1,2-Αnnulated Adamantane Heterocyclic Derivatives as Anti-Influenza Α Virus Agents

In this report we review our results on the development of 1,2-annulated adamantane heterocyclic derivatives and we discuss the structure-activity relationships obtained from their biological evaluation against influenza A virus. We have designed and synthesized numerous potent 1,2-annulated adamant...

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Veröffentlicht in:	Croatica Chemica Acta 2019, Vol.92 (2), p.211-228
Hauptverfasser:	Pardali, Vasiliki, Giannakopoulou, Erofili, Konstantinidi, Athina, Kolocouris, Antonios, Zoidis, Grigoris
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Annulated adamantane derivatives Acetic acid Acids Amantadine Anti-influenza A virus agents Choline Derivatives Genomes Glycoproteins H1N1 H3N2 Infections Influenza M2 protein Molecular dynamics Mortality Pandemics POPC hydrated bilayers Propionic acid Proteins Rimantadine RNA polymerase SAR Viral infections Viruses
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