Detection of IgG Autoantibodies against Desmocollin-3 in Greek Patients with Pemphigus
Pemphigus is an autoimmune bullous disorder caused by autoantibodies against desmosomal cadherins. The most common clinical forms are pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Among the numerous proteins that are considered responsible for the cohesion of keratinocytes in epidermis, desm...
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| Veröffentlicht in: | Acta dermatovenerologica Croatica 2019-03, Vol.27 (1), p.8-10 |
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| container_title | Acta dermatovenerologica Croatica |
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| creator | Meltzanidou, Parthena Patsatsi, Aikaterini Kyriakou, Aikaterini Vareli, Katerina Lambropoulos, Alexandros |
| description | Pemphigus is an autoimmune bullous disorder caused by autoantibodies against desmosomal cadherins. The most common clinical forms are pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Among the numerous proteins that are considered responsible for the cohesion of keratinocytes in epidermis, desmocollin-3 (Dsc-3) has been initially reported to participate in epidermal blistering in mice. There have been reports in which autoantibodies against Dsc-3 have been detected. In PV, a limited number of studies found no presence of IgG or IgA autoantibodies against Dsc-3. In this study we examined sera from Greek patients with PV and PF for the presence of IgG autoantibodies against Dsc-3. Immunoblotting for the detection of autoantibodies against Dsc-3 was performed in sera from all cases. Dsc-3 autoantibodies were not detected in either group (PV and PF). Our results confirm the hypothesis that the pathogenic role of Dsc-3 in epidermal blistering in PV and PF remains controversial. |
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The most common clinical forms are pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Among the numerous proteins that are considered responsible for the cohesion of keratinocytes in epidermis, desmocollin-3 (Dsc-3) has been initially reported to participate in epidermal blistering in mice. There have been reports in which autoantibodies against Dsc-3 have been detected. In PV, a limited number of studies found no presence of IgG or IgA autoantibodies against Dsc-3. In this study we examined sera from Greek patients with PV and PF for the presence of IgG autoantibodies against Dsc-3. Immunoblotting for the detection of autoantibodies against Dsc-3 was performed in sera from all cases. Dsc-3 autoantibodies were not detected in either group (PV and PF). Our results confirm the hypothesis that the pathogenic role of Dsc-3 in epidermal blistering in PV and PF remains controversial.</description><identifier>ISSN: 1330-027X</identifier><identifier>EISSN: 1847-6538</identifier><identifier>PMID: 31032784</identifier><language>eng</language><publisher>Croatia: Acta Dermatovenerologica Croatica</publisher><subject>Autoantibodies - blood ; Case-Control Studies ; Desmocollins - immunology ; Greece ; Humans ; Immunoglobulin G - blood ; Pemphigus - blood ; Pemphigus - immunology</subject><ispartof>Acta dermatovenerologica Croatica, 2019-03, Vol.27 (1), p.8-10</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-7594-8512 ; 0000-0001-9616-2001</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31032784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meltzanidou, Parthena</creatorcontrib><creatorcontrib>Patsatsi, Aikaterini</creatorcontrib><creatorcontrib>Kyriakou, Aikaterini</creatorcontrib><creatorcontrib>Vareli, Katerina</creatorcontrib><creatorcontrib>Lambropoulos, Alexandros</creatorcontrib><title>Detection of IgG Autoantibodies against Desmocollin-3 in Greek Patients with Pemphigus</title><title>Acta dermatovenerologica Croatica</title><addtitle>Acta Dermatovenerol Croat</addtitle><description>Pemphigus is an autoimmune bullous disorder caused by autoantibodies against desmosomal cadherins. The most common clinical forms are pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Among the numerous proteins that are considered responsible for the cohesion of keratinocytes in epidermis, desmocollin-3 (Dsc-3) has been initially reported to participate in epidermal blistering in mice. There have been reports in which autoantibodies against Dsc-3 have been detected. In PV, a limited number of studies found no presence of IgG or IgA autoantibodies against Dsc-3. In this study we examined sera from Greek patients with PV and PF for the presence of IgG autoantibodies against Dsc-3. Immunoblotting for the detection of autoantibodies against Dsc-3 was performed in sera from all cases. Dsc-3 autoantibodies were not detected in either group (PV and PF). Our results confirm the hypothesis that the pathogenic role of Dsc-3 in epidermal blistering in PV and PF remains controversial.</description><subject>Autoantibodies - blood</subject><subject>Case-Control Studies</subject><subject>Desmocollins - immunology</subject><subject>Greece</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Pemphigus - blood</subject><subject>Pemphigus - immunology</subject><issn>1330-027X</issn><issn>1847-6538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90EFLwzAUB_AiipvTryA5eimkSZukx7HpNhi4g4q3kqQva1ybzCZF_PZWNj29P48ffx7vIplmIucpK6i4HDOlOMWEv0-SmxA-MGaCk-w6mdAMU8JFPk3elhBBR-sd8gZt9is0H6KXLlrlawsByb20LkS0hNB57dvWupQi69CqBzignYwWXAzoy8YG7aA7NnY_hNvkysg2wN15zpLXp8eXxTrdPq82i_k2bUhexlQpPp5IioIaledUMElyU7NCE80U1jSrR6bLslSGaCNIjpUA0KqmCowmhM6S9NTb9FoeqmNvO9l_V17a6rQJvYYxViQrC_HrH07-2PvPAUKsOhs0tK104IdQEZIxzjHL-Ejvz3RQHdT_3X-_oz8u6mxb</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Meltzanidou, Parthena</creator><creator>Patsatsi, Aikaterini</creator><creator>Kyriakou, Aikaterini</creator><creator>Vareli, Katerina</creator><creator>Lambropoulos, Alexandros</creator><general>Acta Dermatovenerologica Croatica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>VP8</scope><orcidid>https://orcid.org/0000-0002-7594-8512</orcidid><orcidid>https://orcid.org/0000-0001-9616-2001</orcidid></search><sort><creationdate>201903</creationdate><title>Detection of IgG Autoantibodies against Desmocollin-3 in Greek Patients with Pemphigus</title><author>Meltzanidou, Parthena ; Patsatsi, Aikaterini ; Kyriakou, Aikaterini ; Vareli, Katerina ; Lambropoulos, Alexandros</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h249t-bb73302553fb44386a24fd65c2c6b0c31d249c999bf2cf8240b8eecbd3befc223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Autoantibodies - blood</topic><topic>Case-Control Studies</topic><topic>Desmocollins - immunology</topic><topic>Greece</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Pemphigus - blood</topic><topic>Pemphigus - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meltzanidou, Parthena</creatorcontrib><creatorcontrib>Patsatsi, Aikaterini</creatorcontrib><creatorcontrib>Kyriakou, Aikaterini</creatorcontrib><creatorcontrib>Vareli, Katerina</creatorcontrib><creatorcontrib>Lambropoulos, Alexandros</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Hrcak: Portal of scientific journals of Croatia</collection><jtitle>Acta dermatovenerologica Croatica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meltzanidou, Parthena</au><au>Patsatsi, Aikaterini</au><au>Kyriakou, Aikaterini</au><au>Vareli, Katerina</au><au>Lambropoulos, Alexandros</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of IgG Autoantibodies against Desmocollin-3 in Greek Patients with Pemphigus</atitle><jtitle>Acta dermatovenerologica Croatica</jtitle><addtitle>Acta Dermatovenerol Croat</addtitle><date>2019-03</date><risdate>2019</risdate><volume>27</volume><issue>1</issue><spage>8</spage><epage>10</epage><pages>8-10</pages><issn>1330-027X</issn><eissn>1847-6538</eissn><abstract>Pemphigus is an autoimmune bullous disorder caused by autoantibodies against desmosomal cadherins. The most common clinical forms are pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Among the numerous proteins that are considered responsible for the cohesion of keratinocytes in epidermis, desmocollin-3 (Dsc-3) has been initially reported to participate in epidermal blistering in mice. There have been reports in which autoantibodies against Dsc-3 have been detected. In PV, a limited number of studies found no presence of IgG or IgA autoantibodies against Dsc-3. In this study we examined sera from Greek patients with PV and PF for the presence of IgG autoantibodies against Dsc-3. Immunoblotting for the detection of autoantibodies against Dsc-3 was performed in sera from all cases. Dsc-3 autoantibodies were not detected in either group (PV and PF). Our results confirm the hypothesis that the pathogenic role of Dsc-3 in epidermal blistering in PV and PF remains controversial.</abstract><cop>Croatia</cop><pub>Acta Dermatovenerologica Croatica</pub><pmid>31032784</pmid><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-7594-8512</orcidid><orcidid>https://orcid.org/0000-0001-9616-2001</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta dermatovenerologica Croatica, 2019-03, Vol.27 (1), p.8-10 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Autoantibodies - blood Case-Control Studies Desmocollins - immunology Greece Humans Immunoglobulin G - blood Pemphigus - blood Pemphigus - immunology |
| title | Detection of IgG Autoantibodies against Desmocollin-3 in Greek Patients with Pemphigus |
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