Roles of Tumor Necrosis Factor-α of the Estrous Cycle in Cattle: An In Vivo Study
We have suggested in a previous in vitro study that tumor necrosis factor-α (TNFα) plays a role in the initiation of luteolysis in cattle. The aim of the present study was to examine the influence of different doses of TNFα on the estrous cycle in cattle by observing the standing behavior and mea...
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| Veröffentlicht in: | Biology of reproduction 2003-12, Vol.69 (6), p.1907 |
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| container_issue | 6 |
| container_start_page | 1907 |
| container_title | Biology of reproduction |
| container_volume | 69 |
| creator | Dariusz J. Skarzynski Mamadou M. Bah Katarzyna M. Deptula Izabela Woclawek-Potocka Anna Korzekwa Masami Shibaya Wojciech Pilawski Kiyoshi Okuda |
| description | We have suggested in a previous in vitro study that tumor necrosis factor-α (TNFα) plays a role in the initiation of luteolysis
in cattle. The aim of the present study was to examine the influence of different doses of TNFα on the estrous cycle in cattle
by observing the standing behavior and measuring peripheral concentrations of progesterone (P4) during the estrous cycle.
Moreover, we evaluated the secretion of P4, oxytocin (OT), nitric oxide (NO), and luteolytic (prostaglandin F 2α [PGF 2α ] and leukotriene C 4 [LTC 4 ]) and luteotropic (PGE 2 ) metabolites of arachidonic acid in peripheral blood plasma as parameters of TNFα actions. Mature Holstein/Polish black and
white heifers (n = 36) were treated on Day 14 of the estrous cycle (Day 0 = estrus) by infusion into the aorta abdominalis
of saline (n = 8), an analogue of PGF 2α (cloprostenol, 100 μg; n = 3) or saline with TNFα at doses of 0.1 (n = 3), 1 (n = 8), 10 (n = 8), 25 (n = 3), or 50 μg (n
= 3) per animal. Peripheral blood samples were collected frequently before, during, and up to 4 h after TNFα treatment. After
Day 15 of the estrous cycle, blood was collected once daily until Day 22 following the first estrus. Lower doses of TNFα (0.1
and 1 μg) decreased the P4 level during the estrous cycle and consequently resulted in shortening of the estrous cycle (18.8
± 0.9 and 18.0 ± 0.7 days, respectively) compared with the control (22.3 ± 0.3 days, P < 0.05). One microgram of TNFα increased the PGF 2α ( P < 0.001) and NO ( P < 0.001) concentrations and decreased OT secretion ( P < 0.01). Higher doses of TNFα (10, 25, 50 μg) stimulated synthesis of P4 ( P < 0.001) and PGE 2 ( P < 0.001), inhibited LTC 4 secreton ( P < 0.05), and consequently resulted in prolongation of the estrous cycle (throughout 30 days, P < 0.05). Altogether, the results suggest that low concentrations of TNFα cause luteolysis, whereas high concentrations of
TNFα activate corpus luteum function and prolong the estrous cycle in cattle. |
| doi_str_mv | 10.1095/biolreprod.103.016212 |
| format | Article |
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in cattle. The aim of the present study was to examine the influence of different doses of TNFα on the estrous cycle in cattle
by observing the standing behavior and measuring peripheral concentrations of progesterone (P4) during the estrous cycle.
Moreover, we evaluated the secretion of P4, oxytocin (OT), nitric oxide (NO), and luteolytic (prostaglandin F 2α [PGF 2α ] and leukotriene C 4 [LTC 4 ]) and luteotropic (PGE 2 ) metabolites of arachidonic acid in peripheral blood plasma as parameters of TNFα actions. Mature Holstein/Polish black and
white heifers (n = 36) were treated on Day 14 of the estrous cycle (Day 0 = estrus) by infusion into the aorta abdominalis
of saline (n = 8), an analogue of PGF 2α (cloprostenol, 100 μg; n = 3) or saline with TNFα at doses of 0.1 (n = 3), 1 (n = 8), 10 (n = 8), 25 (n = 3), or 50 μg (n
= 3) per animal. Peripheral blood samples were collected frequently before, during, and up to 4 h after TNFα treatment. After
Day 15 of the estrous cycle, blood was collected once daily until Day 22 following the first estrus. Lower doses of TNFα (0.1
and 1 μg) decreased the P4 level during the estrous cycle and consequently resulted in shortening of the estrous cycle (18.8
± 0.9 and 18.0 ± 0.7 days, respectively) compared with the control (22.3 ± 0.3 days, P < 0.05). One microgram of TNFα increased the PGF 2α ( P < 0.001) and NO ( P < 0.001) concentrations and decreased OT secretion ( P < 0.01). Higher doses of TNFα (10, 25, 50 μg) stimulated synthesis of P4 ( P < 0.001) and PGE 2 ( P < 0.001), inhibited LTC 4 secreton ( P < 0.05), and consequently resulted in prolongation of the estrous cycle (throughout 30 days, P < 0.05). Altogether, the results suggest that low concentrations of TNFα cause luteolysis, whereas high concentrations of
TNFα activate corpus luteum function and prolong the estrous cycle in cattle.]]></description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod.103.016212</identifier><identifier>PMID: 12904309</identifier><language>eng</language><publisher>Society for the Study of Reproduction</publisher><ispartof>Biology of reproduction, 2003-12, Vol.69 (6), p.1907</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Dariusz J. Skarzynski</creatorcontrib><creatorcontrib>Mamadou M. Bah</creatorcontrib><creatorcontrib>Katarzyna M. Deptula</creatorcontrib><creatorcontrib>Izabela Woclawek-Potocka</creatorcontrib><creatorcontrib>Anna Korzekwa</creatorcontrib><creatorcontrib>Masami Shibaya</creatorcontrib><creatorcontrib>Wojciech Pilawski</creatorcontrib><creatorcontrib>Kiyoshi Okuda</creatorcontrib><title>Roles of Tumor Necrosis Factor-α of the Estrous Cycle in Cattle: An In Vivo Study</title><title>Biology of reproduction</title><description><![CDATA[We have suggested in a previous in vitro study that tumor necrosis factor-α (TNFα) plays a role in the initiation of luteolysis
in cattle. The aim of the present study was to examine the influence of different doses of TNFα on the estrous cycle in cattle
by observing the standing behavior and measuring peripheral concentrations of progesterone (P4) during the estrous cycle.
Moreover, we evaluated the secretion of P4, oxytocin (OT), nitric oxide (NO), and luteolytic (prostaglandin F 2α [PGF 2α ] and leukotriene C 4 [LTC 4 ]) and luteotropic (PGE 2 ) metabolites of arachidonic acid in peripheral blood plasma as parameters of TNFα actions. Mature Holstein/Polish black and
white heifers (n = 36) were treated on Day 14 of the estrous cycle (Day 0 = estrus) by infusion into the aorta abdominalis
of saline (n = 8), an analogue of PGF 2α (cloprostenol, 100 μg; n = 3) or saline with TNFα at doses of 0.1 (n = 3), 1 (n = 8), 10 (n = 8), 25 (n = 3), or 50 μg (n
= 3) per animal. Peripheral blood samples were collected frequently before, during, and up to 4 h after TNFα treatment. After
Day 15 of the estrous cycle, blood was collected once daily until Day 22 following the first estrus. Lower doses of TNFα (0.1
and 1 μg) decreased the P4 level during the estrous cycle and consequently resulted in shortening of the estrous cycle (18.8
± 0.9 and 18.0 ± 0.7 days, respectively) compared with the control (22.3 ± 0.3 days, P < 0.05). One microgram of TNFα increased the PGF 2α ( P < 0.001) and NO ( P < 0.001) concentrations and decreased OT secretion ( P < 0.01). Higher doses of TNFα (10, 25, 50 μg) stimulated synthesis of P4 ( P < 0.001) and PGE 2 ( P < 0.001), inhibited LTC 4 secreton ( P < 0.05), and consequently resulted in prolongation of the estrous cycle (throughout 30 days, P < 0.05). Altogether, the results suggest that low concentrations of TNFα cause luteolysis, whereas high concentrations of
TNFα activate corpus luteum function and prolong the estrous cycle in cattle.]]></description><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqNikFOwzAQAFcIRFPgCUh74pay9rYu5oaiVnDhUCKuUZq6xMiNK9sh6if4C1-AjwESD-A0Gs0AXAqaCNKz67X1Lph98Jsf5wkJJYU8gkzMpM7nUt0cQ0ZEKmdWPIJxjK9EYsqST2EkpKYpk86gXHlnIvotlv3OB3w0TfDRRlzWTfIh_3r__PitqTW4iCn4PmJxaJxB22FRp-TMLd51-NDhs33z-JT6zeEcTra1i-bij2dwtVyUxX3e2pd2sMFUcVc7t-_XXA3DoHSlKqFpzv8evwFT7E3z</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Dariusz J. Skarzynski</creator><creator>Mamadou M. Bah</creator><creator>Katarzyna M. Deptula</creator><creator>Izabela Woclawek-Potocka</creator><creator>Anna Korzekwa</creator><creator>Masami Shibaya</creator><creator>Wojciech Pilawski</creator><creator>Kiyoshi Okuda</creator><general>Society for the Study of Reproduction</general><scope/></search><sort><creationdate>20031201</creationdate><title>Roles of Tumor Necrosis Factor-α of the Estrous Cycle in Cattle: An In Vivo Study</title><author>Dariusz J. Skarzynski ; Mamadou M. Bah ; Katarzyna M. Deptula ; Izabela Woclawek-Potocka ; Anna Korzekwa ; Masami Shibaya ; Wojciech Pilawski ; Kiyoshi Okuda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-highwire_smallpub3_www69_6_19073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dariusz J. Skarzynski</creatorcontrib><creatorcontrib>Mamadou M. Bah</creatorcontrib><creatorcontrib>Katarzyna M. Deptula</creatorcontrib><creatorcontrib>Izabela Woclawek-Potocka</creatorcontrib><creatorcontrib>Anna Korzekwa</creatorcontrib><creatorcontrib>Masami Shibaya</creatorcontrib><creatorcontrib>Wojciech Pilawski</creatorcontrib><creatorcontrib>Kiyoshi Okuda</creatorcontrib><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dariusz J. Skarzynski</au><au>Mamadou M. Bah</au><au>Katarzyna M. Deptula</au><au>Izabela Woclawek-Potocka</au><au>Anna Korzekwa</au><au>Masami Shibaya</au><au>Wojciech Pilawski</au><au>Kiyoshi Okuda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roles of Tumor Necrosis Factor-α of the Estrous Cycle in Cattle: An In Vivo Study</atitle><jtitle>Biology of reproduction</jtitle><date>2003-12-01</date><risdate>2003</risdate><volume>69</volume><issue>6</issue><spage>1907</spage><pages>1907-</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><abstract><![CDATA[We have suggested in a previous in vitro study that tumor necrosis factor-α (TNFα) plays a role in the initiation of luteolysis
in cattle. The aim of the present study was to examine the influence of different doses of TNFα on the estrous cycle in cattle
by observing the standing behavior and measuring peripheral concentrations of progesterone (P4) during the estrous cycle.
Moreover, we evaluated the secretion of P4, oxytocin (OT), nitric oxide (NO), and luteolytic (prostaglandin F 2α [PGF 2α ] and leukotriene C 4 [LTC 4 ]) and luteotropic (PGE 2 ) metabolites of arachidonic acid in peripheral blood plasma as parameters of TNFα actions. Mature Holstein/Polish black and
white heifers (n = 36) were treated on Day 14 of the estrous cycle (Day 0 = estrus) by infusion into the aorta abdominalis
of saline (n = 8), an analogue of PGF 2α (cloprostenol, 100 μg; n = 3) or saline with TNFα at doses of 0.1 (n = 3), 1 (n = 8), 10 (n = 8), 25 (n = 3), or 50 μg (n
= 3) per animal. Peripheral blood samples were collected frequently before, during, and up to 4 h after TNFα treatment. After
Day 15 of the estrous cycle, blood was collected once daily until Day 22 following the first estrus. Lower doses of TNFα (0.1
and 1 μg) decreased the P4 level during the estrous cycle and consequently resulted in shortening of the estrous cycle (18.8
± 0.9 and 18.0 ± 0.7 days, respectively) compared with the control (22.3 ± 0.3 days, P < 0.05). One microgram of TNFα increased the PGF 2α ( P < 0.001) and NO ( P < 0.001) concentrations and decreased OT secretion ( P < 0.01). Higher doses of TNFα (10, 25, 50 μg) stimulated synthesis of P4 ( P < 0.001) and PGE 2 ( P < 0.001), inhibited LTC 4 secreton ( P < 0.05), and consequently resulted in prolongation of the estrous cycle (throughout 30 days, P < 0.05). Altogether, the results suggest that low concentrations of TNFα cause luteolysis, whereas high concentrations of
TNFα activate corpus luteum function and prolong the estrous cycle in cattle.]]></abstract><pub>Society for the Study of Reproduction</pub><pmid>12904309</pmid><doi>10.1095/biolreprod.103.016212</doi></addata></record> |
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| source | BioOne Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| title | Roles of Tumor Necrosis Factor-α of the Estrous Cycle in Cattle: An In Vivo Study |
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