DNA Double-Strand Breaks and γ-H2AX Signaling in the Testis
Within minutes of the induction of DNA double-strand breaks in somatic cells, histone H2AX becomes phosphorylated at serine 139 and forms γ-H2AX foci at the sites of damage. These foci then play a role in recruiting DNA repair and damage-response factors and changing chromatin structure to accurate...
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Veröffentlicht in: | Biology of reproduction 2003-02, Vol.68 (2), p.628 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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