Pentadecapeptide BPC 157 counteracts portal hypertension, caval hypertension and aortal hypotension with suprahepatic occlusion of inferior caval vein in rats

Portal hypertension, aortal hypotension, caval hypertension

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Veröffentlicht in:	Liječnički vjesnik 2019, Vol.141 (suppl.1)
Hauptverfasser:	Gojković, Slaven, Vraneš, Hrvoje, Jelovečki – Dokić, Zoya, Marcel Koltay, Oliver, Migo, Will, Malekinušić, Dominik
Format:	Web Resource
Sprache:	eng
Schlagworte:	and arterial hypotension and most importantly and thereby as an abdominal bath or as an intragastric application at 24 h or 48 h of ligation time. Medication (BPC 157) at 24 h or 48 h reperfusion time. Assessment of portal caval and aortal pressure showed huge portal hypertension and more caval hypertension along with mild aortic hypotension. Contrarily counteracts portal hypertension and caval hypotension. In deeply anesthetized and laparatomized rats that have suprahepatic occlusion of ICV even elevated in comparison to portal hypertension in rats with portal triad obstruction BPC 157 beneficially increased vessels branching in the intestinal serosa and counteracted intestinal lesions. It also counteracts free radical formation inferior caval vein and abdominal aorta at the level of bifurcation inserted into the portal vein may be a consistent therapy solution or saline (controls)) was applied in rats with suprahepatic occlusion of ICV spontaneous decompression of the portal system can hardly be expected by a portocaval shunt. BPC 157 suprahepatic ICV occlusion provides high caval hypertension the recording lasted 5 minutes with a cannula (assessed in one minute intervals) connected to a pressure transducer these disturbances were marked counteracted. Thus We introduce pentadecapeptide BPC 157 as the therapy of the hemodynamic disturbances in the prolonged suprahepatic occlusion of inferior caval vein (ICV) in rats mimicking Budd-Chiari syndrome. Previously when BPC 157 was given in those circumstances of the portal and caval hypertension
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