Association of Low Molecular Weight Plasma Aminothiols with the Severity of Coronavirus Disease 2019

Association of Low Molecular Weight Plasma Aminothiols with the Severity of Coronavirus Disease 2019

Objective. Aminothiols (glutathione (GSH), cysteinylglycine (CG)) may play an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), but the possible association of these indicators with the severity of COVID-19 has not yet been investigated. Methods. The total content (t) and re...

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Veröffentlicht in:Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.9221693-9221693, Article 9221693
Hauptverfasser: Kryukov, Evgeny Vladimirovich, Ivanov, Alexander Vladimirovich, Karpov, Vladimir Olegovich, Vasil’evich Alexandrin, Valery, Dygai, Alexander Mikhaylovich, Kruglova, Maria Petrovna, Kostiuchenko, Gennady Ivanovich, Kazakov, Sergei Petrovich, Kubatiev, Aslan Amirkhanovich
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Advanced Oxidation Protein Products - blood
Aged
Amino Acids, Sulfur - blood
Biomarkers - blood
Cell Biology
Chromatography
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - diagnosis
COVID-19 - pathology
Dipeptides - blood
Dipeptides - metabolism
Disease
Female
Gene expression
Glutathione - blood
Glutathione - metabolism
Homocysteine
Humans
Infections
Laboratories
Life Sciences & Biomedicine
Lung - diagnostic imaging
Lung - pathology
Male
Middle Aged
Molecular weight
Oxidation-Reduction
Oxidative stress
Plasma
Proteins
SARS-CoV-2 - isolation & purification
Science & Technology
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Software
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Zusammenfassung:Objective. Aminothiols (glutathione (GSH), cysteinylglycine (CG)) may play an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), but the possible association of these indicators with the severity of COVID-19 has not yet been investigated. Methods. The total content (t) and reduced forms (r) of aminothiols were determined in patients with COVID-19 (n=59) on admission. Lung injury was characterized by computed tomography (CT) findings in accordance with the CT0-4 classification. Results. Low tGSH level was associated with the risk of severe COVID-19 (tGSH≤1.5 μM, mild vs. moderate/severe: risk ratio RR=3.09, p=0.007) and degree of lung damage (tGSH≤1.8 μM, CT
ISSN:1942-0900
1942-0994
DOI:10.1155/2021/9221693