the frequency of SDF1 GA-CXCR4 CC was significantly lower in patients with dementia in comparison with those of controls (p=0.049; OR=0.560; 95% CI= 0.307±1.020).
Our study provides new evidence that SDF1 A and CXCR4 T alleles may be associated with a decreased dementia risk. The present study is important because to our knowledge, it is the first one to be conducted in a Turkish population to date, but we believe that more patients and controls are needed to obtain statistically significant results.</description><identifier>ISSN: 0353-5053</identifier><identifier>EISSN: 1849-0867</identifier><identifier>DOI: 10.24869/psyd.2020.92</identifier><identifier>PMID: 32303038</identifier><language>eng</language><publisher>Croatia: Medicinska naklada</publisher><subject>Aged ; Alleles ; Chemokine CXCL12 - genetics ; CXCR4 ; dementia ; Dementia - genetics ; Female ; Genetic Predisposition to Disease - genetics ; Humans ; Male ; Polymorphism, Genetic ; Protective Factors ; Receptors, CXCR4 - genetics ; SDF-1 ; Turkey</subject><ispartof>Psychiatria Danubina, 2020-01, Vol.32 (1), p.92-96</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-de758e7b67a52a433bff6682016e0b350d63f81fef051d5dad3f9f0a519161813</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://hrcak.srce.hr/logo_broj/18865.jpg</thumbnail><link.rule.ids>230,315,781,785,886,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32303038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dalan, Burak</creatorcontrib><creatorcontrib>Timirci-Kahraman, Ozlem</creatorcontrib><creatorcontrib>Gulec-Yilmaz, Seda</creatorcontrib><creatorcontrib>Altinkilic, Emre Murat</creatorcontrib><creatorcontrib>Duman, Selvi</creatorcontrib><creatorcontrib>Ayhan, Huseyin</creatorcontrib><creatorcontrib>Isbir, Turgay</creatorcontrib><creatorcontrib>Istanbul University, Aziz Sancar DETAE, Istanbul, Turkey</creatorcontrib><creatorcontrib>Yeditepe University, Istanbul, Turkey</creatorcontrib><creatorcontrib>Yeditepe University, Institute of Health Science, Istanbul Turkey</creatorcontrib><title>Potential Protective Role of SDF-1 and CXCR4 Gene Variants in the Development of Dementia</title><title>Psychiatria Danubina</title><addtitle>Psychiatr Danub</addtitle><description>The aim of this study was to evaluate the role of polymorphisms of stromal cell-derived factor-1 (SDF-1) and chemokine receptor-4 (CXCR4) genes in dementia susceptibility in a Turkish population.
The study group included 61 dementia patients, while the control group comprised 82 healthy individuals. Gene polymorphisms of SDF-1 3'A G801A (rs1801157) and CXCR4 C138T (rs2228014) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
A significantly reduced risk for developing dementia was found for the group bearing an A allele for SDF-1 3'A polymorphism (p=0.009; χ
=6.812; OR=0.626; 95%CI= 0.429-0.913). The frequency of the CXCR4 TT and TC genotype was significantly lower in patients with dementia compared to controls (p=0.028; χ
=5.583; OR=0.215; 95%CI=0.05-0.914); (p=0.027; χ
=4.919; OR=0.484; 95% CI=0.246-0.955). Additionally, combined genotype analysis showed that the frequency of SDF1 GA-CXCR4 CC was significantly lower in patients with dementia in comparison with those of controls (p=0.049; OR=0.560; 95% CI= 0.307±1.020).
Our study provides new evidence that SDF1 A and CXCR4 T alleles may be associated with a decreased dementia risk. The present study is important because to our knowledge, it is the first one to be conducted in a Turkish population to date, but we believe that more patients and controls are needed to obtain statistically significant results.</description><subject>Aged</subject><subject>Alleles</subject><subject>Chemokine CXCL12 - genetics</subject><subject>CXCR4</subject><subject>dementia</subject><subject>Dementia - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Polymorphism, Genetic</subject><subject>Protective Factors</subject><subject>Receptors, CXCR4 - genetics</subject><subject>SDF-1</subject><subject>Turkey</subject><issn>0353-5053</issn><issn>1849-0867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtLAzEQh4MoWh9Hr5Kjl62TpMkmR2ltFQoWX-gppLsTXN1HTbZC_3u3tlbmMMPwzTfwI-ScQZ8PtDJXi7jK-xw49A3fIz2mByYBrdJ90gMhRSJBiiNyHOMHgNIA4pAcCS6gK90jb7OmxbotXElnoRuztvhG-tCUSBtPH0fjhFFX53T4OnwY0AnWSF9cKFzdRlrUtH1HOsJvLJtF1WnWNyOsfoWn5MC7MuLZtp-Q5_HN0_A2md5P7obX0yQTKbRJjqnUmM5V6iR3AyHm3iulOTCFMBcSciW8Zh49SJbL3OXCGw9OMsMU00yckGTjfQ-Z-7SLUFQurGzjCrvZxJBhN1re_VOi4y83_CI0X0uMra2KmGFZuhqbZewww4wGo_S_OgtNjAH9zs7A_qZv1-nbdfrW8I6_2KqX8wrzHf0Xt_gBil5_Dw</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Dalan, Burak</creator><creator>Timirci-Kahraman, Ozlem</creator><creator>Gulec-Yilmaz, Seda</creator><creator>Altinkilic, Emre Murat</creator><creator>Duman, Selvi</creator><creator>Ayhan, Huseyin</creator><creator>Isbir, Turgay</creator><general>Medicinska naklada</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>VP8</scope></search><sort><creationdate>20200101</creationdate><title>Potential Protective Role of SDF-1 and CXCR4 Gene Variants in the Development of Dementia</title><author>Dalan, Burak ; Timirci-Kahraman, Ozlem ; Gulec-Yilmaz, Seda ; Altinkilic, Emre Murat ; Duman, Selvi ; Ayhan, Huseyin ; Isbir, Turgay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-de758e7b67a52a433bff6682016e0b350d63f81fef051d5dad3f9f0a519161813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Chemokine CXCL12 - genetics</topic><topic>CXCR4</topic><topic>dementia</topic><topic>Dementia - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Polymorphism, Genetic</topic><topic>Protective Factors</topic><topic>Receptors, CXCR4 - genetics</topic><topic>SDF-1</topic><topic>Turkey</topic><toplevel>online_resources</toplevel><creatorcontrib>Dalan, Burak</creatorcontrib><creatorcontrib>Timirci-Kahraman, Ozlem</creatorcontrib><creatorcontrib>Gulec-Yilmaz, Seda</creatorcontrib><creatorcontrib>Altinkilic, Emre Murat</creatorcontrib><creatorcontrib>Duman, Selvi</creatorcontrib><creatorcontrib>Ayhan, Huseyin</creatorcontrib><creatorcontrib>Isbir, Turgay</creatorcontrib><creatorcontrib>Istanbul University, Aziz Sancar DETAE, Istanbul, Turkey</creatorcontrib><creatorcontrib>Yeditepe University, Istanbul, Turkey</creatorcontrib><creatorcontrib>Yeditepe University, Institute of Health Science, Istanbul Turkey</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hrcak: Portal of scientific journals of Croatia</collection><jtitle>Psychiatria Danubina</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dalan, Burak</au><au>Timirci-Kahraman, Ozlem</au><au>Gulec-Yilmaz, Seda</au><au>Altinkilic, Emre Murat</au><au>Duman, Selvi</au><au>Ayhan, Huseyin</au><au>Isbir, Turgay</au><aucorp>Istanbul University, Aziz Sancar DETAE, Istanbul, Turkey</aucorp><aucorp>Yeditepe University, Istanbul, Turkey</aucorp><aucorp>Yeditepe University, Institute of Health Science, Istanbul Turkey</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential Protective Role of SDF-1 and CXCR4 Gene Variants in the Development of Dementia</atitle><jtitle>Psychiatria Danubina</jtitle><addtitle>Psychiatr Danub</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>32</volume><issue>1</issue><spage>92</spage><epage>96</epage><pages>92-96</pages><issn>0353-5053</issn><eissn>1849-0867</eissn><abstract>The aim of this study was to evaluate the role of polymorphisms of stromal cell-derived factor-1 (SDF-1) and chemokine receptor-4 (CXCR4) genes in dementia susceptibility in a Turkish population.
The study group included 61 dementia patients, while the control group comprised 82 healthy individuals. Gene polymorphisms of SDF-1 3'A G801A (rs1801157) and CXCR4 C138T (rs2228014) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
A significantly reduced risk for developing dementia was found for the group bearing an A allele for SDF-1 3'A polymorphism (p=0.009; χ
=6.812; OR=0.626; 95%CI= 0.429-0.913). The frequency of the CXCR4 TT and TC genotype was significantly lower in patients with dementia compared to controls (p=0.028; χ
=5.583; OR=0.215; 95%CI=0.05-0.914); (p=0.027; χ
=4.919; OR=0.484; 95% CI=0.246-0.955). Additionally, combined genotype analysis showed that the frequency of SDF1 GA-CXCR4 CC was significantly lower in patients with dementia in comparison with those of controls (p=0.049; OR=0.560; 95% CI= 0.307±1.020).
Our study provides new evidence that SDF1 A and CXCR4 T alleles may be associated with a decreased dementia risk. The present study is important because to our knowledge, it is the first one to be conducted in a Turkish population to date, but we believe that more patients and controls are needed to obtain statistically significant results.</abstract><cop>Croatia</cop><pub>Medicinska naklada</pub><pmid>32303038</pmid><doi>10.24869/psyd.2020.92</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Psychiatria Danubina, 2020-01, Vol.32 (1), p.92-96 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Alleles Chemokine CXCL12 - genetics CXCR4 dementia Dementia - genetics Female Genetic Predisposition to Disease - genetics Humans Male Polymorphism, Genetic Protective Factors Receptors, CXCR4 - genetics SDF-1 Turkey |
| title | Potential Protective Role of SDF-1 and CXCR4 Gene Variants in the Development of Dementia |
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