Hepatocellular Carcinoma Associated with Membranous Obstruction of the Inferior Vena Cava: Incidence, Characteristics, and Risk Factors and Clinical Efficacy of TACE1
Purpose: To analyze the characteristics associated with membranous obstruction of the inferior vena cava (MOVC)âassociated hepatocellular carcinoma (HCC) and to evaluate the clinical efficacy of transcatheter arterial chemoembolization (TACE). Materials and Methods: This retrospective study was ap...
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| Veröffentlicht in: | Radiology 2010-02, Vol.254 (2), p.617 |
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| creator | Dong Gwon II Gi-Young Ko Hyun-Ki Yoon Kyu-Bo Sung Jin Hyoung Kim Seung Soo Lee Jae Myeong Lee Joon-Young Ohm Ji Hoon Shin Ho-Young Song |
| description | Purpose: To analyze the characteristics associated with membranous obstruction of the inferior vena cava (MOVC)âassociated hepatocellular
carcinoma (HCC) and to evaluate the clinical efficacy of transcatheter arterial chemoembolization (TACE).
Materials and Methods: This retrospective study was approved by an institutional review board, and informed consent was waived. Ninety-eight patients
(mean age, 48.5 years ± 12.9 [standard deviation]) with MOVC were retrospectively evaluated. The diagnosis of Budd-Chiari
syndrome was confirmed with results from Doppler ultrasonography, computed tomography, magnetic resonance imaging, and/or
inferior venacavography. The cumulative incidences of HCC and the patient survival period were calculated by using the Kaplan-Meier
method. Factors associated with the development of HCC were evaluated by using multivariate Cox regression analysis.
Results: Among 98 patients with MOVC, liver nodules were detected in 37 patients (38%), 23 of whom had HCC associated with MOVC and
14 of whom had benign nodules. The cumulative incidence of HCC at 1, 5, and 10 years was 7.3%, 13.5%, and 31.8%, respectively.
Female sex was the only significant factor associated with the development of HCC (odds ratio, 6.02; P |
| doi_str_mv | 10.1148/radiol.09090738 |
| format | Article |
| fullrecord | <record><control><sourceid>highwire</sourceid><recordid>TN_cdi_highwire_smallpub3_radiology254_2_617</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>radiology254_2_617</sourcerecordid><originalsourceid>FETCH-highwire_smallpub3_radiology254_2_6173</originalsourceid><addsrcrecordid>eNqVkMtKw0AYhQdRMF7Wbv8HSGomF5O6KyGlLkSQ4jb8mUyaXyczZWZi6Qv5nI2XF5CzOPDxcRaHsTseLzjPynuLHRm1iJdzirQ8YwHPkyLiKc_PWRDHaRqVGV9esivn3uOYZ3lZBOxrI_fojZBKTQotVGgFaTMirJwzgtDLDg7kB3iWY2tRm8nBS-u8nYQno8H04AcJT7qXloyFN6lxXvnEx5kJ6qQWMoRqQIvCz4rzJFwIqDt4JfcB6xkb635ApUiTQAV1388tjt_r21VV8xt20aNy8vavr1m4rrfVJhpoNxzIysaNqNR-atPm9wizOyZ51iTNAy_Sf-onDUVsbA</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Hepatocellular Carcinoma Associated with Membranous Obstruction of the Inferior Vena Cava: Incidence, Characteristics, and Risk Factors and Clinical Efficacy of TACE1</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Dong Gwon II ; Gi-Young Ko ; Hyun-Ki Yoon ; Kyu-Bo Sung ; Jin Hyoung Kim ; Seung Soo Lee ; Jae Myeong Lee ; Joon-Young Ohm ; Ji Hoon Shin ; Ho-Young Song</creator><creatorcontrib>Dong Gwon II ; Gi-Young Ko ; Hyun-Ki Yoon ; Kyu-Bo Sung ; Jin Hyoung Kim ; Seung Soo Lee ; Jae Myeong Lee ; Joon-Young Ohm ; Ji Hoon Shin ; Ho-Young Song</creatorcontrib><description>Purpose: To analyze the characteristics associated with membranous obstruction of the inferior vena cava (MOVC)âassociated hepatocellular
carcinoma (HCC) and to evaluate the clinical efficacy of transcatheter arterial chemoembolization (TACE).
Materials and Methods: This retrospective study was approved by an institutional review board, and informed consent was waived. Ninety-eight patients
(mean age, 48.5 years ± 12.9 [standard deviation]) with MOVC were retrospectively evaluated. The diagnosis of Budd-Chiari
syndrome was confirmed with results from Doppler ultrasonography, computed tomography, magnetic resonance imaging, and/or
inferior venacavography. The cumulative incidences of HCC and the patient survival period were calculated by using the Kaplan-Meier
method. Factors associated with the development of HCC were evaluated by using multivariate Cox regression analysis.
Results: Among 98 patients with MOVC, liver nodules were detected in 37 patients (38%), 23 of whom had HCC associated with MOVC and
14 of whom had benign nodules. The cumulative incidence of HCC at 1, 5, and 10 years was 7.3%, 13.5%, and 31.8%, respectively.
Female sex was the only significant factor associated with the development of HCC (odds ratio, 6.02; P <.001). HCC was of the single nodular type and of peripheral location. Among 23 patients with HCC, 20 patients were treated
with only TACE and three with liver transplantation after TACE. After TACE, 14 (61%) of the study patients had a complete
response, and survival rates at 1, 2, 3, 4, and 5 years were 90%, 85%, 61%, 61%, and 46%, respectively.
Conclusion: The incidence of HCC in patients with MOVC was similar to that found in other studies. TACE resulted in an effective tumor
response for HCC and seemed to be effective in prolonging patient survival. Female sex was the only significant factor associated
with the development of HCC. A single nodular tumor with a peripheral location appears to have a higher probability of HCC.
© RSNA, 2010</description><identifier>ISSN: 0033-8419</identifier><identifier>EISSN: 1527-1315</identifier><identifier>DOI: 10.1148/radiol.09090738</identifier><language>eng</language><publisher>Radiological Society of North America</publisher><ispartof>Radiology, 2010-02, Vol.254 (2), p.617</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Dong Gwon II</creatorcontrib><creatorcontrib>Gi-Young Ko</creatorcontrib><creatorcontrib>Hyun-Ki Yoon</creatorcontrib><creatorcontrib>Kyu-Bo Sung</creatorcontrib><creatorcontrib>Jin Hyoung Kim</creatorcontrib><creatorcontrib>Seung Soo Lee</creatorcontrib><creatorcontrib>Jae Myeong Lee</creatorcontrib><creatorcontrib>Joon-Young Ohm</creatorcontrib><creatorcontrib>Ji Hoon Shin</creatorcontrib><creatorcontrib>Ho-Young Song</creatorcontrib><title>Hepatocellular Carcinoma Associated with Membranous Obstruction of the Inferior Vena Cava: Incidence, Characteristics, and Risk Factors and Clinical Efficacy of TACE1</title><title>Radiology</title><description>Purpose: To analyze the characteristics associated with membranous obstruction of the inferior vena cava (MOVC)âassociated hepatocellular
carcinoma (HCC) and to evaluate the clinical efficacy of transcatheter arterial chemoembolization (TACE).
Materials and Methods: This retrospective study was approved by an institutional review board, and informed consent was waived. Ninety-eight patients
(mean age, 48.5 years ± 12.9 [standard deviation]) with MOVC were retrospectively evaluated. The diagnosis of Budd-Chiari
syndrome was confirmed with results from Doppler ultrasonography, computed tomography, magnetic resonance imaging, and/or
inferior venacavography. The cumulative incidences of HCC and the patient survival period were calculated by using the Kaplan-Meier
method. Factors associated with the development of HCC were evaluated by using multivariate Cox regression analysis.
Results: Among 98 patients with MOVC, liver nodules were detected in 37 patients (38%), 23 of whom had HCC associated with MOVC and
14 of whom had benign nodules. The cumulative incidence of HCC at 1, 5, and 10 years was 7.3%, 13.5%, and 31.8%, respectively.
Female sex was the only significant factor associated with the development of HCC (odds ratio, 6.02; P <.001). HCC was of the single nodular type and of peripheral location. Among 23 patients with HCC, 20 patients were treated
with only TACE and three with liver transplantation after TACE. After TACE, 14 (61%) of the study patients had a complete
response, and survival rates at 1, 2, 3, 4, and 5 years were 90%, 85%, 61%, 61%, and 46%, respectively.
Conclusion: The incidence of HCC in patients with MOVC was similar to that found in other studies. TACE resulted in an effective tumor
response for HCC and seemed to be effective in prolonging patient survival. Female sex was the only significant factor associated
with the development of HCC. A single nodular tumor with a peripheral location appears to have a higher probability of HCC.
© RSNA, 2010</description><issn>0033-8419</issn><issn>1527-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqVkMtKw0AYhQdRMF7Wbv8HSGomF5O6KyGlLkSQ4jb8mUyaXyczZWZi6Qv5nI2XF5CzOPDxcRaHsTseLzjPynuLHRm1iJdzirQ8YwHPkyLiKc_PWRDHaRqVGV9esivn3uOYZ3lZBOxrI_fojZBKTQotVGgFaTMirJwzgtDLDg7kB3iWY2tRm8nBS-u8nYQno8H04AcJT7qXloyFN6lxXvnEx5kJ6qQWMoRqQIvCz4rzJFwIqDt4JfcB6xkb635ApUiTQAV1388tjt_r21VV8xt20aNy8vavr1m4rrfVJhpoNxzIysaNqNR-atPm9wizOyZ51iTNAy_Sf-onDUVsbA</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Dong Gwon II</creator><creator>Gi-Young Ko</creator><creator>Hyun-Ki Yoon</creator><creator>Kyu-Bo Sung</creator><creator>Jin Hyoung Kim</creator><creator>Seung Soo Lee</creator><creator>Jae Myeong Lee</creator><creator>Joon-Young Ohm</creator><creator>Ji Hoon Shin</creator><creator>Ho-Young Song</creator><general>Radiological Society of North America</general><scope/></search><sort><creationdate>20100201</creationdate><title>Hepatocellular Carcinoma Associated with Membranous Obstruction of the Inferior Vena Cava: Incidence, Characteristics, and Risk Factors and Clinical Efficacy of TACE1</title><author>Dong Gwon II ; Gi-Young Ko ; Hyun-Ki Yoon ; Kyu-Bo Sung ; Jin Hyoung Kim ; Seung Soo Lee ; Jae Myeong Lee ; Joon-Young Ohm ; Ji Hoon Shin ; Ho-Young Song</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-highwire_smallpub3_radiology254_2_6173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong Gwon II</creatorcontrib><creatorcontrib>Gi-Young Ko</creatorcontrib><creatorcontrib>Hyun-Ki Yoon</creatorcontrib><creatorcontrib>Kyu-Bo Sung</creatorcontrib><creatorcontrib>Jin Hyoung Kim</creatorcontrib><creatorcontrib>Seung Soo Lee</creatorcontrib><creatorcontrib>Jae Myeong Lee</creatorcontrib><creatorcontrib>Joon-Young Ohm</creatorcontrib><creatorcontrib>Ji Hoon Shin</creatorcontrib><creatorcontrib>Ho-Young Song</creatorcontrib><jtitle>Radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong Gwon II</au><au>Gi-Young Ko</au><au>Hyun-Ki Yoon</au><au>Kyu-Bo Sung</au><au>Jin Hyoung Kim</au><au>Seung Soo Lee</au><au>Jae Myeong Lee</au><au>Joon-Young Ohm</au><au>Ji Hoon Shin</au><au>Ho-Young Song</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatocellular Carcinoma Associated with Membranous Obstruction of the Inferior Vena Cava: Incidence, Characteristics, and Risk Factors and Clinical Efficacy of TACE1</atitle><jtitle>Radiology</jtitle><date>2010-02-01</date><risdate>2010</risdate><volume>254</volume><issue>2</issue><spage>617</spage><pages>617-</pages><issn>0033-8419</issn><eissn>1527-1315</eissn><abstract>Purpose: To analyze the characteristics associated with membranous obstruction of the inferior vena cava (MOVC)âassociated hepatocellular
carcinoma (HCC) and to evaluate the clinical efficacy of transcatheter arterial chemoembolization (TACE).
Materials and Methods: This retrospective study was approved by an institutional review board, and informed consent was waived. Ninety-eight patients
(mean age, 48.5 years ± 12.9 [standard deviation]) with MOVC were retrospectively evaluated. The diagnosis of Budd-Chiari
syndrome was confirmed with results from Doppler ultrasonography, computed tomography, magnetic resonance imaging, and/or
inferior venacavography. The cumulative incidences of HCC and the patient survival period were calculated by using the Kaplan-Meier
method. Factors associated with the development of HCC were evaluated by using multivariate Cox regression analysis.
Results: Among 98 patients with MOVC, liver nodules were detected in 37 patients (38%), 23 of whom had HCC associated with MOVC and
14 of whom had benign nodules. The cumulative incidence of HCC at 1, 5, and 10 years was 7.3%, 13.5%, and 31.8%, respectively.
Female sex was the only significant factor associated with the development of HCC (odds ratio, 6.02; P <.001). HCC was of the single nodular type and of peripheral location. Among 23 patients with HCC, 20 patients were treated
with only TACE and three with liver transplantation after TACE. After TACE, 14 (61%) of the study patients had a complete
response, and survival rates at 1, 2, 3, 4, and 5 years were 90%, 85%, 61%, 61%, and 46%, respectively.
Conclusion: The incidence of HCC in patients with MOVC was similar to that found in other studies. TACE resulted in an effective tumor
response for HCC and seemed to be effective in prolonging patient survival. Female sex was the only significant factor associated
with the development of HCC. A single nodular tumor with a peripheral location appears to have a higher probability of HCC.
© RSNA, 2010</abstract><pub>Radiological Society of North America</pub><doi>10.1148/radiol.09090738</doi></addata></record> |
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| title | Hepatocellular Carcinoma Associated with Membranous Obstruction of the Inferior Vena Cava: Incidence, Characteristics, and Risk Factors and Clinical Efficacy of TACE1 |
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